Liraglutide, 7,8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model

por Seppa, Kadri, Jagomäe, Toomas, Kukker, Kaia Grete, Reimets, Riin, Pastak, Marko, Vasar, Eero, Terasmaa, Anton, Plaas, Mario
Publicado 2021

Treatment with the dual-incretin agonist DA-CH5 demonstrates potent therapeutic effect in a rat model of Wolfram Syndrome

por Jagomäe, Toomas, Gaur, Nayana, Seppa, Kadri, Reimets, Riin, Pastak, Marko, Plaas, Mihkel, Kaasik, Allen, Vasar, Eero, Plaas, Mario
Publicado 2023

Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome

por Toots, Maarja, Seppa, Kadri, Jagomäe, Toomas, Koppel, Tuuliki, Pallase, Maia, Heinla, Indrek, Terasmaa, Anton, Plaas, Mario, Vasar, Eero
Publicado 2018

Chronic Stress Alters Hippocampal Renin-Angiotensin-Aldosterone System Component Expression in an Aged Rat Model of Wolfram Syndrome

por Punapart, Marite, Reimets, Riin, Seppa, Kadri, Kirillov, Silvia, Gaur, Nayana, Eskla, Kattri-Liis, Jagomäe, Toomas, Vasar, Eero, Plaas, Mario
Publicado 2023

Alternative Promoter Use Governs the Expression of IgLON Cell Adhesion Molecules in Histogenetic Fields of the Embryonic Mouse Brain

por Jagomäe, Toomas, Singh, Katyayani, Philips, Mari-Anne, Jayaram, Mohan, Seppa, Kadri, Tekko, Triin, Gilbert, Scott F., Vasar, Eero, Lilleväli, Kersti
Publicado 2021

Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders

por Hade, Andreas-Christian, Philips, Mari-Anne, Reimann, Ene, Jagomäe, Toomas, Eskla, Kattri-Liis, Traks, Tanel, Prans, Ele, Kõks, Sulev, Vasar, Eero, Väli, Marika
Publicado 2021

The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome

por Punapart, Marite, Seppa, Kadri, Jagomäe, Toomas, Liiv, Mailis, Reimets, Riin, Kirillov, Silvia, Kaasik, Allen, Moons, Lieve, De Groef, Lies, Terasmaa, Anton, Vasar, Eero, Plaas, Mario
Publicado 2021

GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome

por Seppa, Kadri, Toots, Maarja, Reimets, Riin, Jagomäe, Toomas, Koppel, Tuuliki, Pallase, Maia, Hasselholt, Stine, Krogsbæk Mikkelsen, Maiken, Randel Nyengaard, Jens, Vasar, Eero, Terasmaa, Anton, Plaas, Mario
Publicado 2019

Hypothermia Alleviates Reductive Stress, a Root Cause of Ischemia Reperfusion Injury

por Eskla, Kattri-Liis, Vellama, Hans, Tarve, Liisi, Eichelmann, Hillar, Jagomäe, Toomas, Porosk, Rando, Oja, Vello, Rämma, Heikko, Peet, Nadežda, Laisk, Agu, Volke, Vallo, Vasar, Eero, Luuk, Hendrik
Publicado 2022

Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders

por Singh, Katyayani, Jayaram, Mohan, Kaare, Maria, Leidmaa, Este, Jagomäe, Toomas, Heinla, Indrek, Hickey, Miriam A., Kaasik, Allen, Schäfer, Michael K., Innos, Jürgen, Lilleväli, Kersti, Philips, Mari-Anne, Vasar, Eero
Publicado 2019

Early Intervention and Lifelong Treatment with GLP1 Receptor Agonist Liraglutide in a Wolfram Syndrome Rat Model with an Emphasis on Visual Neurodegeneration, Sensorineural Hearing...

por Jagomäe, Toomas, Seppa, Kadri, Reimets, Riin, Pastak, Marko, Plaas, Mihkel, Hickey, Miriam A., Kukker, Kaia Grete, Moons, Lieve, De Groef, Lies, Vasar, Eero, Kaasik, Allen, Terasmaa, Anton, Plaas, Mario
Publicado 2021

Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors

por Tekko, Triin, Lakspere, Triin, Allikalt, Anni, End, Jaanus, Kõlvart, Karl Rene, Jagomäe, Toomas, Terasmaa, Anton, Philips, Mari-Anne, Visnapuu, Tanel, Väärtnõu, Fred, Gilbert, Scott F., Rinken, Ago, Vasar, Eero, Lilleväli, Kersti
Publicado 2017

Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration

por Plaas, Mario, Seppa, Kadri, Reimets, Riin, Jagomäe, Toomas, Toots, Maarja, Koppel, Tuuliki, Vallisoo, Tuuli, Nigul, Mait, Heinla, Indrek, Meier, Riho, Kaasik, Allen, Piirsoo, Andres, Hickey, Miriam A., Terasmaa, Anton, Vasar, Eero
Publicado 2017

VHL-deficiency leads to reductive stress in renal cells

por Vellama, Hans, Eskla, Kattri-Liis, Eichelmann, Hillar, Hüva, Andria, Tennant, Daniel A., Thakker, Alpesh, Roberts, Jennie, Jagomäe, Toomas, Porosk, Rando, Laisk, Agu, Oja, Vello, Rämma, Heikko, Volke, Vallo, Vasar, Eero, Luuk, Hendrik
Publicado 2023

High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice

por Kaare, Maria, Mikheim, Kaie, Lilleväli, Kersti, Kilk, Kalle, Jagomäe, Toomas, Leidmaa, Este, Piirsalu, Maria, Porosk, Rando, Singh, Katyayani, Reimets, Riin, Taalberg, Egon, Schäfer, Michael K. E., Plaas, Mario, Vasar, Eero, Philips, Mari-Anne
Publicado 2021

Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice

por Kaare, Maria, Jayaram, Mohan, Jagomäe, Toomas, Singh, Katyayani, Kilk, Kalle, Mikheim, Kaie, Leevik, Marko, Leidmaa, Este, Varul, Jane, Nõmm, Helis, Rähn, Kristi, Visnapuu, Tanel, Plaas, Mario, Lilleväli, Kersti, Schäfer, Michael K. E., Philips, Mari-Anne, Vasar, Eero
Publicado 2022