Distinct functions of AKT isoforms in breast cancer: a comprehensive review

por Hinz, Nico, Jücker, Manfred
Publicado 2019

AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review

por Hinz, Nico, Jücker, Manfred
Publicado 2021

The Role of mTOR Signaling as a Therapeutic Target in Cancer

por Popova, Nadezhda V., Jücker, Manfred
Publicado 2021

The Functional Role of Extracellular Matrix Proteins in Cancer

por Popova, Nadezhda V., Jücker, Manfred
Publicado 2022

The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

por Tian, Ling-Yu, Smit, Daniel J., Jücker, Manfred
Publicado 2023

"Alcohol and nicotine" − Concept and evaluation of an interdisciplinary elective course with OSPE in preclinical medical education

por Bergelt, Corinna, Lauke, Heidrun, Petersen-Ewert, Corinna, Jücker, Manfred, Bauer, Christiane K.
Publicado 2014

Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells

por Grabinski, Nicole, Ewald, Florian, Hofmann, Bianca T, Staufer, Katharina, Schumacher, Udo, Nashan, Björn, Jücker, Manfred
Publicado 2012

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

por Holler, Marina, Grottke, Astrid, Mueck, Katharina, Manes, Julia, Jücker, Manfred, Rodemann, H. Peter, Toulany, Mahmoud
Publicado 2016

Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

por Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T., Nashan, Björn, Jücker, Manfred
Publicado 2015

Akt isoform specific effects in ovarian cancer progression

por Linnerth-Petrik, Nicolle M., Santry, Lisa A., Moorehead, Roger, Jücker, Manfred, Wootton, Sarah K., Petrik, Jim
Publicado 2016

High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

por Smit, Daniel J., Cayrefourcq, Laure, Haider, Marie-Therese, Hinz, Nico, Pantel, Klaus, Alix-Panabières, Catherine, Jücker, Manfred
Publicado 2020

Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo

por Schulte, Alexander, Ewald, Florian, Spyra, Melanie, Smit, Daniel J., Jiang, Wei, Salamon, Johannes, Jücker, Manfred, Mautner, Victor-Felix
Publicado 2020

SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model

por Ehm, Patrick, Rietow, Ruth, Wegner, Wiebke, Bußmann, Lara, Kriegs, Malte, Dierck, Kevin, Horn, Stefan, Streichert, Thomas, Horstmann, Martin, Jücker, Manfred
Publicado 2023

Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer

por Schaks, Matthias, Allgoewer, Kristina, Nelson, Nina, Ehm, Patrick, Heumann, Asmus, Ewald, Florian, Schumacher, Udo, Simon, Ronald, Sauter, Guido, Jücker, Manfred
Publicado 2020

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

por Latuske, Emily-Marie, Stamm, Hauke, Klokow, Marianne, Vohwinkel, Gabi, Muschhammer, Jana, Bokemeyer, Carsten, Jücker, Manfred, Kebenko, Maxim, Fiedler, Walter, Wellbrock, Jasmin
Publicado 2017

Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis

por Hinz, Nico, Baranowsky, Anke, Horn, Michael, Kriegs, Malte, Sibbertsen, Freya, Smit, Daniel J., Clezardin, Philippe, Lange, Tobias, Schinke, Thorsten, Jücker, Manfred
Publicado 2021

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

por Grottke, Astrid, Ewald, Florian, Lange, Tobias, Nörz, Dominik, Herzberger, Christiane, Bach, Johanna, Grabinski, Nicole, Gräser, Lareen, Höppner, Frank, Nashan, Björn, Schumacher, Udo, Jücker, Manfred
Publicado 2016

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

por Elakad, Omar, Häupl, Björn, Labitzky, Vera, Yao, Sha, Küffer, Stefan, von Hammerstein-Equord, Alexander, Danner, Bernhard C., Jücker, Manfred, Urlaub, Henning, Lange, Tobias, Ströbel, Philipp, Oellerich, Thomas, Bohnenberger, Hanibal
Publicado 2022

PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression

por Hohensee, Ina, Chuang, Han-Ning, Grottke, Astrid, Werner, Stefan, Schulte, Alexander, Horn, Stefan, Lamszus, Katrin, Bartkowiak, Kai, Witzel, Isabell, Westphal, Manfred, Matschke, Jakob, Glatzel, Markus, Jücker, Manfred, Pukrop, Tobias, Pantel, Klaus, Wikman, Harriet
Publicado 2016

Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM(+) and CD90(+) Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model

por Moustafa, Mohamed, Dähling, Katarzyna-Krystyna, Günther, Armin, Riebandt, Leonie, Smit, Daniel J., Riecken, Kristoffer, Schröder, Carina, Zhuang, Ruimeng, Krech, Till, Kriegs, Malte, Fehse, Boris, Izbicki, Jakob R., Fischer, Lutz, Nashan, Björn, Li, Jun, Jücker, Manfred
Publicado 2022