Evaluation and optimisation of unnatural amino acid incorporation and bioorthogonal bioconjugation for site-specific fluorescent labelling of proteins expressed in mammalian cells

por Jakob, Leonhard, Gust, Alexander, Grohmann, Dina
Publicado 2018

Decoupling the bridge helix of Cas12a results in a reduced trimming activity, increased mismatch sensitivity and impaired conformational transitions

por Wörle, Elisabeth, Jakob, Leonhard, Schmidbauer, Andreas, Zinner, Gabriel, Grohmann, Dina
Publicado 2021

Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2

por Willkomm, Sarah, Jakob, Leonhard, Kramm, Kevin, Graus, Veronika, Neumeier, Julia, Meister, Gunter, Grohmann, Dina
Publicado 2022

Probing the stability of the SpCas9–DNA complex after cleavage

por Aldag, Pierre, Welzel, Fabian, Jakob, Leonhard, Schmidbauer, Andreas, Rutkauskas, Marius, Fettes, Fergus, Grohmann, Dina, Seidel, Ralf
Publicado 2021

Structural and functional insights into the fly microRNA biogenesis factor Loquacious

por Jakob, Leonhard, Treiber, Thomas, Treiber, Nora, Gust, Alexander, Kramm, Kevin, Hansen, Kerrin, Stotz, Mathias, Wankerl, Ludwig, Herzog, Franz, Hannus, Stefan, Grohmann, Dina, Meister, Gunter
Publicado 2016

Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins

por Heyam, Alex, Coupland, Claire E., Dégut, Clément, Haley, Ruth A., Baxter, Nicola J., Jakob, Leonhard, Aguiar, Pedro M., Meister, Gunter, Williamson, Michael P., Lagos, Dimitris, Plevin, Michael J.
Publicado 2017