The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition

por Webley, S D, Welsh, S J, Jackman, A L, Aherne, G W
Publicado 2001

Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.

por Freemantle, S. J., Jackman, A. L., Kelland, L. R., Calvert, A. H., Lunec, J.
Publicado 1995

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitorD9331

por Webley, S D, Hardcastle, A, Ladner, R D, Jackman, A L, Aherne, G W
Publicado 2000

The renal effects of the water-soluble, non-folylpolyglutamate synthetase-dependent thymidylate synthase inhibitor ZD9331 in mice.

por Walton, M. I., Mitchell, F., Aherne, G. W., Medlow, C. J., Boyle, F. T., Jackman, A. L.
Publicado 1998

A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

por Skelton, L A, Ormerod, M G, Titley, J, Kimbell, R, Brunton, L A, Jackman, A L
Publicado 1999

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.

por Jackman, A. L., Kelland, L. R., Kimbell, R., Brown, M., Gibson, W., Aherne, G. W., Hardcastle, A., Boyle, F. T.
Publicado 1995

Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models.

por Aherne, G. W., Ward, E., Lawrence, N., Dobinson, D., Clarke, S. J., Musgrove, H., Sutcliffe, F., Stephens, T., Jackman, A. L.
Publicado 1998