A versatile, high-efficiency platform for CRISPR-based gene activation

por Heidersbach, Amy J., Dorighi, Kristel M., Gomez, Javier A., Jacobi, Ashley M., Haley, Benjamin
Publicado 2023

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3′ Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs

por Zhou, Jiehua, Song, Min-Sun, Jacobi, Ashley M, Behlke, Mark A, Wu, Xiwei, Rossi, John J
Publicado 2012

Kir3 channel ontogeny – the role of Gβγ subunits in channel assembly and trafficking

por Zylbergold, Peter, Sleno, Rory, Khan, Shahriar M., Jacobi, Ashley M., Belhke, Mark A., Hébert, Terence E.
Publicado 2014

Tumor Apolipoprotein E is a key checkpoint blocking anti-tumor immunity in mouse melanoma

por Wu, Xiaofang, Srinivasan, Priya, Basu, Mousumi, Zhang, Peng, Saruwatari, Michele, Thommandru, Bernice, Jacobi, Ashley, Behlke, Mark, Sandler, Anthony
Publicado 2022

RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma

por Weinstein, Shiri, Emmanuel, Rafi, Jacobi, Ashley M., Abraham, Avigdor, Behlke, Mark A., Sprague, Andrew G., Novobrantseva, Tatiana I., Nagler, Arnon, Peer, Dan
Publicado 2012

Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development

por Bégin-Lavallée, Valérie, Midavaine, Élora, Dansereau, Marc-André, Tétreault, Pascal, Longpré, Jean-Michel, Jacobi, Ashley M, Rose, Scott D, Behlke, Mark A, Beaudet, Nicolas, Sarret, Philippe
Publicado 2016

Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System

por Shapiro, Jenny, Iancu, Ortal, Jacobi, Ashley M., McNeill, Matthew S., Turk, Rolf, Rettig, Garrett R., Amit, Ido, Tovin-Recht, Adi, Yakhini, Zohar, Behlke, Mark A., Hendel, Ayal
Publicado 2020

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

por Kow, Rebecca L., Strovas, Timothy J., McMillan, Pamela J., Jacobi, Ashley M., Behlke, Mark A., Saxton, Aleen D., Latimer, Caitlin S., Keene, C. Dirk, Kraemer, Brian C.
Publicado 2020

T-cell activation is enhanced by targeting IL-10 cytokine production in toll-like receptor-stimulated macrophages

por Walk, Ryan M, Elliott, Steven T, Blanco, Felix C, Snyder, Jason A, Jacobi, Ashley M, Rose, Scott D, Behlke, Mark A, Salem, Aliasger K, Vukmanovic, Stanislav, Sandler, Anthony D
Publicado 2012

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

por Rosenblum, Daniel, Gutkin, Anna, Kedmi, Ranit, Ramishetti, Srinivas, Veiga, Nuphar, Jacobi, Ashley M., Schubert, Mollie S., Friedmann-Morvinski, Dinorah, Cohen, Zvi R., Behlke, Mark A., Lieberman, Judy, Peer, Dan
Publicado 2020

CRISPAltRations: a validated cloud-based approach for interrogation of double-strand break repair mediated by CRISPR genome editing

por Kurgan, Gavin, Turk, Rolf, Li, Heng, Roberts, Nathan, Rettig, Garrett R., Jacobi, Ashley M., Tso, Lauren, Sturgeon, Morgan, Mertens, Massimo, Noten, Roel, Florus, Kurt, Behlke, Mark A., Wang, Yu, McNeill, Matthew S.
Publicado 2021

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes

por Jacobi, Ashley M., Rettig, Garrett R., Turk, Rolf, Collingwood, Michael A., Zeiner, Sarah A., Quadros, Rolen M., Harms, Donald W., Bonthuis, Paul J., Gregg, Christopher, Ohtsuka, Masato, Gurumurthy, Channabasavaiah B., Behlke, Mark A.
Publicado 2017

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides

por Hammond, Suzan M, McClorey, Graham, Nordin, Joel Z, Godfrey, Caroline, Stenler, Sofia, Lennox, Kim A, Smith, CI Edvard, Jacobi, Ashley M, Varela, Miguel A, Lee, Yi, Behlke, Mark A, Wood, Matthew J A, Andaloussi, Samir E L
Publicado 2014

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein

por Dewari, Pooran Singh, Southgate, Benjamin, Mccarten, Katrina, Monogarov, German, O'Duibhir, Eoghan, Quinn, Niall, Tyrer, Ashley, Leitner, Marie-Christin, Plumb, Colin, Kalantzaki, Maria, Blin, Carla, Finch, Rebecca, Bressan, Raul Bardini, Morrison, Gillian, Jacobi, Ashley M, Behlke, Mark A, von Kriegsheim, Alex, Tomlinson, Simon, Krijgsveld, Jeroen, Pollard, Steven M
Publicado 2018

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human haematopoietic stem and progenitor cells

por Vakulskas, Christopher A., Dever, Daniel P., Rettig, Garrett R., Turk, Rolf, Jacobi, Ashley M., Collingwood, Michael A., Bode, Nicole M., McNeill, Matthew S., Yan, Shuqi, Camarena, Joab, Lee, Ciaran M., Park, So Hyun, Wiebking, Volker, Bak, Rasmus O., Gomez-Ospina, Natalia, Pavel-Dinu, Mara, Sun, Wenchao, Bao, Gang, Porteus, Matthew H., Behlke, Mark A.
Publicado 2018

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

por Quadros, Rolen M., Miura, Hiromi, Harms, Donald W., Akatsuka, Hisako, Sato, Takehito, Aida, Tomomi, Redder, Ronald, Richardson, Guy P., Inagaki, Yutaka, Sakai, Daisuke, Buckley, Shannon M., Seshacharyulu, Parthasarathy, Batra, Surinder K., Behlke, Mark A., Zeiner, Sarah A., Jacobi, Ashley M., Izu, Yayoi, Thoreson, Wallace B., Urness, Lisa D., Mansour, Suzanne L., Ohtsuka, Masato, Gurumurthy, Channabasavaiah B.
Publicado 2017

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells

por Kath, Jonas, Du, Weijie, Pruene, Alina, Braun, Tobias, Thommandru, Bernice, Turk, Rolf, Sturgeon, Morgan L., Kurgan, Gavin L., Amini, Leila, Stein, Maik, Zittel, Tatiana, Martini, Stefania, Ostendorf, Lennard, Wilhelm, Andreas, Akyüz, Levent, Rehm, Armin, Höpken, Uta E., Pruß, Axel, Künkele, Annette, Jacobi, Ashley M., Volk, Hans-Dieter, Schmueck-Henneresse, Michael, Stripecke, Renata, Reinke, Petra, Wagner, Dimitrios L.
Publicado 2022