Identifying Small Molecule Compounds that Have Synergistic Effects With Cisplatin and Other Platinum Drugs Using High Throughput Matrix Screening

por Al-Zubi, Layla, Cheff, Dorian M., Itkin, Zina, Guo, Hui, Shen, Min, Hall, Matthew D.
Publicado 2022

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

por Hanson, Quinlin M., Wilson, Kelli M., Shen, Min, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Hall, Matthew D.
Publicado 2020

Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay

por Hanson, Quinlin M., Wilson, Kelli M., Shen, Min, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Hall, Matthew D.
Publicado 2020

Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries

por Ronzetti, Michael H., Baljinnyam, Bolormaa, Itkin, Zina, Jain, Sankalp, Rai, Ganesha, Zakharov, Alexey V., Pal, Utpal, Simeonov, Anton
Publicado 2022

Deep learning identifies synergistic drug combinations for treating COVID-19

por Jin, Wengong, Stokes, Jonathan M., Eastman, Richard T., Itkin, Zina, Zakharov, Alexey V., Collins, James J., Jaakkola, Tommi S., Barzilay, Regina
Publicado 2021

Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein

por Hu, Xin, Chen, Catherine Z., Xu, Miao, Hu, Zongyi, Guo, Hui, Itkin, Zina, Shinn, Paul, Ivin, Parker, Leek, Madeleine, Liang, T. Jake, Shen, Min, Zheng, Wei, Hall, Matthew D.
Publicado 2021

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

por Bobrowski, Tesia, Chen, Lu, Eastman, Richard T., Itkin, Zina, Shinn, Paul, Chen, Catherine, Guo, Hui, Zheng, Wei, Michael, Sam, Simeonov, Anton, Hall, Matthew D., Zakharov, Alexey V., Muratov, Eugene N.
Publicado 2020

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

por Bobrowski, Tesia, Chen, Lu, Eastman, Richard T., Itkin, Zina, Shinn, Paul, Chen, Catherine Z., Guo, Hui, Zheng, Wei, Michael, Sam, Simeonov, Anton, Hall, Matthew D., Zakharov, Alexey V., Muratov, Eugene N.
Publicado 2021

mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer

por Kumari, Anju, Gesumaria, Lisa, Liu, Yan-Jin, Hughitt, V. Keith, Zhang, Xiaohu, Ceribelli, Michele, Wilson, Kelli M., Klumpp-Thomas, Carleen, Chen, Lu, McKnight, Crystal, Itkin, Zina, Thomas, Craig J., Mock, Beverly A., Schrump, David S., Chen, Haobin
Publicado 2023

ATRT-11. DEVELOPMENT OF NOVEL PRECLINICAL MODELS AND THERAPEUTIC STRATEGIES FOR ETMR

por Cocito, Carolina, Arias-Stella, Esteban Uceda, Zhang, Xiaohu, McKnight, Crystal, Itkin, Zina, Klumpp-Thomas, Carleen, Cruzeiro, Gustavo Alencastro Veiga, Chi, Susan N, Pisapia, David J, Filbin, Mariella G, Dahmane, Nadia, Thomas, Craig J, Greenfield, Jeffrey P
Publicado 2023

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

por Xu, Miao, Pradhan, Manisha, Gorshkov, Kirill, Petersen, Jennifer D., Shen, Min, Guo, Hui, Zhu, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Itkin, Misha, Itkin, Zina, Straus, Marco R., Zimmerberg, Joshua, Zheng, Wei, Whittaker, Gary R., Chen, Catherine Z.
Publicado 2021

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

por Xu, Miao, Pradhan, Manisha, Gorshkov, Kirill, Petersen, Jennifer D., Shen, Min, Guo, Hui, Zhu, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Itkin, Misha, Itkin, Zina, Straus, Marco R., Zimmerberg, Joshua, Zheng, Wei, Whittaker, Gary R., Chen, Catherine Z.
Publicado 2022

A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

por Shrimp, Jonathan H., Janiszewski, John, Chen, Catherine Z., Xu, Miao, Wilson, Kelli M., Kales, Stephen C., Sanderson, Philip E., Shinn, Paul, Itkin, Zina, Guo, Hui, Shen, Min, Klumpp-Thomas, Carleen, Michael, Samuel G., Zheng, Wei, Simeonov, Anton, Hall, Matthew D.
Publicado 2022

