TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection

por Iwata-Yoshikawa, Naoko, Okamura, Tadashi, Shimizu, Yukiko, Hasegawa, Hideki, Takeda, Makoto, Nagata, Noriyo
Publicado 2019

The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model

por Kataoka, Chikako, Suzuki, Tadaki, Kotani, Osamu, Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Ami, Yasushi, Wakita, Takaji, Nishimura, Yorihiro, Shimizu, Hiroyuki
Publicado 2015

High-throughput isolation of SARS-CoV-2 nucleocapsid antibodies for improved antigen detection

por Fujisawa, Mizuki, Adachi, Yu, Onodera, Taishi, Shiwa-Sudo, Nozomi, Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Suzuki, Tadaki, Takeoka, Shinji, Takahashi, Yoshimasa
Publicado 2023

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

por Tseng, Chien-Te, Sbrana, Elena, Iwata-Yoshikawa, Naoko, Newman, Patrick C., Garron, Tania, Atmar, Robert L., Peters, Clarence J., Couch, Robert B.
Publicado 2012

Correction: Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

por Tseng, Chien-Te, Sbrana, Elena, Iwata-Yoshikawa, Naoko, Newman, Patrick C., Garron, Tania, Atmar, Robert L., Peters, Clarence J., Couch, Robert B.
Publicado 2012

Immunotherapeutic Efficacy of IgY Antibodies Targeting the Full-Length Spike Protein in an Animal Model of Middle East Respiratory Syndrome Coronavirus Infection

por El-Kafrawy, Sherif A., Abbas, Aymn T., Sohrab, Sayed S., Tabll, Ashraf A., Hassan, Ahmed M., Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Azhar, Esam I.
Publicado 2021

Middle East Respiratory Syndrome Coronavirus in Dromedaries in Ethiopia Is Antigenically Different From the Middle East Isolate EMC

por Shirato, Kazuya, Melaku, Simenew Keskes, Kawachi, Kengo, Nao, Naganori, Iwata-Yoshikawa, Naoko, Kawase, Miyuki, Kamitani, Wataru, Matsuyama, Shutoku, Tessema, Tesfaye Sisay, Sentsui, Hiroshi
Publicado 2019

Anti-S1 MERS-COV IgY Specific Antibodies Decreases Lung Inflammation and Viral Antigen Positive Cells in the Human Transgenic Mouse Model

por Abbas, Aymn T., El-Kafrawy, Sherif A., Sohrab, Sayed Sartaj, Tabll, Ashraf A., Hassan, Ahmed M., Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Azhar, Esam I.
Publicado 2020

A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection

por Iwata-Yoshikawa, Naoko, Shiwa, Nozomi, Sekizuka, Tsuyoshi, Sano, Kaori, Ainai, Akira, Hemmi, Takuya, Kataoka, Michiyo, Kuroda, Makoto, Hasegawa, Hideki, Suzuki, Tadaki, Nagata, Noriyo
Publicado 2022

Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models

por Kotani, Osamu, Naeem, Asif, Suzuki, Tadaki, Iwata-Yoshikawa, Naoko, Sato, Yuko, Nakajima, Noriko, Hosomi, Takushi, Tsukagoshi, Hiroyuki, Kozawa, Kunihisa, Hasegawa, Hideki, Taguchi, Fumihiro, Shimizu, Hiroyuki, Nagata, Noriyo
Publicado 2016

Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus

por Iwata-Yoshikawa, Naoko, Okamura, Tadashi, Shimizu, Yukiko, Kotani, Osamu, Sato, Hironori, Sekimukai, Hanako, Fukushi, Shuetsu, Suzuki, Tadaki, Sato, Yuko, Takeda, Makoto, Tashiro, Masato, Hasegawa, Hideki, Nagata, Noriyo
Publicado 2019

Protective effects of the Francisella tularensis ΔpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques

por Tian, Deyu, Uda, Akihiko, Ami, Yasushi, Hotta, Akitoyo, Park, Eun-sil, Nagata, Noriyo, Iwata-Yoshikawa, Naoko, Yamada, Akio, Hirayama, Kazuhiro, Miura, Kozue, Koyama, Yuki, Azaki, Mika, Morikawa, Shigeru
Publicado 2019

Characterization of novel monoclonal antibodies against the MERS-coronavirus spike protein and their application in species-independent antibody detection by competitive ELISA

por Fukushi, Shuetsu, Fukuma, Aiko, Kurosu, Takeshi, Watanabe, Shumpei, Shimojima, Masayuki, Shirato, Kazuya, Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Ohnishi, Kazuo, Ato, Manabu, Melaku, Simenew Keskes, Sentsui, Hiroshi, Saijo, Masayuki
Publicado 2018

Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model

por Ishii, Hiroshi, Matsuoka, Saori, Nomura, Takushi, Nakamura, Midori, Shiino, Teiichiro, Sato, Yuko, Iwata-Yoshikawa, Naoko, Hasegawa, Hideki, Mizuta, Kazuta, Sakawaki, Hiromi, Miura, Tomoyuki, Koyanagi, Yoshio, Naruse, Taeko K., Kimura, Akinori, Matano, Tetsuro
Publicado 2016

Efficacy of T-705 (Favipiravir) in the Treatment of Infections with Lethal Severe Fever with Thrombocytopenia Syndrome Virus

por Tani, Hideki, Fukuma, Aiko, Fukushi, Shuetsu, Taniguchi, Satoshi, Yoshikawa, Tomoki, Iwata-Yoshikawa, Naoko, Sato, Yuko, Suzuki, Tadaki, Nagata, Noriyo, Hasegawa, Hideki, Kawai, Yasuhiro, Uda, Akihiko, Morikawa, Shigeru, Shimojima, Masayuki, Watanabe, Haruo, Saijo, Masayuki
Publicado 2016

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

por Iwata-Yoshikawa, Naoko, Kakizaki, Masatoshi, Shiwa-Sudo, Nozomi, Okura, Takashi, Tahara, Maino, Fukushi, Shuetsu, Maeda, Ken, Kawase, Miyuki, Asanuma, Hideki, Tomita, Yuriko, Takayama, Ikuyo, Matsuyama, Shutoku, Shirato, Kazuya, Suzuki, Tadaki, Nagata, Noriyo, Takeda, Makoto
Publicado 2022

Impact of Reinfection with SARS-CoV-2 Omicron Variants in Previously Infected Hamsters

por Shiwa-Sudo, Nozomi, Sakai, Yusuke, Iwata-Yoshikawa, Naoko, Watanabe, Shinji, Yamada, Souichi, Kuroda, Yudai, Yamamoto, Tsukasa, Shirakura, Masayuki, Fujisaki, Seiichiro, Miyazaki, Kaya, Miura, Hideka, Nagata, Shiho, Fukushi, Shuetsu, Maeda, Ken, Hasegawa, Hideki, Suzuki, Tadaki, Nagata, Noriyo
Publicado 2023

Results from a preclinical study in rodents and a Phase 1/2, randomized, double-blind, placebo-controlled, parallel-group study of COVID-19 vaccine S-268019-a in Japanese adults

por Sonoyama, Takuhiro, Iwata, Satoshi, Shinkai, Masaharu, Iwata-Yoshikawa, Naoko, Shiwa-Sudo, Nozomi, Hemmi, Takuya, Ainai, Akira, Nagata, Noriyo, Matsunaga, Nobuaki, Tada, Yukio, Homma, Tomoyuki, Omoto, Shinya, Yokokawa Shibata, Risa, Igarashi, Kenji, Suzuki, Tadaki, Hasegawa, Hideki, Ariyasu, Mari
Publicado 2023

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

por Hemmi, Takuya, Ainai, Akira, Hashiguchi, Takao, Tobiume, Minoru, Kanno, Takayuki, Iwata-Yoshikawa, Naoko, Iida, Shun, Sato, Yuko, Miyamoto, Sho, Ueno, Akira, Sano, Kaori, Saito, Shinji, Shiwa-Sudo, Nozomi, Nagata, Noriyo, Tamura, Koji, Suzuki, Ryosuke, Hasegawa, Hideki, Suzuki, Tadaki
Publicado 2022

2141. Preclinical Evaluation of PA-001: A Novel, Potential Macrocyclic Peptide-Based Treatment for COVID-19 Which Binds to the S2 Subunit of SARS-CoV-2 Spike Protein

por Kawamura, Tatsuro, Ohuchi, Masaki, Nagasawa, Takayuki, Ohashi, Hirofumi, Iwata-Yoshikawa, Naoko, Shiwa-Sudo, Nozomi, Sakai, Yusuke, Matsui, Katsuma, Matsumoto, Masatoshi, Kurasaki, Haruaki, Nagatomo, Kazutaka, Ito, Shoko, Kawamura, Naoki, Masuya, Keiichi, Nagata, Noriyo, Watashi, Koichi, Suzuki, Tadaki, Kitamura, Hidetomo, Murakami, Masato
Publicado 2023