Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

por Afroz, Tariq, Hock, Eva-Maria, Ernst, Patrick, Foglieni, Chiara, Jambeau, Melanie, Gilhespy, Larissa A. B., Laferriere, Florent, Maniecka, Zuzanna, Plückthun, Andreas, Mittl, Peer, Paganetti, Paolo, Allain, Frédéric H. T., Polymenidou, Magdalini
Publicado 2017

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts

por Tabet, Ricardos, Schaeffer, Laure, Freyermuth, Fernande, Jambeau, Melanie, Workman, Michael, Lee, Chao-Zong, Lin, Chun-Chia, Jiang, Jie, Jansen-West, Karen, Abou-Hamdan, Hussein, Désaubry, Laurent, Gendron, Tania, Petrucelli, Leonard, Martin, Franck, Lagier-Tourenne, Clotilde
Publicado 2018

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

por Scekic‐Zahirovic, Jelena, Sendscheid, Oliver, El Oussini, Hajer, Jambeau, Mélanie, Sun, Ying, Mersmann, Sina, Wagner, Marina, Dieterlé, Stéphane, Sinniger, Jérome, Dirrig‐Grosch, Sylvie, Drenner, Kevin, Birling, Marie‐Christine, Qiu, Jinsong, Zhou, Yu, Li, Hairi, Fu, Xiang‐Dong, Rouaux, Caroline, Shelkovnikova, Tatyana, Witting, Anke, Ludolph, Albert C, Kiefer, Friedemann, Storkebaum, Erik, Lagier‐Tourenne, Clotilde, Dupuis, Luc
Publicado 2016

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

por López-Erauskin, Jone, Tadokoro, Takahiro, Baughn, Michael W., Myers, Brian, McAlonis-Downes, Melissa, Chillon-Marinas, Carlos, Asiaban, Joshua N., Artates, Jonathan, Bui, Anh T., Vetto, Anne P., Lee, Sandra K., Le, Ai Vy, Sun, Ying, Jambeau, Mélanie, Boubaker, Jihane, Swing, Deborah, Qiu, Jinsong, Hicks, Geoffrey G., Ouyang, Zhengyu, Fu, Xiang-Dong, Tessarollo, Lino, Ling, Shuo-Chien, Parone, Philippe A., Shaw, Christopher E., Marsala, Martin, Lagier-Tourenne, Clotilde, Cleveland, Don W., Da Cruz, Sandrine
Publicado 2018

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

por López-Erauskin, Jone, Tadokoro, Takahiro, Baughn, Michael W., Myers, Brian, McAlonis-Downes, Melissa, Chillon-Marinas, Carlos, Asiaban, Joshua N., Artates, Jonathan, Bui, Anh T., Vetto, Anne P., Lee, Sandra K., Le, Ai Vy, Sun, Ying, Jambeau, Mélanie, Boubaker, Jihane, Swing, Deborah, Qiu, Jinsong, Hicks, Geoffrey G., Ouyang, Zhengyu, Fu, Xiang-Dong, Tessarollo, Lino, Ling, Shuo-Chien, Parone, Philippe A., Shaw, Christopher E., Marsala, Martin, Lagier-Tourenne, Clotilde, Cleveland, Don W., Da Cruz, Sandrine
Publicado 2020

Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease

por Jambeau, Melanie, Meyer, Kevin D., Hruska-Plochan, Marian, Tabet, Ricardos, Lee, Chao-Zong, Ray-Soni, Ananya, Aguilar, Corey, Savage, Kitty, Mishra, Nibha, Cavegn, Nicole, Borter, Petra, Lin, Chun-Chia, Jansen-West, Karen R., Jiang, Jie, Freyermuth, Fernande, Li, Nan, De Rossi, Pierre, Pérez-Berlanga, Manuela, Jiang, Xin, Daughrity, Lilian M., Pereira, João, Narayanan, Sarav, Gu, Yuanzheng, Dhokai, Shekhar, Dalkilic-Liddle, Isin, Maniecka, Zuzanna, Weber, Julien, Workman, Michael, McAlonis-Downes, Melissa, Berezovski, Eugene, Zhang, Yong-Jie, Berry, James, Wainger, Brian J., Kankel, Mark W., Rushe, Mia, Hock, Christoph, Nitsch, Roger M., Cleveland, Don W., Petrucelli, Leonard, Gendron, Tania F., Montrasio, Fabio, Grimm, Jan, Polymenidou, Magdalini, Lagier-Tourenne, Clotilde
Publicado 2022