Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease

por Jara, Javier H., Genç, Barış, Klessner, Jodi L., Özdinler, P. Hande
Publicado 2014

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms

por Gautam, Mukesh, Jara, Javier H., Sekerkova, Gabriella, Yasvoina, Marina V., Martina, Marco, Özdinler, P. Hande
Publicado 2016

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

por Jara, Javier H., Gautam, Mukesh, Kocak, Nuran, Xie, Edward F., Mao, Qinwen, Bigio, Eileen H., Özdinler, P. Hande
Publicado 2019

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

por Genç, Barış, Jara, Javier H., Sanchez, Santana S., Lagrimas, Amiko K. B., Gozutok, Oge, Kocak, Nuran, Zhu, Yongling, Özdinler, P. Hande
Publicado 2022

Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

por Jara, Javier H., Genç, Barış, Cox, Gregory A., Bohn, Martha C., Roos, Raymond P., Macklis, Jeffrey D., Ulupınar, Emel, Özdinler, P. Hande
Publicado 2015

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

por Jara, Javier H., Sheets, Patrick L., Nigro, Maximiliano José, Perić, Mina, Brooks, Carolyn, Heller, Daniel B., Martina, Marco, Andjus, Pavle R., Ozdinler, P. Hande
Publicado 2020

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

por Genç, Barış, Jara, Javier H., Lagrimas, Amiko K. B., Pytel, Peter, Roos, Raymond P., Mesulam, M. Marsel, Geula, Changiz, Bigio, Eileen H., Özdinler, P. Hande
Publicado 2017

Evidence for an early innate immune response in the motor cortex of ALS

por Jara, Javier H., Genç, Barış, Stanford, Macdonell J., Pytel, Peter, Roos, Raymond P., Weintraub, Sandra, Mesulam, M. Marsel, Bigio, Eileen H., Miller, Richard J., Özdinler, P. Hande
Publicado 2017

Absence of UCHL 1 function leads to selective motor neuropathy

por Genç, Barış, Jara, Javier H., Schultz, Megan C., Manuel, Marin, Stanford, Macdonell J., Gautam, Mukesh, Klessner, Jodi L., Sekerkova, Gabriella, Heller, Daniel B., Cox, Gregory A., Heckman, Charles J., DiDonato, Christine J., Özdinler, P. Hande
Publicado 2016