Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

por Goncalves, Maria B, Clarke, Earl, Hobbs, Carl, Malmqvist, Tony, Deacon, Robert, Jack, Julian, Corcoran, Jonathan P T
Publicado 2013

Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells

por Goncalves, Maria B., Wu, Yue, Clarke, Earl, Grist, John, Hobbs, Carl, Trigo, Diogo, Jack, Julian, Corcoran, Jonathan P.T.
Publicado 2019

RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms

por Goncalves, Maria B., Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M., Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P.T.
Publicado 2019

Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury

por Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher I., Barret Kalindjian, S., Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publicado 2019

Corrigendum to “Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury” [Bioorg. Med. Chem. Lett. 2...

por Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher I., Kalindjian, S. Barret, Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publicado 2019