Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolys...

por Yamamoto, Ryuji, Yoden, Eiji, Tanaka, Noboru, Kinoshita, Masafumi, Imakiire, Atsushi, Hirato, Tohru, Minami, Kohtaro
Publicado 2021

Dose-dependent effects of a brain-penetrating iduronate-2-sulfatase on neurobehavioral impairments in mucopolysaccharidosis II mice

por Morimoto, Hideto, Morioka, Hiroki, Imakiire, Atsushi, Yamamoto, Ryuji, Hirato, Tohru, Sonoda, Hiroyuki, Minami, Kohtaro
Publicado 2022

Pathogenic Roles of Heparan Sulfate and Its Use as a Biomarker in Mucopolysaccharidoses

por Minami, Kohtaro, Morimoto, Hideto, Morioka, Hiroki, Imakiire, Atsushi, Kinoshita, Masafumi, Yamamoto, Ryuji, Hirato, Tohru, Sonoda, Hiroyuki
Publicado 2022

Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice

por Imakiire, Atsushi, Morimoto, Hideto, Suzuki, Hidehiko, Masuda, Tomomi, Yoden, Eiji, Inoue, Asuka, Morioka, Hiroki, Konaka, Takashi, Mori, Ayaka, Shirasaka, Ryoji, Kato, Ryo, Hirato, Tohru, Sonoda, Hiroyuki, Minami, Kohtaro
Publicado 2023

Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice

por Kida, Sachiho, Koshimura, Yuri, Yoden, Eiji, Yoshioka, Aya, Morimoto, Hideto, Imakiire, Atsushi, Tanaka, Noboru, Tanaka, Satowa, Mori, Ayaka, Ito, Jun, Inoue, Asuka, Yamamoto, Ryuji, Minami, Kohtaro, Hirato, Tohru, Takahashi, Kenichi, Sonoda, Hiroyuki
Publicado 2023