Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

por Ricke, Robin M., Jeganathan, Karthik B., van Deursen, Jan M.
Publicado 2011

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

por van Ree, Janine H., Jeganathan, Karthik B., Malureanu, Liviu, van Deursen, Jan M.
Publicado 2010

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

por Jeganathan, Karthik, Malureanu, Liviu, Baker, Darren J., Abraham, Susan C., van Deursen, Jan M.
Publicado 2007

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

por Ricke, Robin M., Jeganathan, Karthik B., Malureanu, Liviu, Harrison, Andrew M., van Deursen, Jan M.
Publicado 2012

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

por Baker, Darren J., Jeganathan, Karthik B., Malureanu, Liviu, Perez-Terzic, Carmen, Terzic, Andre, van Deursen, Jan M.A.
Publicado 2006

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

por Babu, J. Ramesh, Jeganathan, Karthik B., Baker, Darren J., Wu, Xiaosheng, Kang-Decker, Ningling, van Deursen, Jan M.
Publicado 2003

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice

por Jin, Fang, Hamada, Masakazu, Malureanu, Liviu, Jeganathan, Karthik B., Zhou, Wei, Morbeck, Dean E., van Deursen, Jan M.
Publicado 2010

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

por Wijshake, Tobias, Malureanu, Liviu A., Baker, Darren J., Jeganathan, Karthik B., van de Sluis, Bart, van Deursen, Jan M.
Publicado 2012

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

por Weaver, Robbyn L, Limzerwala, Jazeel F, Naylor, Ryan M, Jeganathan, Karthik B, Baker, Darren J, van Deursen, Jan M
Publicado 2016

Senescent cells limit p53 activity via multiple mechanisms to remain viable

por Sturmlechner, Ines, Sine, Chance C., Jeganathan, Karthik B., Zhang, Cheng, Fierro Velasco, Raul O., Baker, Darren J., Li, Hu, van Deursen, Jan M.
Publicado 2022

Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability

por Hamada, Masakazu, Haeger, Anna, Jeganathan, Karthik B., van Ree, Janine H., Malureanu, Liviu, Wälde, Sarah, Joseph, Jomon, Kehlenbach, Ralph H., van Deursen, Jan M.
Publicado 2011

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

por Malureanu, Liviu, Jeganathan, Karthik B., Jin, Fang, Baker, Darren J., van Ree, Janine H., Gullon, Oliver, Chen, Zheyan, Henley, John R., van Deursen, Jan M.
Publicado 2010

Spartan deficiency causes genomic instability and progeroid phenotypes

por Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.
Publicado 2014

Hyperphosphorylated PTEN exerts oncogenic properties

por van Ree, Janine H., Jeganathan, Karthik B., Fierro Velasco, Raul O., Zhang, Cheng, Can, Ismail, Hamada, Masakazu, Li, Hu, Baker, Darren J., van Deursen, Jan M.
Publicado 2023

Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression

por Aziz, Khaled, Sieben, Cynthia J., Jeganathan, Karthik B., Hamada, Masakazu, Davies, Brian A., Velasco, Raul O. Fierro, Rahman, Nazneen, Katzmann, David J., van Deursen, Jan M.
Publicado 2018

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

por Nowsheen, Somaira, Aziz, Khaled, Luo, Kuntian, Deng, Min, Qin, Bo, Yuan, Jian, Jeganathan, Karthik B., Yu, Jia, Zhang, Henan, Ding, Wei, van Deursen, Jan M., Lou, Zhenkun
Publicado 2018

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

por Baker, Darren J., Childs, Bennett G., Durik, Matej, Wijers, Melinde E., Sieben, Cynthia J., Zhong, Jian, Saltness, Rachel, Jeganathan, Karthik B., Versoza, Grace C., Pezeshki, Abdul-Mohammad, Khazaie, Khashayarsha, Miller, Jordan D., van Deursen, Jan M.
Publicado 2016

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

por Baker, Darren J., Dawlaty, Meelad M., Wijshake, Tobias, Jeganathan, Karthik B., Malureanu, Liviu, van Ree, Janine H., Crespo-Diaz, Ruben, Reyes, Santiago, Seaburg, Lauren, Shapiro, Virginia, Behfar, Atta, Terzic, Andre, van de Sluis, Bart, van Deursen, Jan M.
Publicado 2012