Next generation therapeutics for Alzheimer's disease

por Bredesen, Dale E, John, Varghese
Publicado 2013

Designing Physical Human-Robot Interaction Interfaces: A Scalable Method for Simulation Based Design

por John Varghese, Rohit, Mukherjee, Gaurav, Deshpande, Ashish
Publicado 2022

Nanoscale Extracellular Vesicle Analysis in Alzheimer's Disease Diagnosis and Therapy

por Heinzelman, Pete, Bilousova, Tina, Campagna, Jesus, John, Varghese
Publicado 2016

Ayurvedic medicinal plants for Alzheimer's disease: a review

por Rao, Rammohan V, Descamps, Olivier, John, Varghese, Bredesen, Dale E
Publicado 2012

Altering APP Proteolysis: Increasing sAPPalpha Production by Targeting Dimerization of the APP Ectodomain

por Libeu, Clare A. Peters, Descamps, Olivier, Zhang, Qiang, John, Varghese, Bredesen, Dale E.
Publicado 2012

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans

por Maccecchini, Maria L, Chang, Mee Young, Pan, Catherine, John, Varghese, Zetterberg, Henrik, Greig, Nigel H
Publicado 2012

Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery

por Subbiah, Naren, Campagna, Jesus, Spilman, Patricia, Alam, Mohammad Parvez, Sharma, Shivani, Hokugo, Akishige, Nishimura, Ichiro, John, Varghese
Publicado 2017

High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy

por Shu, Cynthia, Parfenova, Liubov, Mokhonova, Ekaterina, Collado, Judd R., Damoiseaux, Robert, Campagna, Jesus, John, Varghese, Crosbie, Rachelle H.
Publicado 2020

Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures

por Cohn, Whitaker, Melnik, Mikhail, Huang, Calvin, Teter, Bruce, Chandra, Sujyoti, Zhu, Chunni, McIntire, Laura Beth, John, Varghese, Gylys, Karen H., Bilousova, Tina
Publicado 2021

A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy

por Liu, Jian, Campagna, Jesus, John, Varghese, Damoiseaux, Robert, Mokhonova, Ekaterina, Becerra, Diana, Meng, Huan, McNally, Elizabeth M., Pyle, April D., Kramerova, Irina, Spencer, Melissa J.
Publicado 2020

GoCoronaGo: Privacy Respecting Contact Tracing for COVID-19 Management

por Simmhan, Yogesh, Rambha, Tarun, Khochare, Aakash, Ramesh, Shriram, Baranawal, Animesh, George, John Varghese, Bhope, Rahul Atul, Namtirtha, Amrita, Sundararajan, Amritha, Bhargav, Sharath Suresh, Thakkar, Nihar, Kiran, Raj
Publicado 2020

Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production

por Poksay, Karen S., Sheffler, Douglas J., Spilman, Patricia, Campagna, Jesus, Jagodzinska, Barbara, Descamps, Olivier, Gorostiza, Olivia, Matalis, Alex, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D. P., John, Varghese
Publicado 2017

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

por Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese
Publicado 2021

Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

por Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese
Publicado 2021

Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

por Okawa, Hiroko, Kondo, Takeru, Hokugo, Akishige, Cherian, Philip, Sundberg, Oskar, Campagna, Jesus J., Kashemirov, Boris A., John, Varghese, Sun, Shuting, Ebetino, Frank H., McKenna, Charles E., Nishimura, Ichiro
Publicado 2022

Epidemiology of hospital-based COVID- 19 cluster in a tertiary care cancer hospital, Chennai, India 2020

por Barani, Suganya, Jahan, Nuzrath, Karuppiah, Mathan, Chaudhuri, Sirshendu, Raju, Mohankumar, Ponnaiah, Manickam, Rajaraman, Swaminathan, Vaidhyalingam, Venktesh, Ganeshkumar, Parasuraman, Kumar CP, Girish, Muthappan, Sendhilkumar, Murugesan, Jegadeesan, Srinivasan, Mahalakshmi, Krishnan, Usha, John Varghese, Alby
Publicado 2021

Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue

por Cohn, Whitaker, Zhu, Chunni, Campagna, Jesus, Bilousova, Tina, Spilman, Patricia, Teter, Bruce, Li, Feng, Guo, Rong, Elashoff, David, Cole, Greg M., Avidan, Alon, Faull, Kym Francis, Whitelegge, Julian, Wong, David T. W., John, Varghese
Publicado 2022

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model

por Campagna, Jesus, Spilman, Patricia, Jagodzinska, Barbara, Bai, Dongsheng, Hatami, Asa, Zhu, Chunni, Bilousova, Tina, Jun, Michael, Elias, Chris Jean, Pham, Johnny, Cole, Gregory, LaDu, Mary Jo, Jung, Michael E., Bredesen, Dale E., John, Varghese
Publicado 2018

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene dipho...

por Okawa, Hiroko, Kondo, Takeru, Hokugo, Akishige, Cherian, Philip, Campagna, Jesus J, Lentini, Nicholas A, Sung, Eric C, Chiang, Samantha, Lin, Yi-Ling, Ebetino, Frank H, John, Varghese, Sun, Shuting, McKenna, Charles E, Nishimura, Ichiro
Publicado 2022

Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta

por Miyoshi, Emily, Bilousova, Tina, Melnik, Mikhail, Fakhrutdinov, Danyl, Poon, Wayne W., Vinters, Harry V., Miller, Carol A., Corrada, Maria, Kawas, Claudia, Bohannan, Ryan, Caraway, Chad, Elias, Chris, Maina, Katherine N., Campagna, Jesus J., John, Varghese, Gylys, Karen Hoppens
Publicado 2021