The AAA+ protease ClpXP can easily degrade a 3(1) and a 5(2)-knotted protein

por Sivertsson, Elin M., Jackson, Sophie E., Itzhaki, Laura S.
Publicado 2019

Distinct Mechanisms of Calmodulin Binding and Regulation of Adenylyl Cyclases 1 and 8

por Masada, Nanako, Schaks, Sabine, Jackson, Sophie E., Sinz, Andrea, Cooper, Dermot M. F.
Publicado 2012

Identification of macrocyclic peptides which activate bacterial cylindrical proteases

por Walther, Raoul, Westermann, Linda M., Carmali, Sheiliza, Jackson, Sophie E., Brötz-Oesterhelt, Heike, Spring, David R.
Publicado 2023

Toward Rapid Aspartic Acid Isomer Localization in Therapeutic Peptides Using Cyclic Ion Mobility Mass Spectrometry

por Gibson, Katherine, Cooper-Shepherd, Dale A., Pallister, Edward, Inman, Sophie E., Jackson, Sophie E., Lindo, Viv
Publicado 2022

The Amyloid Fibril-Forming β-Sheet Regions of Amyloid β and α-Synuclein Preferentially Interact with the Molecular Chaperone 14-3-3ζ

por Williams, Danielle M., Thorn, David C., Dobson, Christopher M., Meehan, Sarah, Jackson, Sophie E., Woodcock, Joanna M., Carver, John A.
Publicado 2021

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

por Kundel, Franziska, De, Suman, Flagmeier, Patrick, Horrocks, Mathew H., Kjaergaard, Magnus, Shammas, Sarah L., Jackson, Sophie E., Dobson, Christopher M., Klenerman, David
Publicado 2018

De novo design of knotted tandem repeat proteins

por Doyle, Lindsey A., Takushi, Brittany, Kibler, Ryan D., Milles, Lukas F., Orozco, Carolina T., Jones, Jonathan D., Jackson, Sophie E., Stoddard, Barry L., Bradley, Philip
Publicado 2023

Ubiquitin chain conformation regulates recognition and activity of interacting proteins

por Ye, Yu, Blaser, Georg, Horrocks, Mathew H., Ruedas-Rama, Maria J., Ibrahim, Shehu, Zhukov, Alexander A., Orte, Angel, Klenerman, David, Jackson, Sophie E., Komander, David
Publicado 2012

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

por Dannheim, Friederike M., Walsh, Stephen J., Orozco, Carolina T., Hansen, Anders Højgaard, Bargh, Jonathan D., Jackson, Sophie E., Bond, Nicholas J., Parker, Jeremy S., Carroll, Jason S., Spring, David R.
Publicado 2022

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

por Morgner, Nina, Schmidt, Carla, Beilsten-Edmands, Victoria, Ebong, Ima-obong, Patel, Nisha A., Clerico, Eugenia M., Kirschke, Elaine, Daturpalli, Soumya, Jackson, Sophie E., Agard, David, Robinson, Carol V.
Publicado 2015

Mechanistic insights into the rational design of masked antibodies

por Orozco, Carolina T., Bersellini, Manuela, Irving, Lorraine M., Howard, Wesley W., Hargreaves, David, Devine, Paul W. A., Siouve, Elise, Browne, Gareth J., Bond, Nicholas J., Phillips, Jonathan J., Ravn, Peter, Jackson, Sophie E.
Publicado 2022