Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells

por Carlsten, Mattias, Järås, Marcus
Publicado 2019

Secreted cystatins decrease proliferation and enhance apoptosis of human leukemic cells

por Hunaiti, Samar, Wallin, Hanna, Eriksson, Mia, Järås, Marcus, Abrahamson, Magnus
Publicado 2020

Interleukin 4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation

por Peña-Martínez, Pablo, Ramakrishnan, Ramprasad, Högberg, Carl, Jansson, Caroline, Nord, David Gisselsson, Järås, Marcus
Publicado 2021

Sister chromatid cohesion defects are associated with chromosomal copy number heterogeneity in high hyperdiploid childhood acute lymphoblastic leukemia

por Moura‐Castro, Larissa H., Peña‐Martínez, Pablo, Castor, Anders, Galeev, Roman, Larsson, Jonas, Järås, Marcus, Yang, Minjun, Paulsson, Kajsa
Publicado 2021

CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting

por Landberg, Niklas, von Palffy, Sofia, Askmyr, Maria, Lilljebjörn, Henrik, Sandén, Carl, Rissler, Marianne, Mustjoki, Satu, Hjorth-Hansen, Henrik, Richter, Johan, Ågerstam, Helena, Järås, Marcus, Fioretos, Thoas
Publicado 2018

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

por Chapellier, Marion, Peña-Martínez, Pablo, Ramakrishnan, Ramprasad, Eriksson, Mia, Talkhoncheh, Mehrnaz Safaee, Orsmark-Pietras, Christina, Lilljebjörn, Henrik, Högberg, Carl, Hagström-Andersson, Anna, Fioretos, Thoas, Larsson, Jonas, Järås, Marcus
Publicado 2019

Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity

por Mattebo, Alexander, Sen, Taha, Jassinskaja, Maria, Pimková, Kristýna, Prieto González-Albo, Isabel, Alattar, Abdul Ghani, Ramakrishnan, Ramprasad, Lang, Stefan, Järås, Marcus, Hansson, Jenny, Soneji, Shamit, Singbrant, Sofie, van den Akker, Emile, Flygare, Johan
Publicado 2021

FLT3(N676K) drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis

por Hyrenius-Wittsten, Axel, Pilheden, Mattias, Falqués-Costa, Antoni, Eriksson, Mia, Sturesson, Helena, Schneider, Pauline, Wander, Priscilla, Garcia-Ruiz, Cristian, Liu, Jian, Ågerstam, Helena, Hultquist, Anne, Lilljebjörn, Henrik, Stam, Ronald W., Järås, Marcus, Hagström-Andersson, Anna K.
Publicado 2019

A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells

por von Palffy, Sofia, Landberg, Niklas, Sandén, Carl, Zacharaki, Dimitra, Shah, Mansi, Nakamichi, Naoto, Hansen, Nils, Askmyr, Maria, Lilljebjörn, Henrik, Rissler, Marianne, Karlsson, Christine, Scheding, Stefan, Richter, Johan, Eaves, Connie J., Bhatia, Ravi, Järås, Marcus, Fioretos, Thoas
Publicado 2020

CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

por Ramakrishnan, Ramprasad, Peña-Martínez, Pablo, Agarwal, Puneet, Rodriguez-Zabala, Maria, Chapellier, Marion, Högberg, Carl, Eriksson, Mia, Yudovich, David, Shah, Mansi, Ehinger, Mats, Nilsson, Björn, Larsson, Jonas, Hagström-Andersson, Anna, Ebert, Benjamin L., Bhatia, Ravi, Järås, Marcus
Publicado 2020

The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML

por von Palffy, Sofia, Thorsson, Hanna, Peña-Martínez, Pablo, Puente-Moncada, Noelia, Sandén, Carl, Blom, Anna M., Henningsson, Rasmus, Juliusson, Gunnar, King, Ben, Landberg, Niklas, Lazarevic, Vladimir, Orsmark-Pietras, Christina, Rissler, Marianne, Rissler, Vendela, Ågerstam, Helena, Järås, Marcus, Lilljebjörn, Henrik, Fioretos, Thoas
Publicado 2022

Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity

por Rodriguez-Zabala, Maria, Ramakrishnan, Ramprasad, Reinbach, Katrin, Ghosh, Somadri, Oburoglu, Leal, Falqués-Costa, Antoni, Bellamkonda, Kishan, Ehinger, Mats, Peña-Martínez, Pablo, Puente-Moncada, Noelia, Lilljebjörn, Henrik, Cammenga, Jörg, Pronk, Cornelis Jan, Lazarevic, Vladimir, Fioretos, Thoas, Hagström-Andersson, Anna K., Woods, Niels-Bjarne, Järås, Marcus
Publicado 2023

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

por Järås, Marcus, Miller, Peter G., Chu, Lisa P., Puram, Rishi V., Fink, Emma C., Schneider, Rebekka K., Al-Shahrour, Fatima, Peña, Pablo, Breyfogle, L. Jordan, Hartwell, Kimberly A., McConkey, Marie E., Cowley, Glenn S., Root, David E., Kharas, Michael G., Mullally, Ann, Ebert, Benjamin L.
Publicado 2014

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

por Hyrenius-Wittsten, Axel, Pilheden, Mattias, Sturesson, Helena, Hansson, Jenny, Walsh, Michael P., Song, Guangchun, Kazi, Julhash U., Liu, Jian, Ramakrishan, Ramprasad, Garcia-Ruiz, Cristian, Nance, Stephanie, Gupta, Pankaj, Zhang, Jinghui, Rönnstrand, Lars, Hultquist, Anne, Downing, James R., Lindkvist-Petersson, Karin, Paulsson, Kajsa, Järås, Marcus, Gruber, Tanja A., Ma, Jing, Hagström-Andersson, Anna K.
Publicado 2018

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

por Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D.R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.
Publicado 2015

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

por Vu, Ly P., Prieto, Camila, Amin, Elianna M., Chhangawala, Sagar, Krivtsov, Andrei, Calvo-Vidal, M. Nieves, Chou, Timothy, Chow, Arthur, Minuesa, Gerard, Park, Sun Mi, Barlowe, Trevor S., Taggart, James, Tivnan, Patrick, Deering, Raquel P., Chu, Lisa P, Kwon, Jeong-Ah, Meydan, Cem, Perales-Paton, Javier, Arshi, Arora, Gönen, Mithat, Famulare, Christopher, Patel, Minal, Paietta, Elisabeth, Tallman, Martin S., Lu, Yuheng, Glass, Jacob, Garret-Bakelman, Francine, Melnick, Ari, Levine, Ross, Al-Shahrour, Fatima, Järås, Marcus, Hacohen, Nir, Hwang, Alexia, Garippa, Ralph, Lengner, Christopher J., Armstrong, Scott A, Cerchietti, Leandro, Cowley, Glenn S, Root, David, Doench, John, Leslie, Christina, Ebert, Benjamin L, Kharas, Michael G.
Publicado 2017