Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome

por Griffin, Aliesha L, Jaishankar, Priyadarshini, Grandjean, Jean-Marc, Olson, Steven H, Renslo, Adam R, Baraban, Scott C
Publicado 2019

Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases

por Gable, Jonathan E., Lee, Gregory M., Jaishankar, Priyadarshini, Hearn, Brian R., Waddling, Christopher A., Renslo, Adam R., Craik, Charles S.
Publicado 2014

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

por Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.
Publicado 2023

Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6

por Van Horn, Kurt S., Wang, Dongju, Medina-Cleghorn, Daniel, Lee, Peter S., Bryant, Clifford, Altobelli, Chad, Jaishankar, Priyadarshini, Leung, Kevin K., Ng, Raymond A., Ambrose, Andrew J., Tang, Yinyan, Arkin, Michelle R., Renslo, Adam R.
Publicado 2023

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

por Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Publicado 2016

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

por Sidrauski, Carmela, Tsai, Jordan C, Kampmann, Martin, Hearn, Brian R, Vedantham, Punitha, Jaishankar, Priyadarshini, Sokabe, Masaaki, Mendez, Aaron S, Newton, Billy W, Tang, Edward L, Verschueren, Erik, Johnson, Jeffrey R, Krogan, Nevan J, Fraser, Christopher S, Weissman, Jonathan S, Renslo, Adam R, Walter, Peter
Publicado 2015

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

por Heise, Christopher E., Murray, Jeremy, Augustyn, Katherine E., Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M., Gibbons, Paul, Hannoush, Rami N., Hearn, Brian R., Jaishankar, Priyadarshini, Ly, Cuong Q., Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W., Renslo, Adam R., Flygare, John, Arkin, Michelle R.
Publicado 2012