Pharmacodynamics, Safety, and Tolerability of the NHE3 Inhibitor Tenapanor: Two Trials in Healthy Volunteers

por Rosenbaum, David P., Yan, Andrew, Jacobs, Jeffrey W.
Publicado 2018

Novel Treatments from Inhibition of the Intestinal Sodium–Hydrogen Exchanger 3

por Kovesdy, Csaba P, Adebiyi, Adebowale, Rosenbaum, David, Jacobs, Jeffrey W, Quarles, L Darryl
Publicado 2021

Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice

por Davidson, James P., King, Andrew J., Kumaraswamy, Padmapriya, Caldwell, Jeremy S., Korner, Paul, Blanks, Robert C., Jacobs, Jeffrey W.
Publicado 2017

Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate

por Zann, Vanessa, McDermott, John, Jacobs, Jeffrey W, Davidson, James P, Lin, Fangling, Korner, Paul, Blanks, Robert C, Rosenbaum, David P
Publicado 2017

Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na(+)/H(+) Exchanger Isoform 3

por Jacobs, Jeffrey W., Leadbetter, Michael R., Bell, Noah, Koo-McCoy, Samantha, Carreras, Christopher W., He, Limin, Kohler, Jill, Kozuka, Kenji, Labonté, Eric D., Navre, Marc, Spencer, Andrew G., Charmot, Dominique
Publicado 2022

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

por Finn, Patricia D., Rodriguez, David, Kohler, Jill, Jiang, Zhengfeng, Wan, Sindy, Blanco, Erick, King, Andrew J., Chen, Tao, Bell, Noah, Dragoli, Dean, Jacobs, Jeffrey W., Jain, Rakesh, Leadbetter, Michael, Siegel, Matthew, Carreras, Christopher W., Koo-McCoy, Samantha, Shaw, Karen, Le, Cathy, Vanegas, Sandra, Hsu, I-Hsin, Kozuka, Kenji, Okamoto, Keiko, Caldwell, Jeremy S., Lewis, Jason G.
Publicado 2019