Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks

por Lebozec, Kristell, Jandrot-Perrus, Martine, Avenard, Gilles, Favre-Bulle, Olivier, Billiald, Philippe
Publicado 2017

Glycoprotein VI in securing vascular integrity in inflamed vessels

por Boulaftali, Yacine, Mawhin, Marie‐Anne, Jandrot‐Perrus, Martine, Ho‐Tin‐Noé, Benoît
Publicado 2018

Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan

por Jiang, Peng, Loyau, Stéphane, Tchitchinadze, Maria, Ropers, Jacques, Jondeau, Guillaume, Jandrot-Perrus, Martine
Publicado 2015

Collagen Can Selectively Trigger a Platelet Secretory Phenotype via Glycoprotein VI

por Ollivier, Véronique, Syvannarath, Varouna, Gros, Angèle, Butt, Amena, Loyau, Stéphane, Jandrot-Perrus, Martine, Ho-Tin-Noé, Benoît
Publicado 2014

Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation

por Renaud, Lionel, Lebozec, Kristell, Voors‐Pette, Christine, Dogterom, Peter, Billiald, Philippe, Jandrot Perrus, Martine, Pletan, Yannick, Machacek, Matthias
Publicado 2020

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability

por Ahmed, Muhammad Usman, Receveur, Nicolas, Janus‐Bell, Emily, Mouriaux, Clarisse, Gachet, Christian, Jandrot‐Perrus, Martine, Hechler, Béatrice, Gardiner, Elizabeth E., Mangin, Pierre H.
Publicado 2021

Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion

por Desilles, Jean‐Philippe, Syvannarath, Varouna, Di Meglio, Lucas, Ducroux, Célina, Boisseau, William, Louedec, Liliane, Jandrot‐Perrus, Martine, Michel, Jean‐Baptiste, Mazighi, Mikael, Ho‐Tin‐Noé, Benoît
Publicado 2018

Interferon Alpha Therapy Increases Pro-Thrombotic Biomarkers in Patients with Myeloproliferative Neoplasms

por Faille, Dorothée, Lamrani, Lamia, Loyau, Stéphane, Huisse, Marie-Geneviève, Bourrienne, Marie-Charlotte, Alkhaier, Sawsaneh, Cassinat, Bruno, Boulaftali, Yacine, Debus, Jérôme, Jandrot-Perrus, Martine, Chomienne, Christine, Dosquet, Christine, Ajzenberg, Nadine
Publicado 2020

Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition

por Billiald, Philippe, Slater, Alexandre, Welin, Martin, Clark, Joanne C., Loyau, Stéphane, Pugnière, Martine, Jiacomini, Isabella G., Rose, Nadia, Lebozec, Kristell, Toledano, Elie, François, Déborah, Watson, Steve P., Jandrot-Perrus, Martine
Publicado 2022

Non-Invasive Molecular Imaging of Fibrosis Using a Collagen-Targeted Peptidomimetic of the Platelet Collagen Receptor Glycoprotein VI

por Muzard, Julien, Sarda-Mantel, Laure, Loyau, Stéphane, Meulemans, Alain, Louedec, Liliane, Bantsimba-Malanda, Claudie, Hervatin, Florence, Marchal-Somme, Joëlle, Michel, Jean Baptiste, Le Guludec, Dominique, Billiald, Philippe, Jandrot-Perrus, Martine
Publicado 2009

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1

por De Simone, Ilaria, Baaten, Constance C. F. M. J., Jandrot-Perrus, Martine, Gibbins, Jonathan M., ten Cate, Hugo, Heemskerk, Johan W. M., Jones, Chris I., van der Meijden, Paola E. J.
Publicado 2022

In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent

por Delattre, Cécilia, Velazquez, Diego, Roques, Caroline, Pavon-Djavid, Graciela, Ollivier, Véronique, Lokajczyk, Anna, Avramoglou, Thierry, Gueguen, Virginie, Louedec, Liliane, Caligiuri, Giuseppina, Jandrot-Perrus, Martine, Boisson-Vidal, Catherine, Letourneur, Didier, Meddahi-Pelle, Anne
Publicado 2019

Vascular endothelial cell expression of JAK2(V617F) is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

por Guy, Alexandre, Gourdou-Latyszenok, Virginie, Le Lay, Nicolas, Peghaire, Claire, Kilani, Badr, Dias, Juliana Vieira, Duplaa, Cécile, Renault, Marie-Ange, Denis, Cécile, Villeval, Jean Luc, Boulaftali, Yacine, Jandrot-Perrus, Martine, Couffinhal, Thierry, James, Chloe
Publicado 2019

