Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

por Muraoka, Satoshi, Jedrychowski, Mark P., Yanamandra, Kiran, Ikezu, Seiko, Gygi, Steven P., Ikezu, Tsuneya
Publicado 2020

Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

por Tabata, Mitsuhisa, Rodgers, Joseph T., Hall, Jessica A., Lee, Yoonjin, Jedrychowski, Mark P., Gygi, Steven P., Puigserver, Pere
Publicado 2014

Evaluating Multiplexed Quantitative Phosphopeptide Analysis on a Hybrid Quadrupole Mass Filter/Linear Ion Trap/Orbitrap Mass Spectrometer

por Erickson, Brian K., Jedrychowski, Mark P., McAlister, Graeme C., Everley, Robert A., Kunz, Ryan, Gygi, Steven P.
Publicado 2014

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation

por Zeng, Xing, Jedrychowski, Mark P., Chen, Yi, Serag, Sara, Lavery, Gareth G., Gygi, Steve P., Spiegelman, Bruce M.
Publicado 2016

mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

por Shin, Sejeong, Han, Min-Joon, Jedrychowski, Mark P., Zhang, Ziyang, Shokat, Kevan M., Plas, David R., Dephoure, Noah, Yoon, Sang-Oh
Publicado 2023

Innervation of Thermogenic Adipose Tissue via a Calsyntenin-3β/S100b Axis

por Zeng, Xing, Ye, Mengchen, Resch, Jon M., Jedrychowski, Mark P., Hu, Bo, Lowell, Bradford B., Ginty, David D., Spiegelman, Bruce M.
Publicado 2019

Sample multiplexing for targeted pathway proteomics in aging mice

por Yu, Qing, Xiao, Haopeng, Jedrychowski, Mark P., Schweppe, Devin K., Navarrete-Perea, Jose, Knott, Jeffrey, Rogers, John, Chouchani, Edward T., Gygi, Steven P.
Publicado 2020

Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy

por Muraoka, Satoshi, Jedrychowski, Mark P., Tatebe, Harutsugu, DeLeo, Annina M., Ikezu, Seiko, Tokuda, Takahiko, Gygi, Steven P., Stern, Robert A., Ikezu, Tsuneya
Publicado 2019

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

por McAlister, Graeme C., Nusinow, David P., Jedrychowski, Mark P., Wühr, Martin, Huttlin, Edward L., Erickson, Brian K., Rad, Ramin, Haas, Wilhelm, Gygi, Steven P.
Publicado 2014

Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages

por Williams, Niamh C., Ryan, Dylan G., Costa, Ana S.H., Mills, Evanna L., Jedrychowski, Mark P., Cloonan, Suzanne M., Frezza, Christian, O'Neill, Luke A.
Publicado 2021

Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis

por Raju, Ravikiran M., Jedrychowski, Mark P., Wei, Jun-Rong, Pinkham, Jessica T., Park, Annie S., O'Brien, Kathryn, Rehren, German, Schnappinger, Dirk, Gygi, Steven P., Rubin, Eric J.
Publicado 2014

γδT cells and adipocyte IL-17RC control fat innervation and thermogenesis

por Hu, Bo, Jin, Chengcheng, Zeng, Xing, Resch, Jon M., Jedrychowski, Mark P., Yang, Zongfang, Desai, Bhavna N., Banks, Alexander S., Lowell, Bradford B., Mathis, Diane, Spiegelman, Bruce M.
Publicado 2020

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models

por Muraoka, Satoshi, Jedrychowski, Mark P., Iwahara, Naotoshi, Abdullah, Mohammad, Onos, Kristen D., Keezer, Kelly J., Hu, Jianqiao, Ikezu, Seiko, Howell, Gareth R., Gygi, Steven P., Ikezu, Tsuneya
Publicado 2021

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

por Choi, Jang Hyun, Choi, Sun-Sil, Kim, Eun Sun, Jedrychowski, Mark P., Yang, Yong Ryoul, Jang, Hyun-Jun, Suh, Pann-Ghill, Banks, Alexander S., Gygi, Steven P., Spiegelman, Bruce M.
Publicado 2014

Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes

por Jedrychowski, Mark P., Liu, Libin, Laflamme, Collette J., Karastergiou, Kalypso, Meshulam, Tova, Ding, Shi-Ying, Wu, Yuanyuan, Lee, Mi-Jeong, Gygi, Steven P., Fried, Susan K., Pilch, Paul F.
Publicado 2015

Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

por You, Yang, Muraoka, Satoshi, Jedrychowski, Mark P., Hu, Jianqiao, McQuade, Amanda K., Young‐Pearse, Tracy, Aslebagh, Roshanak, Shaffer, Scott A., Gygi, Steven P., Blurton‐Jones, Mathew, Poon, Wayne W., Ikezu, Tsuneya
Publicado 2022

NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms

por Santana-Codina, Naiara, Gableske, Sebastian, del Rey, Maria Quiles, Małachowska, Beata, Jedrychowski, Mark P., Biancur, Douglas E., Schmidt, Paul J., Fleming, Mark D., Fendler, Wojciech, Harper, J. Wade, Kimmelman, Alec C., Mancias, Joseph D.
Publicado 2019

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

por Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.
Publicado 2016

Plasticity in binding confers selectivity in ligand induced protein degradation

por Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.
Publicado 2018

Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity

por Jedrychowski, Mark P., Lu, Gina Z., Szpyt, John, Mariotti, Marco, Garrity, Ryan, Paulo, Joao A., Schweppe, Devin K., Laznik-Bogoslavski, Dina, Kazak, Lawrence, Murphy, Michael P., Gladyshev, Vadim N., Gygi, Steven P., Chouchani, Edward T., Spiegelman, Bruce M.
Publicado 2020