The Current Landscape of Marijuana and Pharmacogenetics

por Rambaran, Kerry Anne, Chu, Michael, Johnson, Tyler B, Alzghari, Saeed K
Publicado 2017

A tailored Cln3(Q352X) mouse model for testing therapeutic interventions in CLN3 Batten disease

por Langin, Logan, Johnson, Tyler B., Kovács, Attila D., Pearce, David A., Weimer, Jill M.
Publicado 2020

Methylenetetrahydrofolate Reductase A1298C Polymorphism and Major Depressive Disorder

por Cho, Kevin, Amin, Zubair M, An, Jie, Rambaran, Kerry Anne, Johnson, Tyler B, Alzghari, Saeed K
Publicado 2017

Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified drinking water

por Johnson, Tyler B., Langin, Logan M., Zhao, Jing, Weimer, Jill M., Pearce, David A., Kovács, Attila D.
Publicado 2019

Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8(mnd) mice

por Holmes, Andrew D., White, Katherine A., Pratt, Melissa A., Johnson, Tyler B., Likhite, Shibi, Meyer, Kathrin, Weimer, Jill M.
Publicado 2022

Tracking sex-dependent differences in a mouse model of CLN6-Batten disease

por Poppens, McKayla J., Cain, Jacob T., Johnson, Tyler B., White, Katherine A., Davis, Samantha S., Laufmann, Rachel, Kloth, Alexander D., Weimer, Jill M.
Publicado 2019

Transmembrane Batten Disease Proteins Interact With a Shared Network of Vesicle Sorting Proteins, Impacting Their Synaptic Enrichment

por Rechtzigel, Mitchell J., Meyerink, Brandon L., Leppert, Hannah, Johnson, Tyler B., Cain, Jacob T., Ferrandino, Gavin, May, Danielle G., Roux, Kyle J., Brudvig, Jon J., Weimer, Jill M.
Publicado 2022

Glycerophosphoinositol is Elevated in Blood Samples From CLN3(Δex7-8) pigs, Cln3(Δex7-8) Mice, and CLN3-Affected Individuals

por Brudvig, Jon J, Swier, Vicki J, Johnson, Tyler B, Cain, Jacob C, Pratt, Melissa, Rechtzigel, Mitch, Leppert, Hannah, Dang Do, An N, Porter, Forbes D, Weimer, Jill M
Publicado 2022

Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1

por Johnson, Tyler B., Mechels, Keegan, Anderson, Ruth Ellen, Cain, Jacob T., Sturdevant, David A., Braddock, Stephen, Pinz, Hailey, Wilson, Mark A., Landsverk, Megan, Roux, Kyle J., Weimer, Jill M.
Publicado 2018

Author Correction: Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1

por Johnson, Tyler B., Mechels, Keegan, Anderson, Ruthellen H., Cain, Jacob T., Sturdevant, David A., Braddock, Stephen, Pinz, Hailey, Wilson, Mark A., Landsverk, Megan, Roux, Kyle J., Weimer, Jill M.
Publicado 2020

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes

por Swier, Vicki J., White, Katherine A., Johnson, Tyler B., Wang, Xiaojun, Han, Jimin, Pearce, David A., Singh, Ruchira, Drack, Arlene V., Pfeifer, Wanda, Rogers, Christopher S., Brudvig, Jon J., Weimer, Jill M.
Publicado 2023

Sortilin inhibition treats multiple neurodegenerative lysosomal storage disorders

por Leppert, Hannah G., Anderson, Joelle T., Timm, Kaylie J., Davoli, Cristina, Pratt, Melissa A., Booth, Clarissa D., White, Katherine A., Rechtzigel, Mitchell J., Meyerink, Brandon L., Johnson, Tyler B., Brudvig, Jon J., Weimer, Jill M.
Publicado 2023

Early postnatal administration of an AAV9 gene therapy is safe and efficacious in CLN3 disease

por Johnson, Tyler B., Brudvig, Jon J., Likhite, Shibi, Pratt, Melissa A., White, Katherine A., Cain, Jacob T., Booth, Clarissa D., Timm, Derek J., Davis, Samantha S., Meyerink, Brandon, Pineda, Ricardo, Dennys-Rivers, Cassandra, Kaspar, Brian K., Meyer, Kathrin, Weimer, Jill M.
Publicado 2023

Intracranial delivery of AAV9 gene therapy partially prevents retinal degeneration and visual deficits in CLN6-Batten disease mice

por White, Katherine A., Nelvagal, Hemanth R., Poole, Timothy A., Lu, Bin, Johnson, Tyler B., Davis, Samantha, Pratt, Melissa A., Brudvig, Jon, Assis, Ana B., Likhite, Shibi, Meyer, Kathrin, Kaspar, Brian K., Cooper, Jonathan D., Wang, Shaomei, Weimer, Jill M.
Publicado 2021

Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease

por Cain, Jacob T., Likhite, Shibi, White, Katherine A., Timm, Derek J., Davis, Samantha S., Johnson, Tyler B., Dennys-Rivers, Cassandra N., Rinaldi, Federica, Motti, Dario, Corcoran, Sarah, Morales, Pablo, Pierson, Christopher, Hughes, Stephanie M., Lee, Stella Y., Kaspar, Brian K., Meyer, Kathrin, Weimer, Jill M.
Publicado 2019

A human model of Batten disease shows role of CLN3 in phagocytosis at the photoreceptor–RPE interface

por Tang, Cynthia, Han, Jimin, Dalvi, Sonal, Manian, Kannan, Winschel, Lauren, Volland, Stefanie, Soto, Celia A., Galloway, Chad A., Spencer, Whitney, Roll, Michael, Milliner, Caroline, Bonilha, Vera L., Johnson, Tyler B., Latchney, Lisa, Weimer, Jill M., Augustine, Erika F., Mink, Jonathan W., Gullapalli, Vamsi K., Chung, Mina, Williams, David S., Singh, Ruchira
Publicado 2021