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

por Gorshkov, Kirill, Chen, Catherine Z., Bostwick, Robert, Rasmussen, Lynn, Xu, Miao, Pradhan, Manisha, Tran, Bruce Nguyen, Zhu, Wei, Shamim, Khalida, Huang, Wenwei, Hu, Xin, Shen, Min, Klumpp-Thomas, Carleen, Itkin, Zina, Shinn, Paul, Simeonov, Anton, Michael, Sam, Hall, Matthew D., Lo, Donald C., Zheng, Wei
Publicado 2020

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

por Chen, Catherine Z., Shinn, Paul, Itkin, Zina, Eastman, Richard T., Bostwick, Robert, Rasmussen, Lynn, Huang, Ruili, Shen, Min, Hu, Xin, Wilson, Kelli M., Brooks, Brianna, Guo, Hui, Zhao, Tongan, Klump-Thomas, Carleen, Simeonov, Anton, Michael, Samuel G., Lo, Donald C., Hall, Matthew D., Zheng, Wei
Publicado 2020

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

por Chen, Catherine Z., Shinn, Paul, Itkin, Zina, Eastman, Richard T., Bostwick, Robert, Rasmussen, Lynn, Huang, Ruili, Shen, Min, Hu, Xin, Wilson, Kelli M., Brooks, Brianna M., Guo, Hui, Zhao, Tongan, Klump-Thomas, Carleen, Simeonov, Anton, Michael, Samuel G., Lo, Donald C., Hall, Matthew D., Zheng, Wei
Publicado 2021

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

por Shamim, Khalida, Xu, Miao, Hu, Xin, Lee, Emily M, Lu, Xiao, Huang, Ruili, Shah, Pranav, Xu, Xin, Chen, Catherine Z., Shen, Min, Guo, Hui, Chen, Lu, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Klumpp-Thomas, Carleen, Michael, Sam, Simeonov, Anton, Lo, Donald C., Ming, Guo-li, Song, Hongjun, Tang, Hengli, Zheng, Wei, Huang, Wenwei
Publicado 2021

Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

por Sun, Yilun, Baechler, Simone A., Zhang, Xiaohu, Kumar, Suresh, Factor, Valentina M., Arakawa, Yasuhiro, Chau, Cindy H., Okamoto, Kanako, Parikh, Anup, Walker, Bob, Su, Yijun P., Chen, Jiji, Ting, Tabitha, Huang, Shar-yin N., Beck, Erin, Itkin, Zina, McKnight, Crystal, Xie, Changqing, Roper, Nitin, Nijhawan, Deepak, Figg, William Douglas, Meltzer, Paul S., Yang, James C., Thomas, Craig J., Pommier, Yves
Publicado 2023

Preclinical Evaluation of the FGFR-Family Inhibitor Futibatinib for Pediatric Rhabdomyosarcoma

por Wu, Jerry T., Cheuk, Adam, Isanogle, Kristine, Robinson, Christina, Zhang, Xiaohu, Ceribelli, Michele, Beck, Erin, Shinn, Paul, Klumpp-Thomas, Carleen, Wilson, Kelli M., McKnight, Crystal, Itkin, Zina, Sotome, Hiroshi, Hirai, Hiroshi, Calleja, Elizabeth, Wacheck, Volker, Gouker, Brad, Peer, Cody J., Corvalan, Natalia, Milewski, David, Kim, Yong Y., Figg, William D., Edmondson, Elijah F., Thomas, Craig J., Difilippantonio, Simone, Wei, Jun S., Khan, Javed
Publicado 2023

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

por Gorshkov, Kirill, Chen, Catherine Z., Bostwick, Robert, Rasmussen, Lynn, Tran, Bruce Nguyen, Cheng, Yu-Shan, Xu, Miao, Pradhan, Manisha, Henderson, Mark, Zhu, Wei, Oh, Eunkeu, Susumu, Kimihiro, Wolak, Mason, Shamim, Khalida, Huang, Wenwei, Hu, Xin, Shen, Min, Klumpp-Thomas, Carleen, Itkin, Zina, Shinn, Paul, Carlos de la Torre, Juan, Simeonov, Anton, Michael, Sam G., Hall, Matthew D., Lo, Donald C., Zheng, Wei
Publicado 2020