Phase I dose-finding study of cabazitaxel administered weekly in patients with advanced solid tumours

por Fumoleau, Pierre, Trigo, Jose Manuel, Isambert, Nicolas, Sémiond, Dorothée, Gupta, Sunil, Campone, Mario
Publicado 2013

Health-related quality of life as an endpoint in oncology phase I trials: a systematic review

por Fiteni, Frédéric, Ray, Isabelle Le, Ousmen, Ahmad, Isambert, Nicolas, Anota, Amélie, Bonnetain, Franck
Publicado 2019

Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study

por Chanteloup, Gaétan, Cordonnier, Marine, Isambert, Nicolas, Bertaut, Aurélie, Marcion, Guillaume, Garrido, Carmen, Gobbo, Jessica
Publicado 2020

Phase Ib/II trial evaluating the safety, tolerability and immunological activity of durvalumab (MEDI4736) (anti-PD-L1) plus tremelimumab (anti-CTLA-4) combined with FOLFOX in patie...

por Fumet, Jean-David, Isambert, Nicolas, Hervieu, Alice, Zanetta, Sylvie, Guion, Jean-Florian, Hennequin, Audrey, Rederstorff, Emilie, Bertaut, Aurélie, Ghiringhelli, Francois
Publicado 2018

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Esophageal Adenocarcinoma: Results from a Phase 1 Cohort

por Tan, Benjamin, Khattak, Adnan, Felip, Enriqueta, Kelly, Karen, Rich, Patricia, Wang, Ding, Helwig, Christoph, Dussault, Isabelle, Ojalvo, Laureen S., Isambert, Nicolas
Publicado 2021

Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors

por Isambert, Nicolas, Fumoleau, Pierre, Paul, Catherine, Ferrand, Christophe, Zanetta, Sylvie, Bauer, Jacques, Ragot, Kevin, Lizard, Gérard, Jeannin, Jean-François, Bardou, Marc
Publicado 2013

Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment

por Martin, Amandine, Seignez, Cédric, Racoeur, Cindy, Isambert, Nicolas, Mabrouk, Nesrine, Scagliarini, Alessandra, Reveneau, Sylvie, Arnould, Laurent, Bettaieb, Ali, Jeannin, Jean-François, Paul, Catherine
Publicado 2018

Phase I trial of afatinib and 3-weekly trastuzumab with optimal anti-diarrheal management in patients with HER2-positive metastatic cancer

por Martin, Nicolas, Isambert, Nicolas, Gomez-Roca, Carlos, Goeldner, Rainer-Georg, Zanetta, Sylvie, Sadrolhefazi, Behbood, de Mont-Serrat, Hélène, Campone, Mario, Delord, Jean-Pierre
Publicado 2018

Efficacy of trabectedin in metastatic solitary fibrous tumor

por Chaigneau, Loïc, Kalbacher, Elsa, Thiery-Vuillemin, Antoine, Fagnoni-Legat, Christine, Isambert, Nicolas, Aherfi, Lionel, Pauchot, Julien, Delroeux, Delphine, Servagi-Vernat, Stephanie, Mansi, Laura, Pivot, Xavier
Publicado 2011

Fluorouracil and bevacizumab plus anakinra for patients with metastatic colorectal cancer refractory to standard therapies (IRAFU): a single-arm phase 2 study

por Isambert, Nicolas, Hervieu, Alice, Rébé, Cedric, Hennequin, Audrey, Borg, Christophe, Zanetta, Sylvie, Chevriaux, Angélique, Richard, Corentin, Derangère, Valentin, Limagne, Emeric, Blanc, Julie, Bertaut, Aurélie, Ghiringhelli, François
Publicado 2018

Identification of HMGA2 as a predictive biomarker of response to bintrafusp alfa in a phase 1 trial in patients with advanced triple-negative breast cancer

por Spira, Alexander, Awada, Ahmad, Isambert, Nicolas, Lorente, David, Penel, Nicolas, Zhang, Yue, Ojalvo, Laureen S., Hicking, Christine, Rolfe, P. Alexander, Ihling, Christian, Dussault, Isabelle, Locke, George, Borel, Christian
Publicado 2022

A Phase I, Dose-Escalation Trial of Pazopanib in Combination with Cisplatin in Patients with Advanced Solid Tumors: A UNICANCER Study

por Diéras, Véronique, Bachelot, Thomas, Campone, Mario, Isambert, Nicolas, Joly, Florence, Le Tourneau, Christophe, Cassier, Philippe, Bompas, Emmanuelle, Fumoleau, Pierre, Noal, Sabine, Orsini, Christine, Jimenez, Marta, Imbs, Diane Charlotte, Chatelut, Etienne
Publicado 2016

