Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins

por De Marco Verissimo, Carolina, Jewhurst, Heather L., Dobó, József, Gál, Péter, Dalton, John P., Cwiklinski, Krystyna
Publicado 2022

Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases

por De Marco Verissimo, Carolina, Jewhurst, Heather L., Tikhonova, Irina G., Urbanus, Rolf T., Maule, Aaron G., Dalton, John P., Cwiklinski, Krystyna
Publicado 2020

Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES

por Smith, David, Tikhonova, Irina G., Jewhurst, Heather L., Drysdale, Orla C., Dvořák, Jan, Robinson, Mark W., Cwiklinski, Krystyna, Dalton, John P.
Publicado 2016

Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition

por Pritsch, Izanara C., Tikhonova, Irina G., Jewhurst, Heather L., Drysdale, Orla, Cwiklinski, Krystyna, Molento, Marcelo B., Dalton, John P., Verissimo, Carolina De M.
Publicado 2020

Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system

por De Marco Verissimo, Carolina, López Corrales, Jesús, Dorey, Amber L., Cwiklinski, Krystyna, Lalor, Richard, Calvani, Nichola Eliza Davies, Jewhurst, Heather L., Flaus, Andrew, Doyle, Sean, Dalton, John P.
Publicado 2022

Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells

por de la Torre-Escudero, Eduardo, Gerlach, Jared Q., Bennett, Adam P. S., Cwiklinski, Krystyna, Jewhurst, Heather L., Huson, Kathryn M., Joshi, Lokesh, Kilcoyne, Michelle, O’Neill, Sandra, Dalton, John P., Robinson, Mark W.
Publicado 2019