Pharmacokinetics of Biopharmaceuticals: Their Critical Role in Molecular Design

por Ogihara, Takuo, Mizoi, Kenta, Ishii-Watabe, Akiko
Publicado 2023

Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex

por Tada, Minoru, Aoyama, Michihiko, Ishii-Watabe, Akiko
Publicado 2023

Development and characterization of an anti-rituximab monoclonal antibody panel

por Tada, Minoru, Suzuki, Takuo, Ishii-Watabe, Akiko
Publicado 2018

Establishment of a highly precise multi-attribute method for the characterization and quality control of therapeutic monoclonal antibodies

por Tajiri-Tsukada, Michiko, Hashii, Noritaka, Ishii-Watabe, Akiko
Publicado 2020

Development of a Cell-Based Assay Measuring the Activation of FcγRIIa for the Characterization of Therapeutic Monoclonal Antibodies

por Tada, Minoru, Ishii-Watabe, Akiko, Suzuki, Takuo, Kawasaki, Nana
Publicado 2014

The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein

por Suzuki, Takuo, Hashii, Noritaka, Tada, Minoru, Ishii-Watabe, Akiko
Publicado 2021

Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates

por Aoyama, Michihiko, Tada, Minoru, Yokoo, Hidetomo, Demizu, Yosuke, Ishii-Watabe, Akiko
Publicado 2021

Structural insight and stability of TNFR-Fc fusion protein (Etanercept) produced by using transgenic silkworms

por Kiyoshi, Masato, Tatematsu, Ken-Ichiro, Tada, Minoru, Sezutsu, Hideki, Shibata, Hiroko, Ishii-Watabe, Akiko
Publicado 2020

Evaluation of the analytical performance of anti-SARS-CoV-2 antibody test kits distributed or developed in Japan

por Shibata, Hiroko, Nishimura, Kazuko, Maeda, Takuya, Honma, Masamitsu, Goda, Yukihiro, Ishii-Watabe, Akiko, Saito, Yoshiro
Publicado 2022

Biophysical Characterization of the Contribution of the Fab Region to the IgG-FcγRIIIa Interaction

por Kosuge, Hirofumi, Nagatoishi, Satoru, Kiyoshi, Masato, Ishii-Watabe, Akiko, Terao, Yosuke, Ide, Teruhiko, Tsumoto, Kouhei
Publicado 2022

Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori)

por Tada, Minoru, Tatematsu, Ken-Ichiro, Ishii-Watabe, Akiko, Harazono, Akira, Takakura, Daisuke, Hashii, Noritaka, Sezutsu, Hideki, Kawasaki, Nana
Publicado 2015

Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

por Aoyama, Michihiko, Hashii, Noritaka, Tsukimura, Wataru, Osumi, Kenji, Harazono, Akira, Tada, Minoru, Kiyoshi, Masato, Matsuda, Akio, Ishii-Watabe, Akiko
Publicado 2019

Highly sensitive HPLC analysis and biophysical characterization of N‐glycans of IgG‐Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand

por Kosuge, Hirofumi, Nagatoishi, Satoru, Kiyoshi, Masato, Ishii‐Watabe, Akiko, Tanaka, Toru, Terao, Yosuke, Oe, Seigo, Ide, Teruhiko, Tsumoto, Kouhei
Publicado 2020

Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in...

por Krayukhina, Elena, Noda, Masanori, Ishii, Kentaro, Maruno, Takahiro, Wakabayashi, Hirotsugu, Tada, Minoru, Suzuki, Takuo, Ishii-Watabe, Akiko, Kato, Masahiko, Uchiyama, Susumu
Publicado 2017

Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics

por Kiyoshi, Masato, Nakakido, Makoto, Rafique, Abdur, Tada, Minoru, Aoyama, Michihiko, Terao, Yosuke, Nagatoishi, Satoru, Shibata, Hiroko, Ide, Teruhiko, Tsumoto, Kouhei, Ito, Yuji, Ishii-Watabe, Akiko
Publicado 2023

Efficacy and safety evaluation of claudin‐4‐targeted antitumor therapy using a human and mouse cross‐reactive monoclonal antibody

por Hashimoto, Yosuke, Kawahigashi, Yumi, Hata, Tomoyuki, Li, Xiangru, Watari, Akihiro, Tada, Minoru, Ishii‐Watabe, Akiko, Okada, Yoshiaki, Doi, Takefumi, Fukasawa, Masayoshi, Kuniyasu, Hiroki, Yagi, Kiyohito, Kondoh, Masuo
Publicado 2016

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD

por George, Ginto, Ninagawa, Satoshi, Yagi, Hirokazu, Furukawa, Jun-ichi, Hashii, Noritaka, Ishii-Watabe, Akiko, Deng, Ying, Matsushita, Kazutoshi, Ishikawa, Tokiro, Mamahit, Yugoviandi P, Maki, Yuta, Kajihara, Yasuhiro, Kato, Koichi, Okada, Tetsuya, Mori, Kazutoshi
Publicado 2021

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

por Kiyoshi, Masato, Caaveiro, Jose M. M., Tada, Minoru, Tamura, Hiroko, Tanaka, Toru, Terao, Yosuke, Morante, Koldo, Harazono, Akira, Hashii, Noritaka, Shibata, Hiroko, Kuroda, Daisuke, Nagatoishi, Satoru, Oe, Seigo, Ide, Teruhiko, Tsumoto, Kouhei, Ishii-Watabe, Akiko
Publicado 2018

Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees

por Inoue, Takeshi, Shinnakasu, Ryo, Kawai, Chie, Yamamoto, Hiromi, Sakakibara, Shuhei, Ono, Chikako, Itoh, Yumi, Terooatea, Tommy, Yamashita, Kazuo, Okamoto, Toru, Hashii, Noritaka, Ishii-Watabe, Akiko, Butler, Noah S., Matsuura, Yoshiharu, Matsumoto, Hisatake, Otsuka, Shinya, Hiraoka, Kei, Teshima, Takanori, Murakami, Masaaki, Kurosaki, Tomohiro
Publicado 2022

Approaches to Quality Risk Management When Using Single-Use Systems in the Manufacture of Biologics

por Ishii-Watabe, Akiko, Hirose, Akihiko, Katori, Noriko, Hashii, Norikata, Arai, Susumu, Awatsu, Hirotoshi, Eiza, Akira, Hara, Yoshiaki, Hattori, Hideshi, Inoue, Tomomi, Isono, Tetsuya, Iwakura, Masahiro, Kajihara, Daisuke, Kasahara, Nobuo, Matsuda, Hiroyuki, Murakami, Sei, Nakagawa, Taishiro, Okumura, Takehiro, Omasa, Takeshi, Takuma, Shinya, Terashima, Iyo, Tsukahara, Masayoshi, Tsutsui, Maiko, Yano, Takahiro, Kawasaki, Nana
Publicado 2015