Glenzocimab does not impact glycoprotein VI-dependent inflammatory hemostasis

por Jadoui, Soumaya, Le Chapelain, Ophélie, Ollivier, Véronique, Mostefa-Kara, Ali, Di Meglio, Lucas, Dupont, Sébastien, Gros, Angèle, Nomenjanahary, Mialitiana Solo, Desilles, Jean-Philippe, Mazighi, Mikaël, Nieswandt, Bernhard, Loyau, Stéphane, Jandrot-Perrus, Martine, Mangin, Pierre H., Ho-Tin-Noé, Benoit
Publicado 2020

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

por Flierl, Ulrike, Nero, Tracy L., Lim, Bock, Arthur, Jane F., Yao, Yu, Jung, Stephanie M., Gitz, Eelo, Pollitt, Alice Y., Zaldivia, Maria T.K., Jandrot-Perrus, Martine, Schäfer, Andreas, Nieswandt, Bernhard, Andrews, Robert K., Parker, Michael W., Gardiner, Elizabeth E., Peter, Karlheinz
Publicado 2015

Immobilized fibrinogen activates human platelets through glycoprotein VI

por Mangin, Pierre H, Onselaer, Marie-Blanche, Receveur, Nicolas, Le Lay, Nicolas, Hardy, Alexander T, Wilson, Clare, Sanchez, Ximena, Loyau, Stéphane, Dupuis, Arnaud, Babar, Amir K, Miller, Jeanette LC, Philippou, Helen, Hughes, Craig E, Herr, Andrew B, Ariëns, Robert AS, Mezzano, Diego, Jandrot-Perrus, Martine, Gachet, Christian, Watson, Steve P.
Publicado 2018

Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an inter...

por Riegger, Julia, Byrne, Robert A., Joner, Michael, Chandraratne, Sue, Gershlick, Anthony H., ten Berg, Jurrien M., Adriaenssens, Tom, Guagliumi, Giulio, Godschalk, Thea C., Neumann, Franz-Josef, Trenk, Dietmar, Feldman, Laurent J., Steg, Philippe Gabriel, Desmet, Walter, Alfonso, Fernando, Goodall, Alison H., Wojdyla, Roman, Dudek, Dariusz, Philippi, Vanessa, Opinaldo, Sheryl, Titova, Anna, Malik, Nikesh, Cotton, James, Jhagroe, Darshni A., Heestermans, Antonius A.C.M., Sinnaeve, Peter, Vermeersch, Paul, Valina, Christian, Schulz, Christian, Kastrati, Adnan, Massberg, Steffen, Adriaenssens, Tom, Buysschaert, Ian, Chausson, Mickaël, De Cock, Dries, Dens, Jo, Barbato, Emanuele, Desmet, Walter, Gautier, Sandrine, Vermeersch, Paul, Sinnaeve, Peter, Abergel, Helene, Feldman, Laurent, Jandrot-Perrus, Martine, Letourneur, Didier, Mangin, Pierre, Olivier, Véronique, Roques, Caroline, Byrne, Robert A., Chandraratne, Sue, Gratz, Matthias, Joner, Michael, Kastrati, Adnan, Kennerknecht, Elisabeth, Konrad, Ildiko, Koppara, Tobias, Massberg, Steffen, Neumann, Franz-Josef, Ntziachristos, Vasilis, Opinaldo, Sheryl, Philippi, Vanessa, Riegger, Julia, Rosenthal, Amir, Rzany, Alexander, Schulz, Christian, Steigerwald, Kristin, Tada, Tomohiso, Titova, Anna, Trenk, Dietmar, Valina, Christian, Vogelsang, Andreas, Xhepa, Erion, Bernelli, Chiara, Coccato, Micol, Guagliumi, Giulio, Komukai, Kenichi, Sirbu, Vasile, Kerch, Garry, Amoroso, Giovanni, ten Berg, Jurriën, Dewilde, Willem J.M., Godschalk, Thea C., Heestermans, Antonius A.C.M., Jhagroe, Darshni A., Wykrzykowska, Joanne J., Winkens, Mark H.M., Dudek, Dariusz, Rzeszutko, Łukasz, Wojdyla, Roman, Zasada, Wojciech, Alfonso, Fernando, Cuesta, Javier, Medina, Miguel, Berry, Colin, Cotton, James, Curzen, Nick, McEntegart, Margaret, Gerber, Robert, Gershlick, Anthony, Goodall, Alison H., Hetherington, Simon, Hill, Jonathan, Kelly, Damian, Malik, Nikesh, Oldroyd, Keith, Routledge, Helen, Shannon, Joanne, Suresh, Venkatesan, Zahman, Azfar
Publicado 2016