Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos

por Imokawa, Genji
Publicado 2019

Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role

por Imokawa, Genji
Publicado 2021

Inhibitors of Intracellular Signaling Pathways that Lead to Stimulated Epidermal Pigmentation: Perspective of Anti-Pigmenting Agents

por Imokawa, Genji, Ishida, Koichi
Publicado 2014

Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging I: Reduced Skin Elasticity, Highly Associated with Enhanced Dermal Elasta...

por Imokawa, Genji, Ishida, Koichi
Publicado 2015

Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role

por Imokawa, Genji, Nakajima, Hiroaki, Ishida, Koichi
Publicado 2015

Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents

por Takeda, Shogo, Shimoda, Hiroshi, Takarada, Toru, Imokawa, Genji
Publicado 2018

β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructe...

por Takeda, Shogo, Terazawa, Shuko, Shimoda, Hiroshi, Imokawa, Genji
Publicado 2021

The UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFκB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Inter...

por Terazawa, Shuko, Mori, Shingo, Nakajima, Hiroaki, Yasuda, Michitaka, Imokawa, Genji
Publicado 2015

The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts

por Nakajima, Hiroaki, Terazawa, Shuko, Niwano, Takao, Yamamoto, Yorihiro, Imokawa, Genji
Publicado 2016

The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signali...

por Terazawa, Shuko, Takada, Mariko, Sato, Yoriko, Nakajima, Hiroaki, Imokawa, Genji
Publicado 2021

A Nano-Emulsion Containing Ceramide-like Lipo-Amino Acid Cholesteryl Derivatives Improves Skin Symptoms in Patients with Atopic Dermatitis by Ameliorating the Water-Holding Functio...

por Takada, Mariko, Ishikawa, Yuko, Numano, Kayoko, Hirano, Shinichi, Imokawa, Genji
Publicado 2022

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

por Igarashi, Tami, Yanagi, Hiroki, Yagi, Masayuki, Ichihashi, Masamitsu, Imokawa, Genji
Publicado 2023

UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Marit...

por Tagashira, Hideki, Miyamoto, Aki, Kitamura, Sei-ichi, Tsubata, Masahito, Yamaguchi, Kazuya, Takagaki, Kinya, Imokawa, Genji
Publicado 2015

Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase

por Teranishi, Yasuhiro, Kuwahara, Hiroshi, Ueda, Masaru, Takemura, Tadashi, Kusumoto, Masanori, Nakamura, Keiji, Sakai, Jun, Kimura, Toru, Furutani, Yasuji, Kawashima, Makoto, Imokawa, Genji, Nogami-Itoh, Mari
Publicado 2020