Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

por Mackness, Brian C., Jaworski, Julie A., Boudanova, Ekaterina, Park, Anna, Valente, Delphine, Mauriac, Christine, Pasquier, Olivier, Schmidt, Thorsten, Kabiri, Mostafa, Kandira, Abdullah, Radošević, Katarina, Qiu, Huawei
Publicado 2019

Engineering an anti-CD52 antibody for enhanced deamidation stability

por Qiu, Huawei, Wei, Ronnie, Jaworski, Julie, Boudanova, Ekaterina, Hughes, Heather, VanPatten, Scott, Lund, Anders, Day, Jaime, Zhou, Yanfeng, McSherry, Tracey, Pan, Clark Q., Sendak, Rebecca
Publicado 2019

Engineered Fc-glycosylation switch to eliminate antibody effector function

por Zhou, Qun, Jaworski, Julie, Zhou, Yanfeng, Valente, Delphine, Cotton, Joanne, Honey, Denise, Boudanova, Ekaterina, Beninga, Jochen, Rao, Ercole, Wei, Ronnie, Mauriac, Christine, Pan, Clark, Park, Anna, Qiu, Huawei
Publicado 2020

A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms

por Stefano, James E., Lord, Dana M., Zhou, Yanfeng, Jaworski, Julie, Hopke, Joern, Travaline, Tara, Zhang, Ningning, Wong, Karen, Lennon, Amanda, He, Timothy, Bric-Furlong, Eva, Cherrie, Cornishia, Magnay, Tristan, Remy, Elisabeth, Brondyk, William, Qiu, Huawei, Radošević, Katarina
Publicado 2021

Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade

por Greco, Rita, Qu, Hongjing, Qu, Hui, Theilhaber, Joachim, Shapiro, Gary, Gregory, Richard, Winter, Christopher, Malkova, Natalia, Sun, Frank, Jaworski, Julie, Best, Annie, Pao, Lily, Hebert, Andrew, Levit, Mikhail, Protopopov, Alexei, Pollard, Jack, Bahjat, Keith, Wiederschain, Dmitri, Sharma, Sharad
Publicado 2020