Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis

por Jin, Meihua, Jin, Xiaocen, Homma, Hidenori, Fujita, Kyota, Tanaka, Hikari, Murayama, Shigeo, Akatsu, Hiroyasu, Tagawa, Kazuhiko, Okazawa, Hitoshi
Publicado 2021

PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions

por Jin, Xiaocen, Tanaka, Hikari, Jin, Meihua, Fujita, Kyota, Homma, Hidenori, Inotsume, Maiko, Yong, Huang, Umeda, Kenichi, Kodera, Noriyuki, Ando, Toshio, Okazawa, Hitoshi
Publicado 2023

Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

por Jin, Meihua, Shiwaku, Hiroki, Tanaka, Hikari, Obita, Takayuki, Ohuchi, Sakurako, Yoshioka, Yuki, Jin, Xiaocen, Kondo, Kanoh, Fujita, Kyota, Homma, Hidenori, Nakajima, Kazuyuki, Mizuguchi, Mineyuki, Okazawa, Hitoshi
Publicado 2021

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

por Tanaka, Hikari, Kondo, Kanoh, Fujita, Kyota, Homma, Hidenori, Tagawa, Kazuhiko, Jin, Xiaocen, Jin, Meihua, Yoshioka, Yuki, Takayama, Sumire, Masuda, Hitomi, Tokuyama, Rie, Nakazaki, Yukoh, Saito, Takashi, Saido, Takaomi, Murayama, Shigeo, Ikura, Teikichi, Ito, Nobutoshi, Yamamori, Yu, Tomii, Kentaro, Bianchi, Marco E., Okazawa, Hitoshi
Publicado 2021

DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis

por Homma, Hidenori, Tanaka, Hikari, Jin, Meihua, Jin, Xiaocen, Huang, Yong, Yoshioka, Yuki, Bertens, Christian JF, Tsumaki, Kohei, Kondo, Kanoh, Shiwaku, Hiroki, Tagawa, Kazuhiko, Akatsu, Hiroyasu, Atsuta, Naoki, Katsuno, Masahisa, Furukawa, Katsutoshi, Ishiki, Aiko, Waragai, Masaaki, Ohtomo, Gaku, Iwata, Atsushi, Yokota, Takanori, Inoue, Haruhisa, Arai, Hiroyuki, Sobue, Gen, Sone, Masaki, Fujita, Kyota, Okazawa, Hitoshi
Publicado 2021

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

por Tanaka, Hikari, Homma, Hidenori, Fujita, Kyota, Kondo, Kanoh, Yamada, Shingo, Jin, Xiaocen, Waragai, Masaaki, Ohtomo, Gaku, Iwata, Atsushi, Tagawa, Kazuhiko, Atsuta, Naoki, Katsuno, Masahisa, Tomita, Naoki, Furukawa, Katsutoshi, Saito, Yuko, Saito, Takashi, Ichise, Ayaka, Shibata, Shinsuke, Arai, Hiroyuki, Saido, Takaomi, Sudol, Marius, Muramatsu, Shin-ichi, Okano, Hideyuki, Mufson, Elliott J., Sobue, Gen, Murayama, Shigeo, Okazawa, Hitoshi
Publicado 2020