A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism

por Thistlethwaite, Sian, Jeffreys, Laura N., Girvan, Hazel M., McLean, Kirsty J., Munro, Andrew W.
Publicado 2021

Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches

por Jeffreys, Laura N., Pacholarz, Kamila J., Johannissen, Linus O., Girvan, Hazel M., Barran, Perdita E., Voice, Michael W., Munro, Andrew W.
Publicado 2020

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

por Jeffreys, Laura N., Poddar, Harshwardhan, Golovanova, Marina, Levy, Colin W., Girvan, Hazel M., McLean, Kirsty J., Voice, Michael W., Leys, David, Munro, Andrew W.
Publicado 2019

Structural deformability induced in proteins of potential interest associated with COVID-19 by binding of homologues present in ivermectin: Comparative study based in elastic netwo...

por González-Paz, Lenin, Hurtado-León, María Laura, Lossada, Carla, Fernández-Materán, Francelys V., Vera-Villalobos, Joan, Loroño, Marcos, Paz, J.L., Jeffreys, Laura, Alvarado, Ysaias J.
Publicado 2021

Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach

por González-Paz, Lenin, Hurtado-León, María Laura, Lossada, Carla, Fernández-Materán, Francelys V., Vera-Villalobos, Joan, Loroño, Marcos, Paz, J.L., Jeffreys, Laura, Alvarado, Ysaias J.
Publicado 2021

Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors

por González-Paz, Lenin, Alvarado, María José, Hurtado-León, María Laura, Lossada, Carla, Vera-Villalobos, Joan, Loroño, Marcos, Paz, J.L., Jeffreys, Laura N., Torres, F. Javier, Alvarado, Ysaias J.
Publicado 2022

Interaction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic net...

por Alvarado, Ysaias José, Olivarez, Yosmari, Lossada, Carla, Vera-Villalobos, Joan, Paz, José Luis, Vera, Eddy, Loroño, Marcos, Vivas, Alejandro, Torres, Fernando Javier, Jeffreys, Laura N., Hurtado-León, María Laura, González-Paz, Lenin
Publicado 2022

Redox driven B(12)-ligand switch drives CarH photoresponse

por Poddar, Harshwardhan, Rios-Santacruz, Ronald, Heyes, Derren J., Shanmugam, Muralidharan, Brookfield, Adam, Johannissen, Linus O., Levy, Colin W., Jeffreys, Laura N., Zhang, Shaowei, Sakuma, Michiyo, Colletier, Jacques-Philippe, Hay, Sam, Schirò, Giorgio, Weik, Martin, Scrutton, Nigel S., Leys, David
Publicado 2023

Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays

por Box, Helen, Pennington, Shaun H, Kijak, Edyta, Tatham, Lee, Caygill, Claire H, Lopeman, Rose C, Jeffreys, Laura N, Herriott, Joanne, Sharp, Joanne, Neary, Megan, Valentijn, Anthony, Pertinez, Henry, Curley, Paul, Arshad, Usman, Rajoli, Rajith KR, Rannard, Steve, Stewart, James P., Biagini, Giancarlo A, Owen, Andrew
Publicado 2022

Remdesivir–ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2

por Jeffreys, Laura N., Pennington, Shaun H., Duggan, Jack, Caygill, Claire H., Lopeman, Rose C., Breen, Alastair F., Jinks, Jessica B., Ardrey, Alison, Donnellan, Samantha, Patterson, Edward I., Hughes, Grant L., Hong, David W., O'Neill, Paul M., Aljayyoussi, Ghaith, Owen, Andrew, Ward, Stephen A., Biagini, Giancarlo A.
Publicado 2022

Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis

por Jeffreys, Laura N., Ardrey, Alison, Hafiz, Taghreed A., Dyer, Lauri-Anne, Warman, Ashley J., Mosallam, Nada, Nixon, Gemma L., Fisher, Nicholas E., Hong, W. David, Leung, Suet C., Aljayyoussi, Ghaith, Bibby, Jaclyn, Almeida, Deepak V., Converse, Paul J., Fotouhi, Nader, Berry, Neil G., Nuermberger, Eric L., Upton, Anna M., O’Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Publicado 2023