A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

por Hastings, P. J., Ira, Grzegorz, Lupski, James R.
Publicado 2009

Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

por Chung, Woo-Hyun, Zhu, Zhu, Papusha, Alma, Malkova, Anna, Ira, Grzegorz
Publicado 2010

A novel role of the Dna2 translocase function in DNA break resection

por Miller, Adam S., Daley, James M., Pham, Nhung Tuyet, Niu, Hengyao, Xue, Xiaoyu, Ira, Grzegorz, Sung, Patrick
Publicado 2017

Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks

por Yu, Yang, Pham, Nhung, Xia, Bo, Papusha, Alma, Wang, Guangyu, Yan, Zhenxin, Peng, Guang, Chen, Kaifu, Ira, Grzegorz
Publicado 2018

A Rad51-independent pathway promotes single-strand template repair in gene editing

por Gallagher, Danielle N., Pham, Nhung, Tsai, Annie M., Janto, Nicolas V., Choi, Jihyun, Ira, Grzegorz, Haber, James E.
Publicado 2020

The Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends

por Chen, Xuefeng, Cui, Dandan, Papusha, Alma, Zhang, Xiaotian, Chu, Chia-Dwo, Tang, Jiangwu, Chen, Kaifu, Pan, Xuewen, Ira, Grzegorz
Publicado 2012

Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble

por Shen, Jiangchuan, Zhao, Yiling, Pham, Nhung Tuyet, Li, Yuxi, Zhang, Yixiang, Trinidad, Jonathan, Ira, Grzegorz, Qi, Zhi, Niu, Hengyao
Publicado 2022

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

por Chen, Xuefeng, Niu, Hengyao, Chung, Woo-Hyun, Zhu, Zhu, Papusha, Alma, Shim, Eun Yong, Lee, Sang Eun, Sung, Patrick, Ira, Grzegorz
Publicado 2011

Migrating bubble during break-induced replication drives conservative DNA synthesis

por Saini, Natalie, Ramakrishnan, Sreejith, Elango, Rajula, Ayyar, Sandeep, Zhang, Yu, Deem, Angela, Ira, Grzegorz, Haber, James E., Lobachev, Kirill S., Malkova, Anna
Publicado 2013

Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA

por Lopez, Christopher R., Singh, Shivani, Hambarde, Shashank, Griffin, Wezley C., Gao, Jun, Chib, Shubeena, Yu, Yang, Ira, Grzegorz, Raney, Kevin D., Kim, Nayun
Publicado 2017

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

por Lemaçon, Delphine, Jackson, Jessica, Quinet, Annabel, Brickner, Joshua R., Li, Shan, Yazinski, Stephanie, You, Zhongsheng, Ira, Grzegorz, Zou, Lee, Mosammaparast, Nima, Vindigni, Alessandro
Publicado 2017

Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection

por Chen, Xuefeng, Niu, Hengyao, Yu, Yang, Wang, Jingjing, Zhu, Shuangyi, Zhou, Jianjie, Papusha, Alma, Cui, Dandan, Pan, Xuewen, Kwon, Youngho, Sung, Patrick, Ira, Grzegorz
Publicado 2016

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

por Wilson, Marenda A., Kwon, YoungHo, Xu, Yuanyuan, Chung, Woo-Hyun, Chi, Peter, Niu, Hengyao, Mayle, Ryan, Chen, Xuefeng, Malkova, Anna, Sung, Patrick, Ira, Grzegorz
Publicado 2013

Selective modulation of the functions of a conserved DNA motor by a histone fold complex

por Xue, Xiaoyu, Choi, Koyi, Bonner, Jacob N., Szakal, Barnabas, Chen, Yu-Hung, Papusha, Alma, Saro, Dorina, Niu, Hengyao, Ira, Grzegorz, Branzei, Dana, Sung, Patrick, Zhao, Xiaolan
Publicado 2015

Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

por Elango, Rajula, Sheng, Ziwei, Jackson, Jessica, DeCata, Jenna, Ibrahim, Younis, Pham, Nhung T., Liang, Diana H., Sakofsky, Cynthia J., Vindigni, Alessandro, Lobachev, Kirill S., Ira, Grzegorz, Malkova, Anna
Publicado 2017

Tracking break induced replication reveals its stalling at roadblocks

por Liu, Liping, Yan, Zhenxin, Osia, Beth A, Twarowski, Jerzy, Sun, Luyang, Kramara, Juraj, Lee, Rosemary, Kumar, Sandeep, Elango, Rajula, Li, Hanzeng, Dang, Weiwei, Ira, Grzegorz, Malkova, Anna
Publicado 2021

Predicting human genes susceptible to genomic instability associated with Alu/Alu-mediated rearrangements

por Song, Xiaofei, Beck, Christine R., Du, Renqian, Campbell, Ian M., Coban-Akdemir, Zeynep, Gu, Shen, Breman, Amy M., Stankiewicz, Pawel, Ira, Grzegorz, Shaw, Chad A., Lupski, James R.
Publicado 2018

Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks

por Zheng, Sihao, Li, Dan, Lu, Zhen, Liu, Guangxue, Wang, Meng, Xing, Poyuan, Wang, Min, Dong, Yang, Wang, Xuejie, Li, Jingyao, Zhang, Simin, Peng, Haoyang, Ira, Grzegorz, Li, Guohong, Chen, Xuefeng
Publicado 2018

Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1

por Xue, Xiaoyu, Papusha, Alma, Choi, Koyi, Bonner, Jacob N., Kumar, Sandeep, Niu, Hengyao, Kaur, Hardeep, Zheng, Xiao-Feng, Donnianni, Roberto A., Lu, Lucy, Lichten, Michael, Zhao, Xiaolan, Ira, Grzegorz, Sung, Patrick
Publicado 2016

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

por Klein, Hannah L., Bačinskaja, Giedrė, Che, Jun, Cheblal, Anais, Elango, Rajula, Epshtein, Anastasiya, Fitzgerald, Devon M., Gómez-González, Belén, Khan, Sharik R., Kumar, Sandeep, Leland, Bryan A., Marie, Léa, Mei, Qian, Miné-Hattab, Judith, Piotrowska, Alicja, Polleys, Erica J., Putnam, Christopher D., Radchenko, Elina A., Saada, Anissia Ait, Sakofsky, Cynthia J., Shim, Eun Yong, Stracy, Mathew, Xia, Jun, Yan, Zhenxin, Yin, Yi, Aguilera, Andrés, Argueso, Juan Lucas, Freudenreich, Catherine H., Gasser, Susan M., Gordenin, Dmitry A., Haber, James E., Ira, Grzegorz, Jinks-Robertson, Sue, King, Megan C., Kolodner, Richard D., Kuzminov, Andrei, Lambert, Sarah AE, Lee, Sang Eun, Miller, Kyle M., Mirkin, Sergei M., Petes, Thomas D., Rosenberg, Susan M., Rothstein, Rodney, Symington, Lorraine S., Zawadzki, Pawel, Kim, Nayun, Lisby, Michael, Malkova, Anna
Publicado 2019