Genetic Drivers of Multidrug Resistance in Candida glabrata

por Healey, Kelley R., Jimenez Ortigosa, Cristina, Shor, Erika, Perlin, David S.
Publicado 2016

Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis

por Jiménez-Ortigosa, Cristina, Moore, Caroline, Denning, David W., Perlin, David S.
Publicado 2017

Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells

por Garcia-Rubio, Rocio, Jimenez-Ortigosa, Cristina, DeGregorio, Lucius, Quinteros, Christopher, Shor, Erika, Perlin, David S.
Publicado 2021

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility

por Healey, Kelley R., Kordalewska, Milena, Jiménez Ortigosa, Cristina, Singh, Ashutosh, Berrío, Indira, Chowdhary, Anuradha, Perlin, David S.
Publicado 2018

Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1

por Healey, Kelley R., Paderu, Padmaja, Hou, Xin, Jimenez Ortigosa, Cristina, Bagley, Nicole, Patel, Biren, Zhao, Yanan, Perlin, David S.
Publicado 2020

CD101: a novel long‐acting echinocandin

por Zhao, Yanan, Perez, Winder B., Jiménez‐Ortigosa, Cristina, Hough, Grayson, Locke, Jeffrey B., Ong, Voon, Bartizal, Ken, Perlin, David S.
Publicado 2016

Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis

por Zhao, Yanan, Lee, Min Hee, Paderu, Padmaja, Lee, Annie, Jimenez-Ortigosa, Cristina, Park, Steven, Mansbach, Robert S., Shaw, Karen Joy, Perlin, David S.
Publicado 2018

Preliminary Structural Elucidation of β-(1,3)-glucan Synthase from Candida glabrata Using Cryo-Electron Tomography

por Jiménez-Ortigosa, Cristina, Jiang, Jennifer, Chen, Muyuan, Kuang, Xuyuan, Healey, Kelley R., Castellano, Paul, Boparai, Nikpreet, Ludtke, Steven J., Perlin, David S., Dai, Wei
Publicado 2021

Echinocandin-resistant Candida tropicalis Bloodstream Infections

por Sfeir, Maroun, Jiménez-Ortigosa, Cristina, Schuetz, Audrey, Jenkins, Stephen, Jones, Sian, Soave, Rosemary, Van Besien, Koen, Satlin, Michael, Small, Catherine, Perlin, David, Walsh, Thomas
Publicado 2017

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

por Sfeir, Maroun M., Jiménez-Ortigosa, Cristina, Gamaletsou, Maria N., Schuetz, Audrey N., Soave, Rosemary, Van Besien, Koen, Small, Catherine B., Perlin, David S., Walsh, Thomas J.
Publicado 2020

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

por Satish, Shruthi, Jiménez-Ortigosa, Cristina, Zhao, Yanan, Lee, Min Hee, Dolgov, Enriko, Krüger, Thomas, Park, Steven, Denning, David W., Kniemeyer, Olaf, Brakhage, Axel A., Perlin, David S.
Publicado 2019

Antifungal Drug Susceptibility and Genetic Characterization of Fungi Recovered from COVID-19 Patients

por Kordalewska, Milena, Guerrero, Kevin D., Garcia-Rubio, Rocio, Jiménez-Ortigosa, Cristina, Mediavilla, José R., Cunningham, Marcus H., Hollis, Frank, Hong, Tao, Chow, Kar Fai, Kreiswirth, Barry N., Perlin, David S.
Publicado 2021

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

por Healey, Kelley R., Zhao, Yanan, Perez, Winder B., Lockhart, Shawn R., Sobel, Jack D., Farmakiotis, Dimitrios, Kontoyiannis, Dimitrios P., Sanglard, Dominique, Taj-Aldeen, Saad J., Alexander, Barbara D., Jimenez-Ortigosa, Cristina, Shor, Erika, Perlin, David S.
Publicado 2016