Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

por Jackrel, Meredith E., Shorter, James
Publicado 2014

Engineering enhanced protein disaggregases for neurodegenerative disease

por Jackrel, Meredith E, Shorter, James
Publicado 2015

Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease

por Jackrel, Meredith E., Shorter, James
Publicado 2017

Prion-Like Proteins in Phase Separation and Their Link to Disease

por Sprunger, Macy L., Jackrel, Meredith E.
Publicado 2021

Monitoring condensate dynamics in S. cerevisiae using fluorescence recovery after photobleaching

por Sprunger, Macy L., Jackrel, Meredith E.
Publicado 2022

Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology

por Sprunger, Macy L., Lee, Ken, Sohn, Brian S., Jackrel, Meredith E.
Publicado 2022

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

por Yasuda, Kyota, Clatterbuck-Soper, Sarah F., Jackrel, Meredith E., Shorter, James, Mili, Stavroula
Publicado 2017

Functional analysis of proposed substrate-binding residues of Hsp104

por Howard, Matthew K., Sohn, Brian S., von Borcke, Julius, Xu, Andy, Jackrel, Meredith E.
Publicado 2020

Probing the drivers of Staphylococcus aureus biofilm protein amyloidogenesis and disrupting biofilms with engineered protein disaggregases

por Howard, Matthew K., Miller, Karlie R., Sohn, Brian S., Ryan, Jeremy J., Xu, Andy, Jackrel, Meredith E.
Publicado 2023

HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent

por Chen, Sheng, Puri, Anuradhika, Bell, Braxton, Fritsche, Joseph, Palacios, Hector, Balch, Maurie, Sprunger, Macy, Howard, Matthew, Patterson, Jessica, Patti, Gary, Davis, Albert, Jackrel, Meredith
Publicado 2023

Therapeutic genetic variation revealed in diverse Hsp104 homologs

por March, Zachary M, Sweeney, Katelyn, Kim, Hanna, Yan, Xiaohui, Castellano, Laura M, Jackrel, Meredith E, Lin, JiaBei, Chuang, Edward, Gomes, Edward, Willicott, Corey W, Michalska, Karolina, Jedrzejczak, Robert P, Joachimiak, Andrzej, Caldwell, Kim A, Caldwell, Guy A, Shalem, Ophir, Shorter, James
Publicado 2020

MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice

por Kim, Yeawon, Li, Chuang, Gu, Chenjian, Fang, Yili, Tycksen, Eric, Puri, Anuradhika, Pietka, Terri A., Sivapackiam, Jothilingam, Kidd, Kendrah, Park, Sun-Ji, Johnson, Bryce G., Kmoch, Stanislav, Duffield, Jeremy S., Bleyer, Anthony J., Jackrel, Meredith E., Urano, Fumihiko, Sharma, Vijay, Lindahl, Maria, Chen, Ying Maggie
Publicado 2023

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

por Tariq, Amber, Lin, JiaBei, Jackrel, Meredith E., Hesketh, Christina D., Carman, Peter J., Mack, Korrie L., Weitzman, Rachel, Gambogi, Craig, Murillo, Oscar A. Hernandez, Sweeny, Elizabeth A., Gurpinar, Esin, Yokom, Adam L., Gates, Stephanie N., Yee, Keolamau, Sudesh, Saurabh, Stillman, Jacob, Rizo, Alexandra N., Southworth, Daniel R., Shorter, James
Publicado 2019