Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy

por Hill, Sophie F., Jafar-Nejad, Paymaan, Rigo, Frank, Meisler, Miriam H.
Publicado 2023

Gene Clusters, Molecular Evolution and Disease: A Speculation

por Elizondo, Leah I, Jafar-Nejad, Paymaan, Clewing, J. Marietta, Boerkoel, Cornelius F
Publicado 2009

Playback Theatre as a tool to enhance communication in medical education

por Salas, Ramiro, Steele, Kenya, Lin, Amy, Loe, Claire, Gauna, Leslie, Jafar-Nejad, Paymaan
Publicado 2013

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

por Gould, Stacey Anne, Gilley, Jonathan, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Coleman, Michael
Publicado 2021

Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2

por Hill, Sophie F., Ziobro, Julie M., Jafar‐Nejad, Paymaan, Rigo, Frank, Meisler, Miriam H.
Publicado 2022

Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

por Korobeynikov, Vladislav A., Lyashchenko, Alexander K., Blanco-Redondo, Beatriz, Jafar-Nejad, Paymaan, Shneider, Neil A.
Publicado 2022

Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn (R493X) mouse model of frontotemporal dementia

por Smith, Denise M., Niehoff, Michael L., Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Farr, Susan A., Wilkinson, Miles F., Nguyen, Andrew D.
Publicado 2023

Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown

por Clayton, Emma L, Milioto, Carmelo, Muralidharan, Bhavana, Norona, Frances E, Edgar, James R, Soriano, Armand, Jafar-nejad, Paymaan, Rigo, Frank, Collinge, John, Isaacs, Adrian M
Publicado 2018

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

por Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Walker, Adam K.
Publicado 2023

Pharmacometabolomic Signature of Ataxia SCA1 Mouse Model and Lithium Effects

por Perroud, Bertrand, Jafar-Nejad, Paymaan, Wikoff, William R., Gatchel, Jennifer R., Wang, Lu, Barupal, Dinesh K., Crespo-Barreto, Juan, Fiehn, Oliver, Zoghbi, Huda Y., Kaddurah-Daouk, Rima
Publicado 2013

PFTK1 kinase regulates axogenesis during development via RhoA activation

por González, Yasmilde Rodríguez, Kamkar, Fatemeh, Jafar-nejad, Paymaan, Wang, Suzi, Qu, Dianbo, Alvarez, Leticia Sanchez, Hawari, Dina, Sonnenfeld, Margaret, Slack, Ruth S., Albert, Paul R., Park, David S., Joselin, Alvin
Publicado 2023

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes

por Lasagna-Reeves, Cristian A, Rousseaux, Maxime WC, Guerrero-Munoz, Marcos J, Vilanova-Velez, Luis, Park, Jeehye, See, Lauren, Jafar-Nejad, Paymaan, Richman, Ronald, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Publicado 2015

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

por Yang, Sen, Niou, Zhen-Xian, Enriquez, Andrea, LaMar, Jacob, Huang, Jui-Yen, Ling, Karen, Jafar-Nejad, Paymaan, Gilley, Jonathan, Coleman, Michael P., Tennessen, Jason M., Rangaraju, Vidhya, Lu, Hui-Chen
Publicado 2023

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

por Lasagna-Reeves, Cristian A, Rousseaux, Maxime WC, Guerrero-Muñoz, Marcos J, Park, Jeehye, Jafar-Nejad, Paymaan, Richman, Ronald, Lu, Nan, Sengupta, Urmi, Litvinchuk, Alexandra, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Publicado 2015

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies

por Liu, Pingting, Chen, Wei, Jiang, Haowen, Huang, Haoliang, Liu, Liping, Fang, Fang, Li, Liang, Feng, Xue, Liu, Dong, Dalal, Roopa, Sun, Yang, Jafar-Nejad, Paymaan, Ling, Karen, Rigo, Frank, Ye, Jiangbin, Hu, Yang
Publicado 2023

Targeted suppression of mTORC2 reduces seizures across models of epilepsy

por Okoh, James, Mays, Jacqunae, Bacq, Alexandre, Oses-Prieto, Juan A., Tyanova, Stefka, Chen, Chien-Ju, Imanbeyev, Khalel, Doladilhe, Marion, Zhou, Hongyi, Jafar-Nejad, Paymaan, Burlingame, Alma, Noebels, Jeffrey, Baulac, Stephanie, Costa-Mattioli, Mauro
Publicado 2023

The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration

por Jafar-nejad, Paymaan, Powers, Berit, Soriano, Armand, Zhao, Hien, Norris, Daniel A, Matson, John, DeBrosse-Serra, Beatrice, Watson, Jamie, Narayanan, Padmakumar, Chun, Seung J, Mazur, Curt, Kordasiewicz, Holly, Swayze, Eric E, Rigo, Frank
Publicado 2020

Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome

por Lee, Dongwon, Chen, Wu, Kaku, Heet Naresh, Zhuo, Xinming, Chao, Eugene S, Soriano, Armand, Kuncheria, Allen, Flores, Stephanie, Kim, Joo Hyun, Rivera, Armando, Rigo, Frank, Jafar-nejad, Paymaan, Beaudet, Arthur L, Caudill, Matthew S, Xue, Mingshan
Publicado 2023

Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes

por Torazza, Carola, Provenzano, Francesca, Gallia, Elena, Cerminara, Maria, Balbi, Matilde, Bonifacino, Tiziana, Tessitore, Sara, Ravera, Silvia, Usai, Cesare, Musante, Ilaria, Puliti, Aldamaria, Van Den Bosch, Ludo, Jafar-nejad, Paymaan, Rigo, Frank, Milanese, Marco, Bonanno, Giambattista
Publicado 2023

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice

por Becker, Lindsay A., Huang, Brenda, Bieri, Gregor, Ma, Rosanna, Knowles, David A., Jafar-Nejad, Paymaan, Messing, James, Kim, Hong Joo, Soriano, Armand, Auburger, Georg, Pulst, Stefan M., Taylor, J. Paul, Rigo, Frank, Gitler, Aaron D.
Publicado 2017