The Genome in a Three-Dimensional Context: Deciphering the Contribution of Noncoding Mutations at Enhancers to Blood Cancer

por Rovirosa, Llorenç, Ramos-Morales, Alberto, Javierre, Biola M.
Publicado 2020

S109: P53 ORCHESTRATES SPATIO-TEMPORAL EPIGENOME REWIRING TO TRANSCRIPTIONALLY PREVENT MALIGNANT TRANSFORMATION

por Serra, François, Cabrera, Monica, Rovirosa, Llorenc, Nieto-Aliseda, Andrea, Fnalo-Escudero, Lucía, Valencia, Alfonso, Javierre, Biola M
Publicado 2023

High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation

por Rico, Daniel, Kent, Daniel, Karataraki, Nefeli, Mikulasova, Aneta, Berlinguer-Palmini, Rolando, Walker, Brian A., Javierre, Biola M., Russell, Lisa J., Brackley, Chris A.
Publicado 2022

B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation

por Bueno-Costa, Alberto, Piñeyro, David, Soler, Marta, Javierre, Biola M., Raurell-Vila, Helena, Subirana-Granés, Marc, Pasquali, Lorenzo, Martinez-Climent, Jose A., Esteller, Manel
Publicado 2019

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci

por Li, Tianlu, Ortiz-Fernández, Lourdes, Andrés-León, Eduardo, Ciudad, Laura, Javierre, Biola M., López-Isac, Elena, Guillén-Del-Castillo, Alfredo, Simeón-Aznar, Carmen Pilar, Ballestar, Esteban, Martin, Javier
Publicado 2020

Genome wide mapping of long range contacts unveils DNA Double Strand Breaks clustering at damaged active genes

por Aymard, François, Aguirrebengoa, Marion, Guillou, Emmanuelle, Javierre, Biola M, Bugler, Beatrix, Arnould, Coline, Rocher, Vincent, Iacovoni, Jason S, Biernacka, Anna, Skrzypczak, Magdalena, Ginalski, Krzysztof, Rowicka, Maga, Fraser, Peter, Legube, Gaëlle
Publicado 2017

Epigenetic alterations in autoimmune disease

por Ballestar, Esteban, Javierre, Biola M, de la Rica, Lorenzo, Gómez-Cabrero, David, Tegnér, Jesper, Gomez-Vaquero, Carmen, Narvaez, Javier, Hernando, Henar, Rodriguez, Virginia C, Vento, Roser, Ciudad, Laura, Rodriguez-Ubreva, Javier
Publicado 2011

IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

por Vento-Tormo, Roser, Company, Carlos, Rodríguez-Ubreva, Javier, de la Rica, Lorenzo, Urquiza, José M., Javierre, Biola M., Sabarinathan, Radhakrishnan, Luque, Ana, Esteller, Manel, Aran, Josep M., Álvarez-Errico, Damiana, Ballestar, Esteban
Publicado 2016

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

por Choy, Mun-Kit, Javierre, Biola M., Williams, Simon G., Baross, Stephanie L., Liu, Yingjuan, Wingett, Steven W., Akbarov, Artur, Wallace, Chris, Freire-Pritchett, Paula, Rugg-Gunn, Peter J., Spivakov, Mikhail, Fraser, Peter, Keavney, Bernard D.
Publicado 2018

Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

por Choy, Mun-Kit, Javierre, Biola M., Williams, Simon G., Baross, Stephanie L., Liu, Yingjuan, Wingett, Steven W., Akbarov, Artur, Wallace, Chris, Freire-Pritchett, Paula, Rugg-Gunn, Peter J., Spivakov, Mikhail, Fraser, Peter, Keavney, Bernard D.
Publicado 2018

Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution

por Tomás-Daza, Laureano, Rovirosa, Llorenç, López-Martí, Paula, Nieto-Aliseda, Andrea, Serra, François, Planas-Riverola, Ainoa, Molina, Oscar, McDonald, Rebecca, Ghevaert, Cedric, Cuatrecasas, Esther, Costa, Dolors, Camós, Mireia, Bueno, Clara, Menéndez, Pablo, Valencia, Alfonso, Javierre, Biola M.
Publicado 2023

