Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application

por Sinha, Sanjay, Iyer, Dharini, Granata, Alessandra
Publicado 2014

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells

por Iyer, Dharini, Gambardella, Laure, Bernard, William G., Serrano, Felipe, Mascetti, Victoria L., Pedersen, Roger A., Talasila, Amarnath, Sinha, Sanjay
Publicado 2015

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells

por Iyer, Dharini, Gambardella, Laure, Bernard, William G., Serrano, Felipe, Mascetti, Victoria L., Pedersen, Roger A., Sinha, Sanjay, Talasila, Amarnath
Publicado 2016

A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration

por Serrano, Felipe, Bernard, William George, Granata, Alessandra, Iyer, Dharini, Steventon, Ben, Kim, Matthew, Vallier, Ludovic, Gambardella, Laure, Sinha, Sanjay
Publicado 2019

Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping

por Zhao, Quanyi, Dacre, Michael, Nguyen, Trieu, Pjanic, Milos, Liu, Boxiang, Iyer, Dharini, Cheng, Paul, Wirka, Robert, Kim, Juyong Brian, Fraser, Hunter B., Quertermous, Thomas
Publicado 2020

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

por Iyer, Dharini, Zhao, Quanyi, Wirka, Robert, Naravane, Ameay, Nguyen, Trieu, Liu, Boxiang, Nagao, Manabu, Cheng, Paul, Miller, Clint L., Kim, Juyong Brian, Pjanic, Milos, Quertermous, Thomas
Publicado 2018

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

por Kim, Juyong Brian, Pjanic, Milos, Nguyen, Trieu, Miller, Clint L., Iyer, Dharini, Liu, Boxiang, Wang, Ting, Sazonova, Olga, Carcamo-Orive, Ivan, Matic, Ljubica Perisic, Maegdefessel, Lars, Hedin, Ulf, Quertermous, Thomas
Publicado 2017

Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque

por Cheng, Paul, Wirka, Robert C., Kim, Juyong Brian, Kim, Hyun-Jung, Nguyen, Trieu, Kundu, Ramendra, Zhao, Quanyi, Sharma, Disha, Pedroza, Albert, Nagao, Manabu, Iyer, Dharini, Fischbein, Michael P., Quertermous, Thomas
Publicado 2022

Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

por Bargehr, Johannes, Ong, Lay Ping, Colzani, Maria, Davaapil, Hongorzul, Hofsteen, Peter, Bhandari, Shiv, Gambardella, Laure, Novère, Nicolas Le, Iyer, Dharini, Sampaziotis, Fotios, Weinberger, Florian, Bertero, Alessandro, Leonard, Andrea, Bernard, William G, Martinson, Amy, Figg, Nichola, Regnier, Michael, Bennett, Martin R, Murry, Charles E, Sinha, Sanjay
Publicado 2019

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs

por Bertero, Alessandro, Pawlowski, Matthias, Ortmann, Daniel, Snijders, Kirsten, Yiangou, Loukia, Cardoso de Brito, Miguel, Brown, Stephanie, Bernard, William G., Cooper, James D., Giacomelli, Elisa, Gambardella, Laure, Hannan, Nicholas R. F., Iyer, Dharini, Sampaziotis, Fotios, Serrano, Felipe, Zonneveld, Mariëlle C. F., Sinha, Sanjay, Kotter, Mark, Vallier, Ludovic
Publicado 2016