An optimized measles virus glycoprotein-pseudotyped lentiviral vector production system to promote efficient transduction of human primary B cells

por Vamva, Eirini, Ozog, Stosh, Verhoeyen, Els, James, Richard G., Rawlings, David J., Torbett, Bruce E.
Publicado 2022

Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/β-Catenin Signaling

por Robin, Nicholas C., Agoston, Zsuzsa, Biechele, Travis L., James, Richard G., Berndt, Jason D., Moon, Randall T.
Publicado 2013

Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responses

por Wray-Dutra, Michelle N., Al Qureshah, Fahd, Metzler, Genita, Oukka, Mohamed, James, Richard G., Rawlings, David J.
Publicado 2018

Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing

por Hill, Tyler F., Narvekar, Parnal, Asher, Gregory, Camp, Nathan, Thomas, Kerri R., Tasian, Sarah K., Rawlings, David J., James, Richard G.
Publicado 2023

Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress

por Al Qureshah, Fahd, Sagadiev, Sara, Thouvenel, Christopher D., Liu, Shuozhi, Hua, Zhaolin, Hou, Baidong, Acharya, Mridu, James, Richard G., Rawlings, David J.
Publicado 2021

Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein

por Camp, Nathan D., James, Richard G., Dawson, David W., Yan, Feng, Davison, James M., Houck, Scott A., Tang, Xiaobo, Zheng, Ning, Major, Michael B., Moon, Randall T.
Publicado 2012

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells

por Hung, King L., Meitlis, Iana, Hale, Malika, Chen, Chun-Yu, Singh, Swati, Jackson, Shaun W., Miao, Carol H., Khan, Iram F., Rawlings, David J., James, Richard G.
Publicado 2018

Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation

por Wray-Dutra, Michelle N., Chawla, Raghav, Thomas, Kerri R., Seymour, Brenda J., Arkatkar, Tanvi, Sommer, Karen M., Khim, Socheath, Trapnell, Cole, James, Richard G., Rawlings, David J.
Publicado 2018

WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

por James, Richard G., Davidson, Kathryn C., Bosch, Katherine A., Biechele, Travis L., Robin, Nicholas C., Taylor, Russell J., Major, Michael B., Camp, Nathan D., Fowler, Kerry, Martins, Timothy J., Moon, Randall T.
Publicado 2012

Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation

por Gelman, Hannah, Dines, Jennifer N., Berg, Jonathan, Berger, Alice H., Brnich, Sarah, Hisama, Fuki M., James, Richard G., Rubin, Alan F., Shendure, Jay, Shirts, Brian, Fowler, Douglas M., Starita, Lea M.
Publicado 2019

SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells

por Cheng, Rene Yu-Hong, de Rutte, Joseph, Ito, Cade Ellis K., Ott, Andee R., Bosler, Lucie, Kuo, Wei-Ying, Liang, Jesse, Hall, Brian E., Rawlings, David J., Di Carlo, Dino, James, Richard G.
Publicado 2023

Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo

por Cheng, Rene Yu-Hong, Hung, King L., Zhang, Tingting, Stoffers, Claire M., Ott, Andee R., Suchland, Emmaline R., Camp, Nathan D., Khan, Iram F., Singh, Swati, Yang, Ying-Jen, Rawlings, David J., James, Richard G.
Publicado 2022

Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells

por James, Richard G., Bosch, Katherine A., Kulikauskas, Rima M., Yang, Peitzu T., Robin, Nick C., Toroni, Rachel A., Biechele, Travis L., Berndt, Jason D., von Haller, Priska D., Eng, Jimmy K., Wolf-Yadlin, Alejandro, Chien, Andy J., Moon, Randall T.
Publicado 2013

Transcriptomic analysis of pathways associated with ITGAV/alpha(v) integrin-dependent autophagy in human B cells

por Muir, Virginia, Sagadiev, Sara, Liu, Shuozhi, Holder, Ursula, Armendariz, Andrea M., Suchland, Emmaline, Meitlis, Iana, Camp, Nathan, Giltiay, Natalia, Tam, Jenny M., Garner, Ethan C., Wivagg, Carl N., Shows, Donna, James, Richard G., Lacy-Hulbert, Adam, Acharya, Mridu
Publicado 2022

A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-knob-in-hole-reversed immunoadhesin

por Vamva, Eirini, Ozog, Stosh, Leaman, Daniel P., Yu-Hong Cheng, Rene, Irons, Nicholas J., Ott, Andee, Stoffers, Claire, Khan, Iram, Goebrecht, Geraldine K.E., Gardner, Matthew R., Farzan, Michael, Rawlings, David J., Zwick, Michael B., James, Richard G., Torbett, Bruce E.
Publicado 2023

The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity

por Gorman, Jacquelyn A., Hundhausen, Christian, Errett, John S., Stone, Amy E., Allenspach, Eric J., Ge, Yan, Arkatkar, Tanvi, Clough, Courtnee, Dai, Xuezhi, Khim, Socheath, Pestal, Kathleen, Liggitt, Denny, Cerosaletti, Karen, Stetson, Daniel B., James, Richard G., Oukka, Mohamed, Concannon, Patrick, Gale, Michael, Buckner, Jane H., Rawlings, David J.
Publicado 2017

Multiplexed Functional Assessment of Genetic Variants in CARD11

por Meitlis, Iana, Allenspach, Eric J., Bauman, Bradly M., Phan, Isabelle Q., Dabbah, Gina, Schmitt, Erica G., Camp, Nathan D., Torgerson, Troy R., Nickerson, Deborah A., Bamshad, Michael J., Hagin, David, Luthers, Christopher R., Stinson, Jeffrey R., Gray, Jessica, Lundgren, Ingrid, Church, Joseph A., Butte, Manish J., Jordan, Mike B., Aceves, Seema S., Schwartz, Daniella M., Milner, Joshua D., Schuval, Susan, Skoda-Smith, Suzanne, Cooper, Megan A., Starita, Lea M., Rawlings, David J., Snow, Andrew L., James, Richard G.
Publicado 2020