PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation

por Guan, Wen-Liang, Jiang, Lei-Lei, Yin, Xiao-Fang, Hu, Hong-Yu
Publicado 2023

PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates

por Yue, Hong-Wei, Hong, Jun-Ye, Zhang, Shu-Xian, Jiang, Lei-Lei, Hu, Hong-Yu
Publicado 2021

Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

por Jiang, Lei-Lei, Zhao, Jian, Yin, Xiao-Fang, He, Wen-Tian, Yang, Hui, Che, Mei-Xia, Hu, Hong-Yu
Publicado 2016

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

por He, Wen-Tian, Xue, Wei, Gao, Yong-Guang, Hong, Jun-Ye, Yue, Hong-Wei, Jiang, Lei-Lei, Hu, Hong-Yu
Publicado 2017

Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis: Coaggregation of polyQ proteins

por Hong, Jun-Ye, Wang, Jian-Yang, Yue, Hong-Wei, Zhang, Xiang-Le, Zhang, Shu-Xian, Jiang, Lei-Lei, Hu, Hong-Yu
Publicado 2023

Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation

por Hong, Jun-Ye, Wang, Dong-Dong, Xue, Wei, Yue, Hong-Wei, Yang, Hui, Jiang, Lei-Lei, Wang, Wen-Ning, Hu, Hong-Yu
Publicado 2019

Author Correction: Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation

por Hong, Jun-Ye, Xue, Wei, Yue, Hong-Wei, Yang, Hui, Jiang, Lei-Lei, Hu, Hong-Yu, Wang, Dong-Dong, Wang, Wen-Ning
Publicado 2020

The N-terminal dimerization is required for TDP-43 splicing activity

por Jiang, Lei-Lei, Xue, Wei, Hong, Jun-Ye, Zhang, Jun-Ting, Li, Min-Jun, Yu, Shao-Ning, He, Jian-Hua, Hu, Hong-Yu
Publicado 2017