New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

por Sticova, Eva, Jirsa, Milan, Pawłowska, Joanna
Publicado 2018

The first Turkish family with Rotor syndrome diagnosed at the molecular level

por Gümüş, Evren, Karaca, Meryem, Deveci, Uğur, Jirsa, Milan
Publicado 2020

Iron oxide nanoparticles trigger endoplasmic reticulum damage in steatotic hepatic cells

por Uzhytchak, Mariia, Lunova, Mariia, Smolková, Barbora, Jirsa, Milan, Dejneka, Alexandr, Lunov, Oleg
Publicado 2023

ATP8B1 Gene Expression Is Driven by a Housekeeping-Like Promoter Independent of Bile Acids and Farnesoid X Receptor

por Cebecauerová, Dita, Strautnieks, Sandra S., Byrne, Jane A., Jirsa, Milan, Thompson, Richard J.
Publicado 2012

Alagille Syndrome Mimicking Biliary Atresia in Early Infancy

por Dědič, Tomáš, Jirsa, Milan, Keil, Radan, Rygl, Michal, Šnajdauf, Jiri, Kotalová, Radana
Publicado 2015

Chemically different non-thermal plasmas target distinct cell death pathways

por Lunov, Oleg, Zablotskii, Vitalii, Churpita, Olexander, Lunova, Mariia, Jirsa, Milan, Dejneka, Alexandr, Kubinová, Šárka
Publicado 2017

Mechanical Regulation of Mitochondrial Dynamics and Function in a 3D-Engineered Liver Tumor Microenvironment

por Frtús, Adam, Smolková, Barbora, Uzhytchak, Mariia, Lunova, Mariia, Jirsa, Milan, Petrenko, Yuriy, Dejneka, Alexandr, Lunov, Oleg
Publicado 2023

USP18 downregulation in peripheral blood mononuclear cells predicts nonresponse to interferon-based triple therapy in patients with chronic hepatitis C, genotype 1: a pilot study

por Frankova, Sona, Jirsa, Milan, Merta, Dusan, Neroldova, Magdalena, Urbanek, Petr, Senkerikova, Renata, Spicak, Julius, Sperl, Jan
Publicado 2015

Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview

por Lunova, Mariia, Smolková, Barbora, Lynnyk, Anna, Uzhytchak, Mariia, Jirsa, Milan, Kubinová, Šárka, Dejneka, Alexandr, Lunov, Oleg
Publicado 2019

Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells

por Uzhytchak, Mariia, Smolková, Barbora, Lunova, Mariia, Jirsa, Milan, Frtús, Adam, Kubinová, Šárka, Dejneka, Alexandr, Lunov, Oleg
Publicado 2020

Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines

por Lunova, Mariia, Prokhorov, Andrey, Jirsa, Milan, Hof, Martin, Olżyńska, Agnieszka, Jurkiewicz, Piotr, Kubinová, Šárka, Lunov, Oleg, Dejneka, Alexandr
Publicado 2017

PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age

por Senkerikova, Renata, Frankova, Sona, Jirsa, Milan, Kreidlova, Miluse, Merta, Dusan, Neroldova, Magdalena, Chmelova, Klara, Spicak, Julius, Sperl, Jan
Publicado 2019

Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling

por Lunova, Mariia, Kubovciak, Jan, Smolková, Barbora, Uzhytchak, Mariia, Michalova, Kyra, Dejneka, Alexandr, Strnad, Pavel, Lunov, Oleg, Jirsa, Milan
Publicado 2021

Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrho...

por Frankova, Sona, Lunova, Mariia, Gottfriedova, Halima, Senkerikova, Renata, Neroldova, Magdalena, Kovac, Jozef, Kieslichova, Eva, Lanska, Vera, Urbanek, Petr, Spicak, Julius, Jirsa, Milan, Sperl, Jan
Publicado 2021

Hepatic Tumor Cell Morphology Plasticity under Physical Constraints in 3D Cultures Driven by YAP–mTOR Axis

por Frtús, Adam, Smolková, Barbora, Uzhytchak, Mariia, Lunova, Mariia, Jirsa, Milan, Hof, Martin, Jurkiewicz, Piotr, Lozinsky, Vladimir I., Wolfová, Lucie, Petrenko, Yuriy, Kubinová, Šárka, Dejneka, Alexandr, Lunov, Oleg
Publicado 2020

Remote Actuation of Apoptosis in Liver Cancer Cells via Magneto-Mechanical Modulation of Iron Oxide Nanoparticles

por Lunov, Oleg, Uzhytchak, Mariia, Smolková, Barbora, Lunova, Mariia, Jirsa, Milan, Dempsey, Nora M., Dias, André L., Bonfim, Marlio, Hof, Martin, Jurkiewicz, Piotr, Petrenko, Yuri, Kubinová, Šárka, Dejneka, Alexandr
Publicado 2019

Alpha-1 Antitrypsin and Hepatocellular Carcinoma in Liver Cirrhosis: SERPINA1 MZ or MS Genotype Carriage Decreases the Risk

por Rabekova, Zuzana, Frankova, Sona, Jirsa, Milan, Neroldova, Magdalena, Lunova, Mariia, Fabian, Ondrej, Kveton, Martin, Varys, David, Chmelova, Klara, Adamkova, Vera, Hubacek, Jaroslav A., Spicak, Julius, Merta, Dusan, Sperl, Jan
Publicado 2021

Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis

por Levada, Kateryna, Pshenichnikov, Stanislav, Omelyanchik, Alexander, Rodionova, Valeria, Nikitin, Aleksey, Savchenko, Alexander, Schetinin, Igor, Zhukov, Dmitry, Abakumov, Maxim, Majouga, Alexander, Lunova, Mariia, Jirsa, Milan, Smolková, Barbora, Uzhytchak, Mariia, Dejneka, Alexandr, Lunov, Oleg
Publicado 2020

Transcript, protein, metabolite and cellular studies in skin fibroblasts demonstrate variable pathogenic impacts of NPC1 mutations

por Musalkova, Dita, Majer, Filip, Kuchar, Ladislav, Luksan, Ondrej, Asfaw, Befekadu, Vlaskova, Hana, Storkanova, Gabriela, Reboun, Martin, Poupetova, Helena, Jahnova, Helena, Hulkova, Helena, Ledvinova, Jana, Dvorakova, Lenka, Sikora, Jakub, Jirsa, Milan, Vanier, Marie T., Hrebicek, Martin
Publicado 2020

Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease

por Neřoldová, Magdaléna, Ciara, Elżbieta, Slatinská, Janka, Fraňková, Soňa, Lišková, Petra, Kotalová, Radana, Globinovská, Janka, Šafaříková, Markéta, Pfeiferová, Lucie, Zůnová, Hana, Mrázová, Lenka, Stránecký, Viktor, Vrbacká, Alena, Fabián, Ondřej, Sticová, Eva, Skanderová, Daniela, Šperl, Jan, Kalousová, Marta, Zima, Tomáš, Macek, Milan, Pawlowska, Joanna, Knisely, A. S., Kmoch, Stanislav, Jirsa, Milan
Publicado 2023