Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency

por Lee, Eun-Jeong, De Winter, Josine M., Buck, Danielle, Jasper, Jeffrey R., Malik, Fady I., Labeit, Siegfried, Ottenheijm, Coen A., Granzier, Henk
Publicado 2013

Fast Skeletal Muscle Troponin Activator tirasemtiv Increases Muscle Function and Performance in the B6SJL-SOD1(G93A) ALS Mouse Model

por Hwee, Darren T., Kennedy, Adam, Ryans, Julie, Russell, Alan J., Jia, Zhiheng, Hinken, Aaron C., Morgans, David J., Malik, Fady I., Jasper, Jeffrey R.
Publicado 2014

The Ca(2+) sensitizer CK‐2066260 increases myofibrillar Ca(2+) sensitivity and submaximal force selectively in fast skeletal muscle

por Hwee, Darren T., Cheng, Arthur J., Hartman, James J., Hinken, Aaron C., Lee, Ken, Durham, Nickie, Russell, Alan J., Malik, Fady I., Westerblad, Håkan, Jasper, Jeffrey R.
Publicado 2017

Pharmacological properties of revefenacin (TD‐4208), a novel, nebulized long‐acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat,...

por Hegde, Sharath S., Pulido‐Rios, M. Teresa, Luttmann, Mark A., Foley, James J., Hunsberger, Gerald E., Steinfeld, Tod, Lee, TaeWeon, Ji, Yuhua, Mammen, Mathai M., Jasper, Jeffrey R.
Publicado 2018

Fast skeletal muscle troponin activator CK‐2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction

por Cheng, Arthur J., Hwee, Darren T., Kim, Leo H., Durham, Nickie, Yang, Hsiao T., Hinken, Aaron C., Kennedy, Adam R., Terjung, Ronald L., Jasper, Jeffrey R., Malik, Fady I., Westerblad, Håkan
Publicado 2019

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

por de Winter, Josine Marieke, Buck, Danielle, Hidalgo, Carlos, Jasper, Jeffrey R, Malik, Fady I, Clarke, Nigel F, Stienen, Ger J M, Lawlor, Michael W, Beggs, Alan H, Ottenheijm, Coen A C, Granzier, Henk
Publicado 2013