ImmTACs: Novel bi-specific agents for targeted cancer therapy

por Oates, Joanne, Jakobsen, Bent K.
Publicado 2013

Process improvement and comparability analysis for engineered T cell manufacture

por Melchiori, Luca, Kreutz, Martin, Williams, Daniel, Binder-Scholl, Gwendolyn, Kan, On, Moss, David, Jakobsen, Bent
Publicado 2014

Deep phenotypic characterization of NY-ESO TCR engineered T cells and tumor in patients with advanced myeloma

por Davila, Eduardo, Melchiori, Luca, Wong, Ryan, Binder-Scholl, Gwendolyn, Amado, Rafael, Jakobsen, Bent, Rapoport, Aaron
Publicado 2015

Polyfunctional response by ImmTAC (IMCgp100) redirected CD8(+) and CD4(+) T cells

por Boudousquie, Caroline, Bossi, Giovanna, Hurst, Jacob M., Rygiel, Karolina A., Jakobsen, Bent K., Hassan, Namir J.
Publicado 2017

Examining the presentation of tumor-associated antigens on peptide-pulsed T2 cells

por Bossi, Giovanna, Gerry, Andrew B, Paston, Samantha J, Sutton, Deborah H, Hassan, Namir J, Jakobsen, Bent K
Publicado 2013

Improved affinity AFP-specific T cell receptor for hepatocellular carcinoma

por Gerry, Andrew B, Pumphrey, Nicholas J, Docta, Roslin Y, Brewer, Joanna E, Bennett, Alan D, Jakobsen, Bent K
Publicado 2013

The Tumor Targeted Superantigen ABR-217620 Selectively Engages TRBV7-9 and Exploits TCR-pMHC Affinity Mimicry in Mediating T Cell Cytotoxicity

por Hedlund, Gunnar, Eriksson, Helena, Sundstedt, Anette, Forsberg, Göran, Jakobsen, Bent K., Pumphrey, Nicholas, Rödström, Karin, Lindkvist-Petersson, Karin, Björk, Per
Publicado 2013

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

por Pace, Matthew, Williams, James, Kurioka, Ayako, Gerry, Andrew B., Jakobsen, Bent, Klenerman, Paul, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Frater, John
Publicado 2016

Innate-Like Control of Human iNKT Cell Autoreactivity via the Hypervariable CDR3β Loop

por Matulis, Gediminas, Sanderson, Joseph P., Lissin, Nikolai M., Asparuhova, Maria B., Bommineni, Gopal R., Schümperli, Daniel, Schmidt, Richard R., Villiger, Peter M., Jakobsen, Bent K., Gadola, Stephan D.
Publicado 2010

Preclinical safety testing of an affinity-optimised MAGE-A10 T cell receptor for adoptive T cell therapy

por Gerry, Andrew, Sanderson, Joseph, Saini, Manoj, Tavano, Barbara, Docta, Roslin, Pumphrey, Nicholas, Maroto, Miguel, Border, Ellen, Bennett, Alan, Binder-Scholl, Gwendolyn, Holdich, Tom, Pandite, Lini, Amado, Rafael, Jakobsen, Bent
Publicado 2015

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode

por Cole, David K., Sami, Malkit, Scott, Daniel R., Rizkallah, Pierre J., Borbulevych, Oleg Y., Todorov, Penio T., Moysey, Ruth K., Jakobsen, Bent K., Boulter, Jonathan M., Baker, Brian M., Yi Li
Publicado 2013

ImmTACs: bi-specific TCR-anti-CD3 fusions for targeted tumour killing

por Donnellan, Zoe, Bossi, Giovanna, Harper, Jane, Dukes, Joseph, Liddy, Nathaniel, Paston, Samantha, Mahon, Tara, Molloy, Peter, Sami, Malkit, Baston, Emma, Cameron, Brian, Johnson, Andrew, Vuidepot, Annelise, Hassan, Namir, Jakobsen, Bent
Publicado 2015

Structure and binding kinetics of three different human CD1d–α-galactosylceramide–specific T cell receptors

por Gadola, Stephan D., Koch, Michael, Marles-Wright, Jon, Lissin, Nikolai M., Shepherd, Dawn, Matulis, Gediminas, Harlos, Karl, Villiger, Peter M., Stuart, David I., Jakobsen, Bent K., Cerundolo, Vincenzo, Jones, E. Yvonne
Publicado 2006

Optimizing engineered TCR T cell therapy for synovial sarcoma

por D'Angelo, Sandra, Merchant, Melinda, Melchiori, Luca, Zhang, Hua, Pandite, Lini, Holdich, Tom, Binder-Scholl, Gwendolyn, Tap, William, Fortin, Marylene, Peretz, Yoav, Wright, Matthew, Meyers, Paul, Amado, Rafael, Jakobsen, Bent, Mackall, Crystal
Publicado 2015

Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

por Reid, Scott W., McAdam, Steve, Smith, Kathrine J., Klenerman, Paul, O'Callaghan, Chris A., Harlos, Karl, Jakobsen, Bent K., McMichael, Andrew J., Bell, John I., Stuart, David I., Jones, E. Yvonne
Publicado 1996

Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors

por Yang, Hongbing, Buisson, Sandrine, Bossi, Giovanna, Wallace, Zoë, Hancock, Gemma, So, Chun, Ashfield, Rebecca, Vuidepot, Annelise, Mahon, Tara, Molloy, Peter, Oates, Joanne, Paston, Samantha J, Aleksic, Milos, Hassan, Namir J, Jakobsen, Bent K, Dorrell, Lucy
Publicado 2016

Cancer-specific T cell receptor isolation for cancer immunotherapy

por Baker, Debbie Emma, Hibbert, Linda, Weigand, Luise, Paston, Samantha, Ryan, Ruth, Donnellan, Zoe, Simmons, Ruth, Hale, Kathy, Conlon, Louise, Dukes, Joseph, Clark, Vanessa, Boudousquie, Caroline, Bossi, Giovanna, Hickman, Emma, Powlesland, Alex, Vuidepot, Annelise, Hassan, Namir, Jakobsen, Bent
Publicado 2015

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

por Raman, Marine C C, Rizkallah, Pierre J, Simmons, Ruth, Donnellan, Zoe, Dukes, Joseph, Bossi, Giovanna, Le Provost, Gabrielle S, Todorov, Penio, Baston, Emma, Hickman, Emma, Mahon, Tara, Hassan, Namir, Vuidepot, Annelise, Sami, Malkit, Cole, David K, Jakobsen, Bent K.
Publicado 2016

T-cell Receptor Specificity Maintained by Altered Thermodynamics

por Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J. A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., Cole, David K.
Publicado 2013

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

por Cole, David K., Miles, Kim M., Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew J., Bulek, Anna M., Fuller, Anna, Akpovwa, Hephzibah J. E., Pymm, Phillip G., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Rizkallah, Pierre J., Jakobsen, Bent K., Sewell, Andrew K.
Publicado 2014