Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

por Hutti, Jessica E., Porter, Melissa A., Cheely, Adam W., Cantley, Lewis C., Wang, Xiaodong, Kireev, Dmitri, Baldwin, Albert S., Janzen, William P.
Publicado 2012

Cavitation Enhancing Nanodroplets Mediate Efficient DNA Fragmentation in a Bench Top Ultrasonic Water Bath

por Kasoji, Sandeep K., Pattenden, Samantha G., Malc, Ewa P., Jayakody, Chatura N., Tsuruta, James K., Mieczkowski, Piotr A., Janzen, William P., Dayton, Paul A.
Publicado 2015

Filtration Improves the Performance of a High-Throughput Screen for Anti-Mycobacterial Compounds

por Cheng, Nancy, Porter, Melissa A., Frick, Lloyd W., Nguyen, Yvonne, Hayden, Jennifer D., Young, Ellen F., Braunstein, Miriam S., Hull-Ryde, Emily A., Janzen, William P.
Publicado 2014

Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing

por Shen, Min, Asawa, Rosita, Zhang, Ya-Qin, Cunningham, Elizabeth, Sun, Hongmao, Tropsha, Alexander, Janzen, William P., Muratov, Eugene N., Capuzzi, Stephen J., Farag, Sherif, Jadhav, Ajit, Blatt, Julie, Simeonov, Anton, Martinez, Natalia J.
Publicado 2017

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8

por Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M., Herold, J. Martin, Butler, Kyle V., Norris, Jacqueline L., Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Vedadi, Masoud, Brown, Peter J., Jin, Jian
Publicado 2014

Identification of a peptide inhibitor for the histone methyltransferase WHSC1

por Morrison, Michael J., Boriack-Sjodin, P. Ann, Swinger, Kerren K., Wigle, Tim J., Sadalge, Dipti, Kuntz, Kevin W., Scott, Margaret Porter, Janzen, William P., Chesworth, Richard, Duncan, Kenneth W., Harvey, Darren M., Lampe, John W., Mitchell, Lorna H., Copeland, Robert A.
Publicado 2018

UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

por Zhang, Weihe, DeRyckere, Deborah, Hunter, Debra, Liu, Jing, Stashko, Michael A., Minson, Katherine A., Cummings, Christopher T., Lee, Minjung, Glaros, Trevor G., Newton, Dianne L., Sather, Susan, Zhang, Dehui, Kireev, Dmitri, Janzen, William P., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado 2014

Expression of Ror2 Mediates Invasive Phenotypes in Renal Cell Carcinoma

por Rasmussen, Neal R., Debebe, Zufan, Wright, Tricia M., Brooks, Samira A., Sendor, Adam B., Brannon, A . Rose, Hakimi, A . Ari, Hsieh, James J., Choueiri, Toni K., Tamboli, Pheroze, Maranchie, Jodi K., Hinds, Peter, Wallen, Eric M., Simpson, Catherine, Norris, Jacqueline L., Janzen, William P., Rathmell, W. Kimryn
Publicado 2014

Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain

por James, Lindsey I., Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K., Herold, Martin J., MacNevin, Christopher J., Norris, Jacqueline L., Sagum, Cari A., Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F., Kireev, Dmitri B., Jin, Jian, Janzen, William P., Brown, Peter J., Bedford, Mark T., Arrowsmith, Cheryl H., Frye, Stephen V.
Publicado 2013

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation

por Thomenius, Michael J., Totman, Jennifer, Harvey, Darren, Mitchell, Lorna H., Riera, Thomas V., Cosmopoulos, Kat, Grassian, Alexandra R., Klaus, Christine, Foley, Megan, Admirand, Elizabeth A., Jahic, Haris, Majer, Christina, Wigle, Tim, Jacques, Suzanne L., Gureasko, Jodi, Brach, Dorothy, Lingaraj, Trupti, West, Kip, Smith, Sherri, Rioux, Nathalie, Waters, Nigel J., Tang, Cuyue, Raimondi, Alejandra, Munchhof, Michael, Mills, James E., Ribich, Scott, Porter Scott, Margaret, Kuntz, Kevin W., Janzen, William P., Moyer, Mikel, Smith, Jesse J., Chesworth, Richard, Copeland, Robert A., Boriack-Sjodin, P. Ann
Publicado 2018