Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

por Jones, Deuan C, Alphey, Magnus S, Wyllie, Susan, Fairlamb, Alan H
Publicado 2012

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

por Nguyen, Suong, Jones, Deuan C., Wyllie, Susan, Fairlamb, Alan H., Phillips, Margaret A.
Publicado 2013

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi()

por Jones, Deuan C., Ariza, Antonio, Chow, Wing-Huen A., Oza, Sandra L., Fairlamb, Alan H.
Publicado 2010

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

por Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Publicado 2010

Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

por Walton, Jeffrey G A, Jones, Deuan C, Kiuru, Paula, Durie, Alastair J, Westwood, Nicholas J, Fairlamb, Alan H
Publicado 2011

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

por Richardson, John L, Nett, Isabelle R E, Jones, Deuan C, Abdille, Mohamed H, Gilbert, Ian H, Fairlamb, Alan H
Publicado 2009

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

por Jones, Deuan C., Foth, Bernardo J., Urbaniak, Michael D., Patterson, Stephen, Ong, Han B., Berriman, Matthew, Fairlamb, Alan H.
Publicado 2015

Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

por Perez-Pineiro, Rolando, Burgos, Asdrubal, Jones, Deuan C., Andrew, Lena C., Rodriguez, Hortensia, Suarez, Margarita, Fairlamb, Alan H., Wishart, David S.
Publicado 2009

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

por Patterson, Stephen, Jones, Deuan C, Shanks, Emma J, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H
Publicado 2009

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

por Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publicado 2011