Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models

por Lim, Melina J., Boschen, Suelen L., Kurti, Aishe, Castanedes Casey, Monica, Phillips, Virginia R., Fryer, John D., Dickson, Dennis, Jansen-West, Karen R., Petrucelli, Leonard, Delenclos, Marion, McLean, Pamela J.
Publicado 2023

Astrocyte-derived clusterin suppresses amyloid formation in vivo

por Wojtas, Aleksandra M., Sens, Jonathon P., Kang, Silvia S., Baker, Kelsey E., Berry, Taylor J., Kurti, Aishe, Daughrity, Lillian, Jansen-West, Karen R., Dickson, Dennis W., Petrucelli, Leonard, Bu, Guojun, Liu, Chia-Chen, Fryer, John D.
Publicado 2020

Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila

por De Mena, Lorena, Smith, Michael A., Martin, Jason, Dunton, Katie L., Ceballos-Diaz, Carolina, Jansen-West, Karen R., Cruz, Pedro E., Dillon, Kristy D., Rincon-Limas, Diego E., Golde, Todd E., Moore, Brenda D., Levites, Yona
Publicado 2020

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency

por Lee, Wing C., Almeida, Sandra, Prudencio, Mercedes, Caulfield, Thomas R., Zhang, Yong-Jie, Tay, William M., Bauer, Peter O., Chew, Jeannie, Sasaguri, Hiroki, Jansen-West, Karen R., Gendron, Tania F., Stetler, Caroline T., Finch, NiCole, Mackenzie, Ian R., Rademakers, Rosa, Gao, Fen-Biao, Petrucelli, Leonard
Publicado 2014

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency

por Frew, Jonathan, Baradaran-Heravi, Alireza, Balgi, Aruna D., Wu, Xiujuan, Yan, Tyler D., Arns, Steve, Shidmoossavee, Fahimeh S., Tan, Jason, Jaquith, James B., Jansen-West, Karen R., Lynn, Francis C., Gao, Fen-Biao, Petrucelli, Leonard, Feldman, Howard H., Mackenzie, Ian R., Roberge, Michel, Nygaard, Haakon B.
Publicado 2020

Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation

por Wojtas, Aleksandra M., Carlomagno, Yari, Sens, Jonathon P., Kang, Silvia S., Jensen, Tanner D., Kurti, Aishe, Baker, Kelsey E., Berry, Taylor J., Phillips, Virginia R., Castanedes, Monica Casey, Awan, Ayesha, DeTure, Michael, De Castro, Cristhoper H. Fernandez, Librero, Ariston L., Yue, Mei, Daughrity, Lillian, Jansen-West, Karen R., Cook, Casey N., Dickson, Dennis W., Petrucelli, Leonard, Fryer, John D.
Publicado 2020

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

por Nicholson, Alexandra M., Zhou, Xiaolai, Perkerson, Ralph B., Parsons, Tammee M., Chew, Jeannie, Brooks, Mieu, DeJesus-Hernandez, Mariely, Finch, NiCole A., Matchett, Billie J., Kurti, Aishe, Jansen-West, Karen R., Perkerson, Emilie, Daughrity, Lillian, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Hu, Fenghua, Gendron, Tania F., Murray, Melissa E., Dickson, Dennis W., Fryer, John D., Petrucelli, Leonard, Rademakers, Rosa
Publicado 2018

Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

por Prudencio, Mercedes, Erben, Young, Marquez, Christopher P., Jansen-West, Karen R., Franco-Mesa, Camila, Heckman, Michael G., White, Launia J., Dunmore, Judith A., Cook, Casey N., Lilley, Meredith T., Song, Yuping, Harlow, Caroline F., Oskarsson, Björn, Nicholson, Katharine A., Wszolek, Zbigniew K., Hickson, LaTonya J., O’Horo, John C., Hoyne, Jonathan B., Gendron, Tania F., Meschia, James F., Petrucelli, Leonard
Publicado 2021

Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19

por Erben, Young, Prudencio, Mercedes, Marquez, Christopher P., Jansen-West, Karen R., Heckman, Michael G., White, Launia J., Dunmore, Judith A., Cook, Casey N., Lilley, Meredith T., Qosja, Neda, Song, Yuping, Hanna Al Shaikh, Rana, Daughrity, Lillian M., Bartfield, Jordan L., Day, Gregory S., Oskarsson, Björn, Nicholson, Katharine A., Wszolek, Zbigniew K., Hoyne, Jonathan B., Gendron, Tania F., Meschia, James F., Petrucelli, Leonard
Publicado 2022

Tau and neurofilament light‐chain as fluid biomarkers in spinocerebellar ataxia type 3

por Garcia‐Moreno, Hector, Prudencio, Mercedes, Thomas‐Black, Gilbert, Solanky, Nita, Jansen‐West, Karen R., Hanna AL‐Shaikh, Rana, Heslegrave, Amanda, Zetterberg, Henrik, Santana, Magda M., Pereira de Almeida, Luis, Vasconcelos‐Ferreira, Ana, Januário, Cristina, Infante, Jon, Faber, Jennifer, Klockgether, Thomas, Reetz, Kathrin, Raposo, Mafalda, Ferreira, Ana F., Lima, Manuela, Schöls, Ludger, Synofzik, Matthis, Hübener‐Schmid, Jeannette, Puschmann, Andreas, Gorcenco, Sorina, Wszolek, Zbigniew K., Petrucelli, Leonard, Giunti, Paola
Publicado 2022

Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3

por Koike, Yuka, Jansen-West, Karen R., AL-Shaikh, Rana Hanna, Carlomagno, Yari, Song, Yuping, Dunmore, Judith A., LeDoux, Mark S., Friedman, Joseph H., Pena, Ashley B., Uitti, Ryan J., Zaremba, Jacek, van Gerpen, Jay A., Pfeiffer, Ronald F., Veerappan, Venka, Aiba, Ikuko, Hashimoto, Rina, Giles, Samuel S., Shah, Jaimin S., Tipton, Philip W., Huang, Josephine F., Wierenga, Klaas J., Aasly, Jan, Fryer, John D., Petrucelli, Leonard, Wszolek, Zbigniew K., Prudencio, Mercedes
Publicado 2021

Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers

por Finch, NiCole A., Wang, Xue, Baker, Matthew C., Heckman, Michael G., Gendron, Tania F., Bieniek, Kevin F., Wuu, Joanne, DeJesus-Hernandez, Mariely, Brown, Patricia H., Chew, Jeannie, Jansen-West, Karen R., Daughrity, Lillian M., Nicholson, Alexandra M., Murray, Melissa E., Josephs, Keith A., Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Petrucelli, Leonard, Boeve, Bradley F., Graff-Radford, Neill R., Asmann, Yan W., Dickson, Dennis W., Benatar, Michael, Bowser, Robert, Boylan, Kevin B., Rademakers, Rosa, van Blitterswijk, Marka
Publicado 2017

Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease

por Jambeau, Melanie, Meyer, Kevin D., Hruska-Plochan, Marian, Tabet, Ricardos, Lee, Chao-Zong, Ray-Soni, Ananya, Aguilar, Corey, Savage, Kitty, Mishra, Nibha, Cavegn, Nicole, Borter, Petra, Lin, Chun-Chia, Jansen-West, Karen R., Jiang, Jie, Freyermuth, Fernande, Li, Nan, De Rossi, Pierre, Pérez-Berlanga, Manuela, Jiang, Xin, Daughrity, Lilian M., Pereira, João, Narayanan, Sarav, Gu, Yuanzheng, Dhokai, Shekhar, Dalkilic-Liddle, Isin, Maniecka, Zuzanna, Weber, Julien, Workman, Michael, McAlonis-Downes, Melissa, Berezovski, Eugene, Zhang, Yong-Jie, Berry, James, Wainger, Brian J., Kankel, Mark W., Rushe, Mia, Hock, Christoph, Nitsch, Roger M., Cleveland, Don W., Petrucelli, Leonard, Gendron, Tania F., Montrasio, Fabio, Grimm, Jan, Polymenidou, Magdalini, Lagier-Tourenne, Clotilde
Publicado 2022