CasDinG is a 5′-3′ dsDNA and RNA/DNA helicase with three accessory domains essential for type IV CRISPR immunity

por Domgaard, Hannah, Cahoon, Christian, Armbrust, Matthew J, Redman, Olivine, Jolley, Alivia, Thomas, Aaron, Jackson, Ryan N
Publicado 2023

Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli

por van Erp, Paul B.G., Jackson, Ryan N., Carter, Joshua, Golden, Sarah M., Bailey, Scott, Wiedenheft, Blake
Publicado 2015

Positioning Diverse Type IV Structures and Functions Within Class 1 CRISPR-Cas Systems

por Taylor, Hannah N., Laderman, Eric, Armbrust, Matt, Hallmark, Thomson, Keiser, Dylan, Bondy-Denomy, Joseph, Jackson, Ryan N.
Publicado 2021

RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2

por Bravo, Jack P. K., Hallmark, Thomson, Naegle, Bronson, Beisel, Chase L., Jackson, Ryan N., Taylor, David W.
Publicado 2023

Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

por Westra, Edze R., Semenova, Ekaterina, Datsenko, Kirill A., Jackson, Ryan N., Wiedenheft, Blake, Severinov, Konstantin, Brouns, Stan J. J.
Publicado 2013

Role of nucleotide identity in effective CRISPR target escape mutations

por Künne, Tim, Zhu, Yifan, da Silva, Fausia, Konstantinides, Nico, McKenzie, Rebecca E, Jackson, Ryan N, Brouns, Stan JJ
Publicado 2018

The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding

por Taylor, Lacy L., Jackson, Ryan N., Rexhepaj, Megi, King, Alejandra Klauer, Lott, Lindsey K., van Hoof, Ambro, Johnson, Sean J.
Publicado 2014

Structure of a type IV CRISPR-Cas ribonucleoprotein complex

por Zhou, Yi, Bravo, Jack P.K., Taylor, Hannah N., Steens, Jurre A., Jackson, Ryan N., Staals, Raymond H.J., Taylor, David W.
Publicado 2021

The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers

por Luo, Michelle L., Jackson, Ryan N., Denny, Steven R., Tokmina-Lukaszewska, Monika, Maksimchuk, Kenneth R., Lin, Wayne, Bothner, Brian, Wiedenheft, Blake, Beisel, Chase L.
Publicado 2016

Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA

por Dmytrenko, Oleg, Neumann, Gina C., Hallmark, Thomson, Keiser, Dylan J., Crowley, Valerie M., Vialetto, Elena, Mougiakos, Ioannis, Wandera, Katharina G., Domgaard, Hannah, Weber, Johannes, Gaudin, Thomas, Metcalf, Josie, Gray, Benjamin N., Begemann, Matthew B., Jackson, Ryan N., Beisel, Chase L.
Publicado 2023