Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen

por Schepers, Arnout, Jochems, Fleur, Lieftink, Cor, Wang, Liqin, Pogacar, Ziva, Leite de Oliveira, Rodrigo, De Conti, Giulia, Beijersbergen, Roderick L., Bernards, Rene
Publicado 2021

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

por Jin, Haojie, Wang, Siying, Zaal, Esther A, Wang, Cun, Wu, Haiqiu, Bosma, Astrid, Jochems, Fleur, Isima, Nikita, Jin, Guangzhi, Lieftink, Cor, Beijersbergen, Roderick, Berkers, Celia R, Qin, Wenxin, Bernards, Rene
Publicado 2020

The Cancer SENESCopedia: A delineation of cancer cell senescence

por Jochems, Fleur, Thijssen, Bram, De Conti, Giulia, Jansen, Robin, Pogacar, Ziva, Groot, Kelvin, Wang, Liqin, Schepers, Arnout, Wang, Cun, Jin, Haojie, Beijersbergen, Roderick L., Leite de Oliveira, Rodrigo, Wessels, Lodewyk F.A., Bernards, René
Publicado 2021

Genetic and compound screens uncover factors modulating cancer cell response to indisulam

por Pogacar, Ziva, Groot, Kelvin, Jochems, Fleur, Dos Santos Dias, Matheus, Mulero-Sánchez, Antonio, Morris, Ben, Roosen, Mieke, Wardak, Leyma, De Conti, Giulia, Velds, Arno, Lieftink, Cor, Thijssen, Bram, Beijersbergen, Roderick L, Bernards, René, Leite de Oliveira, Rodrigo
Publicado 2022

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

por Pogacar, Ziva, Johnson, Jackie L., Krenning, Lenno, De Conti, Giulia, Jochems, Fleur, Lieftink, Cor, Velds, Arno, Wardak, Leyma, Groot, Kelvin, Schepers, Arnout, Wang, Liqin, Song, Ji-Ying, van de Ven, Marieke, van Tellingen, Olaf, Medema, Rene H., Beijersbergen, Roderick L., Bernards, Rene, Leite de Oliveira, Rodrigo
Publicado 2022

Inducing and exploiting vulnerabilities for the treatment of liver cancer

por Wang, Cun, Vegna, Serena, Jin, Haojie, Benedict, Bente, Lieftink, Cor, Ramirez, Christel, Leite de Oliveira, Rodrigo, Morris, Ben, Gadiot, Jules, Wang, Wei, du Chatinier, Aimée, Wang, Liqin, Gao, Dongmei, Evers, Bastiaan, Jin, Guangzhi, Xue, Zheng, Schepers, Arnout, Jochems, Fleur, Mulero Sanchez, Antonio, Mainardi, Sara, te Riele, Hein, Beijersbergen, Roderick L., Qin, Wenxin, Akkari, Leila, Bernards, René
Publicado 2019