ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

por Zhu, Bing, Jiang, LuLin, Huang, Timothy, Zhao, Yingjun, Liu, Tongfei, Zhong, Yongwang, Li, Xiaoguang, Campos, Alexandre, Pomeroy, Kenneth, Masliah, Eliezer, Zhang, Dongxian, Xu, Huaxi
Publicado 2017

Intracellular trafficking of TREM2 is regulated by presenilin 1

por Zhao, Yingjun, Li, Xiaoguang, Huang, Timothy, Jiang, Lu-lin, Tan, Zhenqiu, Zhang, Muxian, Cheng, Irene Han-Juo, Wang, Xin, Bu, Guojun, Zhang, Yun-wu, Wang, Qi, Xu, Huaxi
Publicado 2017

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

por Huang, Timothy Y., Zhao, Yingjun, Jiang, Lu-lin, Li, Xiaoguang, Liu, Yan, Sun, Yu, Piña-Crespo, Juan C., Zhu, Bing, Masliah, Eliezer, Willnow, Thomas E., Pasquale, Elena B., Xu, Huaxi
Publicado 2017

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

por Zhao, Peng, Xu, Yuanzhong, Jiang, Lu-Lin, Fan, Xuejun, Ku, Zhiqiang, Li, Leike, Liu, Xiaoye, Deng, Mi, Arase, Hisashi, Zhu, Jay-Jiguang, Huang, Timothy Y., Zhao, Yingjun, Zhang, Chengcheng, Xu, Huaxi, Tong, Qingchun, Zhang, Ningyan, An, Zhiqiang
Publicado 2022

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease

por Xu, Peng, Chang, Jerry C., Zhou, Xiaopu, Wang, Wei, Bamkole, Michael, Wong, Eitan, Bettayeb, Karima, Jiang, Lu-Lin, Huang, Timothy, Luo, Wenjie, Xu, Huaxi, Nairn, Angus C., Flajolet, Marc, Ip, Nancy Y., Li, Yue-Ming, Greengard, Paul
Publicado 2021

Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE

por Liu, Tongfei, Zhu, Bing, Liu, Yan, Zhang, Xiaoming, Yin, Jun, Li, Xiaoguang, Jiang, LuLin, Hodges, Andrew P., Rosenthal, Sara Brin, Zhou, Lisa, Yancey, Joel, McQuade, Amanda, Blurton-Jones, Mathew, Tanzi, Rudolph E., Huang, Timothy Y., Xu, Huaxi
Publicado 2020

USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

por Zheng, Qiuyang, Song, Beibei, Li, Guilin, Cai, Fang, Wu, Meiling, Zhao, Yingjun, Jiang, LuLin, Guo, Tiantian, Shen, Mingyu, Hou, Huan, Zhou, Ying, Zhao, Yini, Di, Anjie, Zhang, Lishan, Zeng, Fanwei, Zhang, Xiu-Fang, Luo, Hong, Zhang, Xian, Zhang, Hongfeng, Zeng, Zhiping, Huang, Timothy Y., Dong, Chen, Qing, Hong, Zhang, Yun, Zhang, Qing, Wang, Xu, Wu, Yili, Xu, Huaxi, Song, Weihong, Wang, Xin
Publicado 2022