The HDAC7–TET2 epigenetic axis is essential during early B lymphocyte development

por Azagra, Alba, Meler, Ainara, de Barrios, Oriol, Tomás-Daza, Laureano, Collazo, Olga, Monterde, Beatriz, Obiols, Mireia, Rovirosa, Llorenç, Vila-Casadesús, Maria, Cabrera-Pasadas, Mónica, Gusi-Vives, Mar, Graf, Thomas, Varela, Ignacio, Sardina, José Luis, Javierre, Biola M, Parra, Maribel
Publicado 2022

Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes

por Mielczarek, Olga, Rogers, Carolyn H., Zhan, Yinxiu, Matheson, Louise S., Stubbington, Michael J.T., Schoenfelder, Stefan, Bolland, Daniel J., Javierre, Biola M., Wingett, Steven W., Várnai, Csilla, Segonds-Pichon, Anne, Conn, Simon J., Krueger, Felix, Andrews, Simon, Fraser, Peter, Giorgetti, Luca, Corcoran, Anne E.
Publicado 2023

The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion

por Hernando, Henar, Shannon-Lowe, Claire, Islam, Abul B, Al-Shahrour, Fatima, Rodríguez-Ubreva, Javier, Rodríguez-Cortez, Virginia C, Javierre, Biola M, Mangas, Cristina, Fernández, Agustín F, Parra, Maribel, Delecluse, Henri-Jacques, Esteller, Manel, López-Granados, Eduardo, Fraga, Mario F, López-Bigas, Nuria, Ballestar, Esteban
Publicado 2013

The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

por Kobialka, Piotr, Sabata, Helena, Vilalta, Odena, Gouveia, Leonor, Angulo‐Urarte, Ana, Muixí, Laia, Zanoncello, Jasmina, Muñoz‐Aznar, Oscar, Olaciregui, Nagore G, Fanlo, Lucia, Esteve‐Codina, Anna, Lavarino, Cinzia, Javierre, Biola M, Celis, Veronica, Rovira, Carlota, López‐Fernández, Susana, Baselga, Eulàlia, Mora, Jaume, Castillo, Sandra D, Graupera, Mariona
Publicado 2022

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

por Javierre, Biola M., Burren, Oliver S., Wilder, Steven P., Kreuzhuber, Roman, Hill, Steven M., Sewitz, Sven, Cairns, Jonathan, Wingett, Steven W., Várnai, Csilla, Thiecke, Michiel J., Burden, Frances, Farrow, Samantha, Cutler, Antony J., Rehnström, Karola, Downes, Kate, Grassi, Luigi, Kostadima, Myrto, Freire-Pritchett, Paula, Wang, Fan, Stunnenberg, Hendrik G., Todd, John A., Zerbino, Daniel R., Stegle, Oliver, Ouwehand, Willem H., Frontini, Mattia, Wallace, Chris, Spivakov, Mikhail, Fraser, Peter
Publicado 2016

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

por Petersen, Romina, Lambourne, John J., Javierre, Biola M., Grassi, Luigi, Kreuzhuber, Roman, Ruklisa, Dace, Rosa, Isabel M., Tomé, Ana R., Elding, Heather, van Geffen, Johanna P., Jiang, Tao, Farrow, Samantha, Cairns, Jonathan, Al-Subaie, Abeer M., Ashford, Sofie, Attwood, Antony, Batista, Joana, Bouman, Heleen, Burden, Frances, Choudry, Fizzah A., Clarke, Laura, Flicek, Paul, Garner, Stephen F., Haimel, Matthias, Kempster, Carly, Ladopoulos, Vasileios, Lenaerts, An-Sofie, Materek, Paulina M., McKinney, Harriet, Meacham, Stuart, Mead, Daniel, Nagy, Magdolna, Penkett, Christopher J., Rendon, Augusto, Seyres, Denis, Sun, Benjamin, Tuna, Salih, van der Weide, Marie-Elise, Wingett, Steven W., Martens, Joost H., Stegle, Oliver, Richardson, Sylvia, Vallier, Ludovic, Roberts, David J., Freson, Kathleen, Wernisch, Lorenz, Stunnenberg, Hendrik G., Danesh, John, Fraser, Peter, Soranzo, Nicole, Butterworth, Adam S., Heemskerk, Johan W., Turro, Ernest, Spivakov, Mikhail, Ouwehand, Willem H., Astle, William J., Downes, Kate, Kostadima, Myrto, Frontini, Mattia
Publicado 2017