A phase 1 evaluation of the pharmacokinetic/pharmacodynamic interaction of the anti-malarial agents KAF156 and piperaquine

por Leong, F. Joel, Jain, Jay Prakash, Feng, Yiyan, Goswami, Budhaditya, Stein, Daniel S.
Publicado 2018

Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects

por Jain, Jay Prakash, Lakshminarayana, Suresh B, Lefèvre, Gilbert, Sivasubramanian, Rama, Blasco, Francesca, Sunkara, Gangadhar
Publicado 2012

Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem®) for bioequivalence in a randomized, open-label, two-period study

por Lefèvre, Gilbert, Bhad, Prafulla, Jain, Jay Prakash, Kalluri, Sampath, Cheng, Yi, Dave, Hardik, Stein, Daniel S
Publicado 2013

A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel spiroindolone KAE609, to assess the safety, tolerability and...

por Leong, Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry, Pertel, Peter
Publicado 2014

A phase 1 evaluation of the pharmacokinetic/pharmacodynamic interaction of the antimalarial agents KAE609 and piperaquine (PPQ)

por Stein, Daniel S, Jain, Jay Prakash, Lickliter, Jason, Kangas, Michael, Machineni, Surendra, Griffin, Paul, Lefevre, Gilbert
Publicado 2014

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its...

por Leong, F. Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter
Publicado 2014

Bioavailability of Lumefantrine Is Significantly Enhanced with a Novel Formulation Approach, an Outcome from a Randomized, Open-Label Pharmacokinetic Study in Healthy Volunteers

por Jain, Jay Prakash, Leong, F. Joel, Chen, Lan, Kalluri, Sampath, Koradia, Vishal, Stein, Daniel S., Wolf, Marie-Christine, Sunkara, Gangadhar, Kota, Jagannath
Publicado 2017

Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium falciparum Malaria

por Hien, Tran Tinh, White, Nicholas J., Thuy-Nhien, Nguyen Thanh, Hoa, Nhu Thi, Thuan, Phung Duc, Tarning, Joel, Nosten, François, Magnusson, Baldur, Jain, Jay Prakash, Hamed, Kamal
Publicado 2017

Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coart...

por Tiono, Alfred B, Tinto, Halidou, Alao, Maroufou J, Meremikwu, Martin, Tshefu, Antoinette, Ogutu, Bernhards, Ouedraogo, Alphonse, Lingani, Moussa, Cousin, Marc, Lefèvre, Gilbert, Jain, Jay Prakash, Duparc, Stephan, Hamed, Kamal
Publicado 2015

Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Sahar...

por Ndayisaba, Gilles, Yeka, Adoke, Asante, Kwaku Poku, Grobusch, Martin P., Karita, Etienne, Mugerwa, Henry, Asiimwe, Stephen, Oduro, Abraham, Fofana, Bakary, Doumbia, Seydou, Jain, Jay Prakash, Barsainya, Sarita, Kullak-Ublick, Gerd A., Su, Guoqin, Schmitt, Esther K., Csermak, Katalin, Gandhi, Preetam, Hughes, David
Publicado 2021

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncompl...

por Taft, Benjamin R., Yokokawa, Fumiaki, Kirrane, Tom, Mata, Anne-Catherine, Huang, Richard, Blaquiere, Nicole, Waldron, Grace, Zou, Bin, Simon, Oliver, Vankadara, Subramanyam, Chan, Wai Ling, Ding, Mei, Sim, Sandra, Straimer, Judith, Guiguemde, Armand, Lakshminarayana, Suresh B., Jain, Jay Prakash, Bodenreider, Christophe, Thompson, Christopher, Lanshoeft, Christian, Shu, Wei, Fang, Eric, Qumber, Jafri, Chan, Katherine, Pei, Luying, Chen, Yen-Liang, Schulz, Hanna, Lim, Jessie, Abas, Siti Nurdiana, Ang, Xiaoman, Liu, Yugang, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Gamo, Francisco Javier, Crespo-Fernandez, Benigno, Rosenthal, Philip J., Cooper, Roland A., Tumwebaze, Patrick, Aguiar, Anna Caroline Campos, Campo, Brice, Campbell, Simon, Wagner, Jürgen, Diagana, Thierry T., Sarko, Christopher
Publicado 2022