Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity

por Joharapurkar, Amit A, Dhanesha, Nirav A, Jain, Mukul R
Publicado 2014

Pharmacokinetics, Safety, and Tolerability of Saroglitazar (ZYH1), a Predominantly PPARα Agonist with Moderate PPARγ Agonist Activity in Healthy Human Subjects

por Jani, Rajendra H., Kansagra, Kevinkumar, Jain, Mukul R., Patel, Harilal
Publicado 2013

Use of Aspirin in normalization of recombinant human erythropoietin-mediated hyper-reactivity of platelets in rats

por Soni, Hitesh M., Vekaria, Amit M., Rath, Akshyaya C., Belemkar, Sateesh, Jain, Mukul R.
Publicado 2014

Effects of combination of aliskiren and pentoxyfylline on renal function in the rat remnant kidney model of chronic renal failure

por Soni, Hitesh M., Patel, Praful P., Patel, Savan, Rath, Akshyaya C., Acharya, Aviseka, Trivedi, Harshkant D., Jain, Mukul R.
Publicado 2015

Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity

por Mishra, Vinay, Ghumatkar, Priya, Patel, Maulik V., Devada, Shilpesh, Ranvir, Ramchandra, Swain, Prabodha, Sundar, Rajesh, Bahekar, Rajesh, Jain, Mukul R.
Publicado 2011

Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models

por Jain, Mukul R, Giri, Suresh R, Trivedi, Chitrang, Bhoi, Bibhuti, Rath, Akshyaya, Vanage, Geeta, Vyas, Purvi, Ranvir, Ramchandra, Patel, Pankaj R
Publicado 2015

Prolyl hydroxylase inhibitor desidustat improves anemia in erythropoietin hyporesponsive state

por Joharapurkar, Amit A., Patel, Vishal J., Kshirsagar, Samadhan G., Patel, Maulik S., Savsani, Hardikkumar H., Kajavadara, Chetan, Valani, Darshan, Jain, Mukul R.
Publicado 2022

Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor

por Agarwal, Sameer, Pethani, Jignesh P., Shah, Hardik A., Vyas, Vismit, Sasane, Santosh, Bhavsar, Harsh, Bandyopadhyay, Debdutta, Giri, Poonam, Viswanathan, Kasinath, Jain, Mukul R., Sharma, Rajiv
Publicado 2020

Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

por Patel, Vishal J, Joharapurkar, Amit A, Kshirsagar, Samadhan G, Sutariya, Brijesh K, Patel, Maulik S, Patel, Hiren M, Pandey, Dheerendra K, Bahekar, Rajesh H, Jain, Mukul R
Publicado 2018

Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, hig...

por Giri, Suresh R., Bhoi, Bibhuti, Trivedi, Chitrang, Rath, Akshyaya, Rathod, Rohan, Sharma, Anish, Ranvir, Ramchandra, Kadam, Shekhar, Ingale, Kailash, Patel, Hiren, Nyska, Abraham, Jain, Mukul R.
Publicado 2023

Differential effects of dexamethasone and rosiglitazone in a sephadex-induced model of lung inflammation in rats: Possible role of tissue inhibitor of metalloproteinase-3

por Nagar, Jignesh K., Patel, Praful P., Mohapatra, Jogeswar N., Sharma, Manoranjan M., Pandya, Gaurav M., Umar, Malik M., Chatterjee, Abhijit A., Deshpande, Shrikalp S., Jain, Mukul R., Soni, Hitesh M.
Publicado 2015

The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

por Kumar, Divya P., Caffrey, Rebecca, Marioneaux, Jonathon, Santhekadur, Prasanna K., Bhat, Madhavi, Alonso, Cristina, Koduru, Srinivas V., Philip, Binu, Jain, Mukul R., Giri, Suresh R., Bedossa, Pierre, Sanyal, Arun J.
Publicado 2020

Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques (Macaca mulatta)

por Shah, Niraj A., Bhatt, Laxit K., Patel, Rajesh J., Patel, Tushar M., Patel, Nayankumar V., Trivedi, Harshida G., Patel, Nilam R., Patel, Jitendra H., Patel, Satish D., Sundar, Rajesh S., Jain, Mukul R.
Publicado 2022

Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models

por Jain, Mukul R., Giri, Suresh R., Bhoi, Bibhuti, Trivedi, Chitrang, Rath, Akshyaya, Rathod, Rohan, Ranvir, Ramchandra, Kadam, Shekhar, Patel, Hiren, Swain, Prabodha, Roy, Sib Sankar, Das, Nabanita, Karmakar, Eshani, Wahli, Walter, Patel, Pankaj R.
Publicado 2017

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral NLRP3 Inflammasome Inhibitor ZYIL1: First‐in‐Human Phase 1 Studies (Single Ascending Dose and Multiple Asce...

por Parmar, Deven V., Kansagra, Kevinkumar A., Momin, Taufik, Patel, Hardik B., Jansari, Gaurav A., Bhavsar, Jay, Shah, Chintan, Patel, Jayesh M., Ghoghari, Ashok, Barot, Ajay, Sharma, Bhavesh, Viswanathan, Kasinath, Patel, Harilal V., Jain, Mukul R.
Publicado 2022

Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volu...

por Kansagra, Kevinkumar A., Parmar, Deven, Jani, Rajendra H., Srinivas, Nuggehally R., Lickliter, Jason, Patel, Harilal V., Parikh, Devang P., Heading, Heather, Patel, Hardik B., Gupta, Rahul J., Shah, Chintan Y., Patel, Maulik R., Dholakia, Vyom N., Sukhadiya, Raghav, Jain, Mukul R., Parmar, Krupi V., Barot, Kinjal
Publicado 2017