Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors()

por Job, Albert, Schmitt, Lisa-Maria, von Wenserski, Lisa, Lankat-Buttgereit, Brigitte, Gress, Thomas M., Buchholz, Malte, Gallmeier, Eike
Publicado 2018

A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers

por Hocke, Sandra, Guo, Yang, Job, Albert, Orth, Michael, Ziesch, Andreas, Lauber, Kirsten, De Toni, Enrico N, Gress, Thomas M., Herbst, Andreas, Göke, Burkhard, Gallmeier, Eike
Publicado 2016

The POLD1(R689W) variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors

por Job, Albert, Tatura, Marina, Schäfer, Cora, Lutz, Veronika, Schneider, Hanna, Lankat-Buttgereit, Brigitte, Zielinski, Alexandra, Borgmann, Kerstin, Bauer, Christian, Gress, Thomas M., Buchholz, Malte, Gallmeier, Eike
Publicado 2020