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort

por Cho, Byoung Chul, Daste, Amaury, Ravaud, Alain, Salas, Sébastien, Isambert, Nicolas, McClay, Edward, Awada, Ahmad, Borel, Christian, Ojalvo, Laureen S, Helwig, Christoph, Rolfe, P Alexander, Gulley, James L, Penel, Nicolas
Publicado 2020

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Non-Small Cell Lung Cancer Resistant or Refractory to Immune Checkpoint Inhibitors

por Barlesi, Fabrice, Isambert, Nicolas, Felip, Enriqueta, Cho, Byoung Chul, Lee, Dae Ho, Peguero, Julio, Jerusalem, Guy, Penel, Nicolas, Saada-Bouzid, Esma, Garrido, Pilar, Helwig, Christoph, Locke, George, Ojalvo, Laureen S, Gulley, James L
Publicado 2022

Circulating tumor DNA predicts efficacy of a dual AKT/p70S6K inhibitor (LY2780301) plus paclitaxel in metastatic breast cancer: plasma analysis of the TAKTIC phase IB/II study

por Sabatier, Renaud, Vicier, Cécile, Garnier, Séverine, Guille, Arnaud, Carbuccia, Nadine, Isambert, Nicolas, Dalenc, Florence, Robert, Marie, Levy, Christelle, Pakradouni, Jihane, Adelaïde, José, Chaffanet, Max, Sfumato, Patrick, Mamessier, Emilie, Bertucci, François, Goncalves, Anthony
Publicado 2022

Primary localized rectal/pararectal gastrointestinal stromal tumors: results of surgical and multimodal therapy from the French Sarcoma group

por Huynh, Thanh-Khoa, Meeus, Pierre, Cassier, Philippe, Bouché, Olivier, Lardière-Deguelte, Sophie, Adenis, Antoine, André, Thierry, Mancini, Julien, Collard, Olivier, Montemurro, Michael, Bompas, Emmanuelle, Rios, Maria, Isambert, Nicolas, Cupissol, Didier, Blay, Jean-Yves, Duffaud, Florence
Publicado 2014

ONCOS-102 plus pemetrexed and platinum chemotherapy in malignant pleural mesothelioma: a randomized phase 2 study investigating clinical outcomes and the tumor microenvironment

por Ponce, Santiago, Cedrés, Susana, Ricordel, Charles, Isambert, Nicolas, Viteri, Santiago, Herrera-Juarez, Mercedes, Martinez-Marti, Alex, Navarro, Alejandro, Lederlin, Mathieu, Serres, Xavier, Zugazagoitia, Jon, Vetrhus, Sylvia, Jaderberg, Magnus, Hansen, Thomas Birkballe, Levitsky, Victor, Paz-Ares, Luis
Publicado 2023

First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers

por Angevin, Eric, Isambert, Nicolas, Trillet-Lenoir, Véronique, You, Benoit, Alexandre, Jérôme, Zalcman, Gérard, Vielh, Philippe, Farace, Françoise, Valleix, Fanny, Podoll, Thomas, Kuramochi, Yu, Miyashita, Itaru, Hosono, Osamu, Dang, Nam H, Ohnuma, Kei, Yamada, Taketo, Kaneko, Yutaro, Morimoto, Chikao
Publicado 2017

Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use prog...

por Blay, Jean-Yves, Italiano, Antoine, Ray-Coquard, Isabelle, Le Cesne, Axel, Duffaud, Florence, Rios, Maria, Collard, Olivier, Bertucci, François, Bompas, Emmanuelle, Isambert, Nicolas, Chaigneau, Loic, Cassier, Philippe, Bui, Binh, Decanter, Gauthier, Derbel, Olfa, Coindre, Jean-Michel, Zintl, Patrick, Badri, Nadia, Penel, Nicolas
Publicado 2013

EPIGIST: An observational real-life study on patients with metastatic gastrointestinal stromal tumors receiving imatinib

por Bouché, Olivier, Cesne, Axel Le, Rios, Maria, Chaigneau, Loic, Italiano, Antoine, Duffaud, Florence, Lecomte, Thierry, Arsène, Dominique, Manfredi, Sylvain, Aparicio, Thomas, Remy, Stéphane, Isambert, Nicolas, Collard, Olivier, Priou, Frank, Bertucci, François, Sambuc, Roland, Bisot-Locard, Ségolene, Bourges, Olivier, Chabaud, Sylvie, Blay, Jean-Yves
Publicado 2018