Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson’s Disease

por Valentine, Matthew N. Z., Hashimoto, Kosuke, Fukuhara, Takeshi, Saiki, Shinji, Ishikawa, Kei-ichi, Hattori, Nobutaka, Carninci, Piero
Publicado 2019

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

por Yokota, Mutsumi, Kakuta, Soichiro, Shiga, Takahiro, Ishikawa, Kei-ichi, Okano, Hideyuki, Hattori, Nobutaka, Akamatsu, Wado, Koike, Masato
Publicado 2021

A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson’s disease

por Nakamura, Ryota, Nonaka, Risa, Oyama, Genko, Jo, Takayuki, Kamo, Hikaru, Nuermaimaiti, Maierdanjiang, Akamatsu, Wado, Ishikawa, Kei-ichi, Hattori, Nobutaka
Publicado 2023

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

por Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Sano, Osamu, Iwata, Hidehisa, Ishikawa, Kei-ichi, Okano, Hideyuki, Akamatsu, Wado, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2020

Reduced ER-mitochondrial contact sites and mitochondrial Ca(2+) flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

por Yokota, Mutsumi, Yoshino, Yutaro, Hosoi, Mitsuko, Hashimoto, Ryota, Kakuta, Soichiro, Shiga, Takahiro, Ishikawa, Kei-Ichi, Okano, Hideyuki, Hattori, Nobutaka, Akamatsu, Wado, Koike, Masato
Publicado 2023

p150(glued)-Associated Disorders Are Caused by Activation of Intrinsic Apoptotic Pathway

por Ishikawa, Kei-Ichi, Saiki, Shinji, Furuya, Norihiko, Yamada, Daisuke, Imamichi, Yoko, Li, Yuanzhe, Kawajiri, Sumihiro, Sasaki, Hironori, Koike, Masato, Tsuboi, Yoshio, Hattori, Nobutaka
Publicado 2014

Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy

por Mori, Akio, Ishikawa, Kei-Ichi, Saiki, Shinji, Hatano, Taku, Oji, Yutaka, Okuzumi, Ayami, Fujimaki, Motoki, Koinuma, Takahiro, Ueno, Shin-Ichi, Imamichi, Yoko, Hattori, Nobutaka
Publicado 2019

Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson’s Disease

por Ueno, Shin-Ichi, Saiki, Shinji, Fujimaki, Motoki, Takeshige-Amano, Haruka, Hatano, Taku, Oyama, Genko, Ishikawa, Kei-Ichi, Yamaguchi, Akihiro, Nojiri, Shuko, Akamatsu, Wado, Hattori, Nobutaka
Publicado 2018

Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2

por Torii, Satoru, Arakawa, Satoko, Sato, Shigeto, Ishikawa, Kei‐ichi, Taniguchi, Daisuke, Sakurai, Hajime Tajima, Honda, Shinya, Hiraoka, Yuuichi, Ono, Masaya, Akamatsu, Wado, Hattori, Nobutaka, Shimizu, Shigeomi
Publicado 2023

Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease

por Yamaguchi, Akihiro, Ishikawa, Kei-ichi, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Saiki, Shinji, Hatano, Taku, Mori, Akio, Oji, Yutaka, Okuzumi, Ayami, Li, Yuanzhe, Funayama, Manabu, Imai, Yuzuru, Hattori, Nobutaka, Akamatsu, Wado
Publicado 2020

Metabolomics‐based identification of metabolic alterations in PARK2

por Okuzumi, Ayami, Hatano, Taku, Ueno, Shin‐Ichi, Ogawa, Takashi, Saiki, Shinji, Mori, Akio, Koinuma, Takahiro, Oji, Yutaka, Ishikawa, Kei‐Ichi, Fujimaki, Motoki, Sato, Shigeto, Ramamoorthy, Sivapriya, Mohney, Robert P., Hattori, Nobutaka
Publicado 2019

Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease

por Saiki, Shinji, Hatano, Taku, Fujimaki, Motoki, Ishikawa, Kei-Ichi, Mori, Akio, Oji, Yutaka, Okuzumi, Ayami, Fukuhara, Takeshi, Koinuma, Takahiro, Imamichi, Yoko, Nagumo, Miho, Furuya, Norihiko, Nojiri, Shuko, Amo, Taku, Yamashiro, Kazuo, Hattori, Nobutaka
Publicado 2017

Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations

por Kano, Masayoshi, Takanashi, Masashi, Oyama, Genko, Yoritaka, Asako, Hatano, Taku, Shiba-Fukushima, Kahori, Nagai, Makiko, Nishiyama, Kazutoshi, Hasegawa, Kazuko, Inoshita, Tsuyoshi, Ishikawa, Kei-ichi, Akamatsu, Wado, Imai, Yuzuru, Bolognin, Silvia, Schwamborn, Jens Christian, Hattori, Nobutaka
Publicado 2020

Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease

por Fujimaki, Motoki, Saiki, Shinji, Li, Yuanzhe, Kaga, Naoko, Taka, Hikari, Hatano, Taku, Ishikawa, Kei-Ichi, Oji, Yutaka, Mori, Akio, Okuzumi, Ayami, Koinuma, Takahiro, Ueno, Shin-Ichi, Imamichi, Yoko, Ueno, Takashi, Miura, Yoshiki, Funayama, Manabu, Hattori, Nobutaka
Publicado 2018

Shared Metabolic Profile of Caffeine in Parkinsonian Disorders

por Takeshige‐Amano, Haruka, Saiki, Shinji, Fujimaki, Motoki, Ueno, Shin‐Ichi, Li, Yuanzhe, Hatano, Taku, Ishikawa, Kei‐Ichi, Oji, Yutaka, Mori, Akio, Okuzumi, Ayami, Tsunemi, Taiji, Daida, Kensuke, Ishiguro, Yuta, Imamichi, Yoko, Nanmo, Hisayoshi, Nojiri, Shuko, Funayama, Manabu, Hattori, Nobutaka
Publicado 2020