466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator

por Shrimali, Shivangi, Singh, Awantika, Manian, Rajeshkumar, Thakkar, Shraddha, Jones, Darin E., Aykin-Burns, Nukhet, Breen, Philip, Compadre, Cesar M.
Publicado 2023

Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects

por Shrum, Stephen A., Nukala, Ujwani, Shrimali, Shivangi, Pineda, Edith Nathalie, Krager, Kimberly J., Thakkar, Shraddha, Jones, Darin E., Pathak, Rupak, Breen, Philip J., Aykin-Burns, Nukhet, Compadre, Cesar M.
Publicado 2023

Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine

por Ordóñez, Paola E., Mery, David E., Sharma, Krishan K., Nemu, Saumyadip, Reynolds, William F., Enriquez, Raul G., Burns, Darcy C., Malagón, Omar, Jones, Darin E., Guzman, Monica L., Compadre, Cesar M.
Publicado 2020

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

por Moiani, Davide, Link, Todd M., Brosey, Chris A., Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E., Tsutakawa, Susan E., Tainer, John A.
Publicado 2021

GRB2 enforces homology-directed repair initiation by MRE11

por Ye, Zu, Xu, Shengfeng, Shi, Yin, Bacolla, Albino, Syed, Aleem, Moiani, Davide, Tsai, Chi-Lin, Shen, Qiang, Peng, Guang, Leonard, Paul G., Jones, Darin E., Wang, Bin, Tainer, John A., Ahmed, Zamal
Publicado 2021

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

por Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Publicado 2021

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

por Nguyen, My T., Moiani, Davide, Ahmed, Zamal, Arvai, Andrew S., Namjoshi, Sarita, Shin, Dave S., Fedorov, Yuriy, Selvik, Edward J., Jones, Darin E., Pink, John, Yan, Yan, Laverty, Daniel J., Nagel, Zachary D., Tainer, John A., Gerson, Stanton L.
Publicado 2021

Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds

por Mery, David E., Compadre, Amanda J., Ordóñez, Paola E., Selvik, Edward J., Morocho, Vladimir, Contreras, Jorge, Malagón, Omar, Jones, Darin E., Breen, Philip J., Balick, Michael J., Gaudio, Flavio G., Guzman, Monica L., Compadre, Cesar M.
Publicado 2022

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

por Syed, Aleem, Filandr, Frantisek, Patterson-Fortin, Jeffrey, Bacolla, Albino, Ravindranathan, Ramya, Zhou, Jia, McDonald, Drew T, Albuhluli, Mohammed E, Verway-Cohen, Amy, Newman, Joseph A, Tsai, Miaw-Sheue, Jones, Darin E, Schriemer, David C, D’Andrea, Alan D, Tainer, John A
Publicado 2023

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

por Houl, Jerry H., Ye, Zu, Brosey, Chris A., Balapiti-Modarage, Lakshitha P. F., Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L., Pourfarjam, Yasin, Warden, Leslie S., Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A., Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D., Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Publicado 2019