Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer

por Coates, James T., Sun, Sheng, Leshchiner, Ignaty, Thimmiah, Nayana, Martin, Elizabeth E., McLoughlin, Daniel, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Rhrissorrakrai, Kahn, Utro, Filippo, Levovitz, Chaya, Denault, Elyssa, Walmsley, Charlotte S., Kambadakone, Avinash, Stone, James R., Isakoff, Steven J., Parida, Laxmi, Juric, Dejan, Getz, Gad, Bardia, Aditya, Ellisen, Leif W.
Publicado 2021

Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance

por Naeem, Aishath, Utro, Filippo, Wang, Qing, Cha, Justin, Vihinen, Mauno, Martindale, Stephen, Zhou, Yinglu, Ren, Yue, Tyekucheva, Svitlana, Kim, Annette S., Fernandes, Stacey M., Saksena, Gordon, Rhrissorrakrai, Kahn, Levovitz, Chaya, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Davids, Matthew S., Lederer, James A., Zain, Rula, Smith, C. I. Edvard, Leshchiner, Ignaty, Parida, Laxmi, Getz, Gad, Brown, Jennifer R.
Publicado 2022

Germline mutations and developmental mosaicism underlying EGFR-mutant lung cancer

por Burr, Risa, Leshchiner, Ignaty, Costantino, Christina L, Blohmer, Martin, Sundaresan, Tilak, Cha, Justin, Seeger, Karsen, Guay, Sara, Danysh, Brian P, Gore, Ira, Jacobs, Raquel A, Slowik, Kara, Utro, Filippo, Rhrissorrakrai, Kahn, Levovitz, Chaya, Barth, Jaimie L, Dubash, Taronish, Chirn, Brian, Parida, Laxmi, Sequist, Lecia V, Lennerz, Jochen K, Mino-Kenudson, Mari, Maheswaran, Shyamala, Naxerova, Kamila, Getz, Gad, Haber, Daniel A
Publicado 2023